公开(公告)号：US20090149456A1

公开(公告)日：2009-06-11

申请号：US12095762

申请日：2006-12-04

Applicant: David Edward Uehling ,  Robert Dale Hubbard ,  Alex Gregory Waterson ,  Kimberly Petrov ,  Neil Bifulco, JR. ,  Joseph Wendell Wilson ,  Jennifer Gabriel Badiang ,  Mui Cheung ,  Mariko Yamabe

Inventor： David Edward Uehling ,  Robert Dale Hubbard ,  Alex Gregory Waterson ,  Kimberly Petrov ,  Neil Bifulco, JR. ,  Joseph Wendell Wilson ,  Jennifer Gabriel Badiang ,  Mui Cheung ,  Mariko Yamabe

IPC: A61K31/5377 ,  C07D239/24 ,  A61K31/506 ,  A61P35/00 ,  C07D413/14

CPC classification number: C07D471/04

Abstract: The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.

Abstract translation: 本发明提供2-嘧啶基吡唑并吡啶化合物，含有它们的组合物，以及制备方法及其作为药剂的用途。

公开(公告)号：US09434700B2

公开(公告)日：2016-09-06

申请号：US14521909

申请日：2014-10-23

Applicant: Neil Bifulco, Jr. ,  Lucian V. DiPietro ,  Brian L. Hodous ,  Chandrasekhar V. Miduturu

Inventor： Neil Bifulco, Jr. ,  Lucian V. DiPietro ,  Brian L. Hodous ,  Chandrasekhar V. Miduturu

IPC: C07D405/12 ,  A61K31/517 ,  C07D239/84 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D471/04 ,  C07D401/04 ,  C07D475/00 ,  C07D235/30 ,  C07D409/12 ,  C07D475/08

CPC classification number: C07D401/04 ,  C07D235/30 ,  C07D239/84 ,  C07D401/12 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D475/00

Abstract: Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Abstract translation: 本文描述的是FGFR-4的抑制剂，包括这些化合物的药物组合物，以及使用这些化合物和组合物的方法。

公开(公告)号：US09126951B2

公开(公告)日：2015-09-08

申请号：US14318149

申请日：2014-06-27

Applicant: Neil Bifulco, Jr. ,  Natasja Brooijmans ,  Brian L. Hodous ,  Joseph L. Kim ,  Chandrasekhar V. Miduturu

Inventor： Neil Bifulco, Jr. ,  Natasja Brooijmans ,  Brian L. Hodous ,  Joseph L. Kim ,  Chandrasekhar V. Miduturu

IPC: A61K31/4375 ,  C07D239/84 ,  C07D239/42 ,  C07D471/04 ,  C07D475/00 ,  C07D487/04 ,  A61K31/517 ,  A61K31/519

CPC classification number: C07K14/71 ,  A61K31/4375 ,  A61K31/517 ,  A61K31/519 ,  C07D239/42 ,  C07D239/84 ,  C07D295/155 ,  C07D401/04 ,  C07D471/04 ,  C07D475/00 ,  C07D475/04 ,  C07D487/04

Abstract: Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.

Abstract translation: 本文描述的是FGFR的抑制剂，包括这些化合物的药物组合物，以及使用这些化合物和组合物抑制酪氨酸激酶活性的方法。

公开(公告)号：US08569484B2

公开(公告)日：2013-10-29

申请号：US13322717

申请日：2010-05-28

Applicant: Neil Bifulco ,  Allison Laura Choy ,  Olga Quiroga ,  Brian Alan Sherer

Inventor： Neil Bifulco ,  Allison Laura Choy ,  Olga Quiroga ,  Brian Alan Sherer

IPC: C07D471/04 ,  C07F9/6561

CPC classification number: C07D471/04

Abstract: Compounds of formula (IA) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

Abstract translation: 描述了式（IA）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。

公开(公告)号：US20110190280A1

公开(公告)日：2011-08-04

申请号：US12674016

申请日：2008-08-27

Applicant: George Adjabeng ,  Neil Bifulco ,  Ronda G. Davis-Ward ,  Scott Howard Dickerson ,  Kelly Horne Donaldson ,  Philip Anthony Harris ,  Keith Hornberger ,  Kimberly Petrov ,  Tara Renae Rheault ,  Gregory Schaaf ,  John Stellwagen ,  David Edward Uehling ,  Alex Gregory Waterson

Inventor： George Adjabeng ,  Neil Bifulco ,  Ronda G. Davis-Ward ,  Scott Howard Dickerson ,  Kelly Horne Donaldson ,  Philip Anthony Harris ,  Keith Hornberger ,  Kimberly Petrov ,  Tara Renae Rheault ,  Gregory Schaaf ,  John Stellwagen ,  David Edward Uehling ,  Alex Gregory Waterson

IPC: A61K31/541 ,  C07D403/14 ,  A61K31/506 ,  C07D413/14 ,  A61K31/5377 ,  C07D417/14 ,  C07D498/04 ,  A61K31/5365 ,  A61P35/00

CPC classification number: C07D417/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

Abstract: The present invention provides thiazole and oxazole compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Abstract translation: 本发明提供噻唑和恶唑化合物，含有它们的组合物，以及制备方法及其用作药剂的方法。

公开(公告)号：US20060229336A1

公开(公告)日：2006-10-12

申请号：US10538144

申请日：2003-12-12

Applicant: Wieslaw Kazmierski ,  Chrisopher Aquino ,  Neil Bifulco ,  Eric Boros ,  Brian Chauder ,  Pek Chong ,  Maosheng Duan ,  Felix Deanda ,  Cecilia Koble ,  Ed Mclean ,  Jennifer Peckham ,  Angilique Perkins ,  James Thompson ,  Dana Vanderwall

