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公开(公告)号：US07645771B2
公开(公告)日：2010-01-12
申请号：US10538144
申请日：2003-12-12
申请人： Wieslaw Mieczyslaw Kazmierski , Chrisopher Joseph Aquino , Neil Bifulco , Eric Eugene Boros , Brian Andrew Chauder , Pek Yoke Chong , Maosheng Duan , Felix Deanda, Jr. , Cecilia Suarez Koble , Ed Williams McLean , Jennifer Poole Peckham , Angilique C Perkins , James Benjamin Thompson , Dana Vanderwall
发明人： Wieslaw Mieczyslaw Kazmierski , Chrisopher Joseph Aquino , Neil Bifulco , Eric Eugene Boros , Brian Andrew Chauder , Pek Yoke Chong , Maosheng Duan , Felix Deanda, Jr. , Cecilia Suarez Koble , Ed Williams McLean , Jennifer Poole Peckham , Angilique C Perkins , James Benjamin Thompson , Dana Vanderwall
IPC分类号： A61K31/46
CPC分类号： C07D451/04
摘要： The present invention relates to compounds of formula (I) or a pharmaceutically acceptable derivatives thereof, useful in the treatment of prophylazis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replication, the prevention or treatment of HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的衍生物，其可用于治疗CCR5相关疾病和病症的预防，例如抑制HIV复制，预防或治疗HIV感染， 以及治疗所得的获得性免疫缺陷综合征（AIDS）。
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公开(公告)号：US20060229336A1
公开(公告)日：2006-10-12
申请号：US10538144
申请日：2003-12-12
申请人： Wieslaw Kazmierski , Chrisopher Aquino , Neil Bifulco , Eric Boros , Brian Chauder , Pek Chong , Maosheng Duan , Felix Deanda , Cecilia Koble , Ed Mclean , Jennifer Peckham , Angilique Perkins , James Thompson , Dana Vanderwall
发明人： Wieslaw Kazmierski , Chrisopher Aquino , Neil Bifulco , Eric Boros , Brian Chauder , Pek Chong , Maosheng Duan , Felix Deanda , Cecilia Koble , Ed Mclean , Jennifer Peckham , Angilique Perkins , James Thompson , Dana Vanderwall
IPC分类号： A61K31/454 , C07D403/02 , C07D211/32
CPC分类号： C07D451/04
摘要： The present invention relates to compounds of formula (I) or a pharmaceutically acceptable derivatives thereof, useful in the treatment of prophylazis of CCR5-related diseases and disorders, for example, in the inhibition of HIV replication, the prevention or treatment of HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的衍生物，其可用于治疗CCR5相关疾病和病症的预防，例如抑制HIV复制，预防或治疗HIV感染， 以及治疗所得的获得性免疫缺陷综合征（AIDS）。
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公开(公告)号：US20110152237A1
公开(公告)日：2011-06-23
申请号：US12936545
申请日：2010-08-26
申请人： Pingyun Chen , Ricky Couch , Maosheng Duan , Richard Martin Grimes , Wieslaw Mieczyslaw Kazmierski , Beth Adams Norton , Matthew Tallant , Pingyun Chen , Ricky Couch , Maosheng Duan , Richard Martin Grimes , Wleslaw Mieczyslaw Kazmierski , Beth Adams Norton , Matthew Tallant
发明人： Pingyun Chen , Ricky Couch , Maosheng Duan , Richard Martin Grimes , Wieslaw Mieczyslaw Kazmierski , Beth Adams Norton , Matthew Tallant , Pingyun Chen , Ricky Couch , Maosheng Duan , Richard Martin Grimes , Wleslaw Mieczyslaw Kazmierski , Beth Adams Norton , Matthew Tallant
IPC分类号： A61K31/4178 , C07D491/113 , C07D495/10 , C07D491/107 , C07D403/14 , C07D471/10 , C07D487/10 , A61K31/438 , A61P31/12 , A61P31/14
CPC分类号： A61K31/4178 , A61K31/435 , A61K31/7056 , A61K38/21 , C07D403/12 , C07D403/14 , C07D471/10 , C07D487/10 , C07D487/20 , C07D491/10 , C07D491/107 , C07D491/113 , C07D495/10 , C07D519/00
摘要： Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts.
