公开(公告)号：US07645771B2

公开(公告)日：2010-01-12

申请号：US10538144

申请日：2003-12-12

Applicant: Wieslaw Mieczyslaw Kazmierski ,  Chrisopher Joseph Aquino ,  Neil Bifulco ,  Eric Eugene Boros ,  Brian Andrew Chauder ,  Pek Yoke Chong ,  Maosheng Duan ,  Felix Deanda, Jr. ,  Cecilia Suarez Koble ,  Ed Williams McLean ,  Jennifer Poole Peckham ,  Angilique C Perkins ,  James Benjamin Thompson ,  Dana Vanderwall

Inventor： Wieslaw Mieczyslaw Kazmierski ,  Chrisopher Joseph Aquino ,  Neil Bifulco ,  Eric Eugene Boros ,  Brian Andrew Chauder ,  Pek Yoke Chong ,  Maosheng Duan ,  Felix Deanda, Jr. ,  Cecilia Suarez Koble ,  Ed Williams McLean ,  Jennifer Poole Peckham ,  Angilique C Perkins ,  James Benjamin Thompson ,  Dana Vanderwall

IPC: A61K31/46

CPC classification number: C07D451/04

Abstract: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable derivatives thereof, useful in the treatment of prophylazis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replication, the prevention or treatment of HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的衍生物，其可用于治疗CCR5相关疾病和病症的预防，例如抑制HIV复制，预防或治疗HIV感染， 以及治疗所得的获得性免疫缺陷综合征（AIDS）。

公开(公告)号：US08222261B2

公开(公告)日：2012-07-17

申请号：US12373524

申请日：2009-01-13

Applicant: Subba R Katamreddy ,  Richard Dama Caldwell ,  Dennis Heyer ,  Vincente Samano ,  James Benjamin Thompson ,  Andrew J Carpenter ,  Christopher R Conlee ,  Eric Eugene Boros ,  Brian D Thompson

Inventor： Subba R Katamreddy ,  Richard Dama Caldwell ,  Dennis Heyer ,  Vincente Samano ,  James Benjamin Thompson ,  Andrew J Carpenter ,  Christopher R Conlee ,  Eric Eugene Boros ,  Brian D Thompson

IPC: A61K31/519

CPC classification number: C07D487/04 ,  A61K31/404 ,  A61K31/495 ,  A61K31/519 ,  C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14 ,  C07F9/65583

Abstract: The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly Type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.

Abstract translation: 本发明涉及可用于治疗代谢紊乱，特别是II型糖尿病和相关病症的新型化合物，以及制备和使用这些化合物的方法。