Inventor： Wieslaw Kazmierski ,  Chrisopher Aquino ,  Neil Bifulco ,  Eric Boros ,  Brian Chauder ,  Pek Chong ,  Maosheng Duan ,  Felix Deanda ,  Cecilia Koble ,  Ed Mclean ,  Jennifer Peckham ,  Angilique Perkins ,  James Thompson ,  Dana Vanderwall

IPC: A61K31/454 ,  C07D403/02 ,  C07D211/32

CPC classification number: C07D451/04

Abstract: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable derivatives thereof, useful in the treatment of prophylazis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replication, the prevention or treatment of HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).

Abstract translation: 本发明涉及式（I）化合物或其药学上可接受的衍生物，其可用于治疗CCR5相关疾病和病症的预防，例如抑制HIV复制，预防或治疗HIV感染， 以及治疗所得的获得性免疫缺陷综合征（AIDS）。

公开(公告)号：US20150197519A1

公开(公告)日：2015-07-16

申请号：US14596987

申请日：2015-01-14

Applicant: Neil Bifulco, JR. ,  Lucian V. DiPietro ,  Chandrasekhar V. Miduturu

Inventor： Neil Bifulco, JR. ,  Lucian V. DiPietro ,  Chandrasekhar V. Miduturu

IPC: C07D471/04 ,  C07D217/16 ,  C07D403/04 ,  C07D413/04 ,  C07D239/74

CPC classification number: C07D471/04 ,  A61K31/517 ,  C07D217/14 ,  C07D217/16 ,  C07D239/74 ,  C07D403/04 ,  C07D413/04 ,  C07D487/04 ,  C07D487/14

Abstract: Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of FGFR-4.

Abstract translation: 本文描述了FGFR-4的抑制剂，包括这些化合物的药物组合物，以及使用这些化合物和组合物抑制FGFR-4活性的方法。

公开(公告)号：US20140088100A1

公开(公告)日：2014-03-27

申请号：US13939967

申请日：2013-07-11

Applicant: Neil Bifulco, JR. ,  Natasja Brooijmans ,  Brian L. Hodous ,  Joseph L. Kim ,  Chandrasekhar V. Miduturu

Inventor： Neil Bifulco, JR. ,  Natasja Brooijmans ,  Brian L. Hodous ,  Joseph L. Kim ,  Chandrasekhar V. Miduturu

IPC: C07D487/04 ,  C07D295/155 ,  C07D475/00 ,  C07D239/84 ,  C07D471/04

CPC classification number: C07K14/71 ,  A61K31/4375 ,  A61K31/517 ,  A61K31/519 ,  C07D239/42 ,  C07D239/84 ,  C07D295/155 ,  C07D401/04 ,  C07D471/04 ,  C07D475/00 ,  C07D475/04 ,  C07D487/04

Abstract: Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases.

Abstract translation: 本文描述的是FGFR的抑制剂，包括这些化合物的药物组合物，以及使用这些化合物和组合物抑制酪氨酸激酶活性的方法。

公开(公告)号：US20120122817A1

公开(公告)日：2012-05-17

申请号：US13322717

申请日：2010-05-28

Applicant: Neil Bifulco ,  Allison Laura Choy ,  Olga Quiroga ,  Brian Alan Sherer

Inventor： Neil Bifulco ,  Allison Laura Choy ,  Olga Quiroga ,  Brian Alan Sherer

IPC: A61K31/4545 ,  C07F9/6561 ,  A61K31/675 ,  A61K31/5377 ,  A61P13/02 ,  A61K31/541 ,  A61P31/04 ,  A61P17/00 ,  A61P11/08 ,  A61P11/02 ,  C07D471/04 ,  A61K31/496

CPC classification number: C07D471/04

Abstract: Compounds of formula (IA) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their use in the treatment of bacterial infections are also described.

Abstract translation: 描述了式（IA）化合物及其药学上可接受的盐。 还描述了其制备方法，含有它们的药物组合物，其作为药物的用途及其在治疗细菌感染中的用途。

公开(公告)号：US20110319392A1

公开(公告)日：2011-12-29

申请号：US13254463

申请日：2010-03-10

Applicant: George Adjabeng ,  Erich Baum ,  Neil Bifulco, JR. ,  Ronda G. Davis-Ward ,  Scott Howard Dickerson ,  Kelly Horne Donaldson ,  Keith Hornberger ,  Kimberly Petrov ,  Tara Renae Reheault ,  Douglas McCord Sammond ,  Gregory M. Schaaf

Inventor： George Adjabeng ,  Erich Baum ,  Neil Bifulco, JR. ,  Ronda G. Davis-Ward ,  Scott Howard Dickerson ,  Kelly Horne Donaldson ,  Keith Hornberger ,  Kimberly Petrov ,  Tara Renae Reheault ,  Douglas McCord Sammond ,  Gregory M. Schaaf

IPC: A61K31/506 ,  C07D419/04 ,  C07D413/14 ,  A61P35/00 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/551 ,  C07D417/14 ,  C07D498/04

CPC classification number: C07D417/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04

Abstract: The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Abstract translation: 本发明提供噻唑磺酰胺和恶唑磺酰胺化合物，含有它们的组合物，以及其制备方法和用作药剂的方法。