摘要翻译： 公开了式III的化合物。 还公开了化合物的盐，包含化合物或盐的药物组合物，以及通过施用化合物或盐治疗HCV感染的方法。
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公开(公告)号：US08592395B2
公开(公告)日：2013-11-26
申请号：US13386731
申请日：2010-07-23
IPC分类号： C07D451/04 , C07D471/04 , A61K31/46 , A61K31/5377 , A61K31/675 , A61P1/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/18 , A61P31/20 , A61P35/00 , A61P37/06 , A61P37/08 , C07F9/6561
CPC分类号： C07D451/04
摘要： The present invention relates to compounds of Formula (I) and (Ia) useful in the treatment of CCR5-related diseases and disorders, for example, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).
摘要翻译： 本发明涉及可用于治疗CCR5相关疾病和病症的式（I）和（Ia）化合物，例如预防或治疗HIV感染，以及治疗所得的获得性免疫缺陷综合征 （艾滋病）。
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公开(公告)号：US20120295877A1
公开(公告)日：2012-11-22
申请号：US13386731
申请日：2010-07-23
IPC分类号： C07D451/04 , C07F9/6561 , A61K31/675 , C07D471/04 , A61K31/5377 , A61P31/18 , A61P25/00 , A61P29/00 , A61P3/10 , A61P37/06 , A61P11/06 , A61P1/00 , A61P13/12 , A61P25/28 , A61P7/02 , A61P37/08 , A61P9/10 , A61P17/00 , A61P19/04 , A61P35/00 , A61P31/20 , A61P17/02 , A61K31/46
CPC分类号： C07D451/04
摘要： The present invention relates to compounds of Formula (I) and (Ia) useful in the treatment of CCR5-related diseases and disorders, for example, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).
摘要翻译： 本发明涉及可用于治疗CCR5相关疾病和病症的式（I）和（Ia）化合物，例如预防或治疗HIV感染，以及治疗所得的获得性免疫缺陷综合征 （艾滋病）。
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公开(公告)号：US07589207B2
公开(公告)日：2009-09-15
申请号：US10538135
申请日：2003-12-12
IPC分类号： C07D451/00 , A01N43/42
CPC分类号： C07C271/24 , C07C2601/14 , C07D207/12 , C07D211/26 , C07D211/28 , C07D211/34 , C07D211/58 , C07D211/66 , C07D235/08 , C07D261/20 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04 , C07D451/04 , C07D471/10
摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).
摘要翻译： 本发明涉及可用于治疗CCR5相关疾病和病症的式（I）化合物或其药学上可接受的衍生物，例如可用于抑制HIV复制，预防或治疗HIV感染， 以及治疗所得的获得性免疫缺陷综合征（AIDS）。
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公开(公告)号：US07452992B2
公开(公告)日：2008-11-18
申请号：US10538145
申请日：2003-12-12
IPC分类号： C07D413/00 , C07D225/00 , C07D265/30
CPC分类号： C07D451/04 , C07D413/06 , C07D413/14 , C07D417/14 , C07D471/10
摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in the inhibition of HIV replication, the prevention or treatment of an HIV infection, and in the treatment of the resulting acquired immune deficiency syndrome (AIDS).
摘要翻译： 本发明涉及可用于治疗CCR5相关疾病和病症的式（I）化合物或其药学上可接受的衍生物，例如可用于抑制HIV复制，预防或治疗HIV感染， 以及治疗所得的获得性免疫缺陷综合征（AIDS）。
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8.发明申请PROCESSES AND INTERMEDIATES FOR CARBAMOYLPYRIDONE HIV INTEGRASE INHIBITORS 有权卡巴酰亚胺艾滋病毒整合酶抑制剂的方法和中间体公开(公告)号：US20110263855A1
公开(公告)日：2011-10-27
申请号：US13128457
申请日：2009-12-09
IPC分类号： C07D498/14 , C07D211/86
CPC分类号： C07D213/82 , C07D213/79 , C07D213/803 , C07D213/807 , C07D498/14
摘要： Processes are provided which create an aldehyde methylene, or hydrated or hemiacetal methylene attached to a heteroatom of a 6 membered ring without going through an olefinic group and without the necessity of using an osmium reagent. In particular, a compound of formula (I) can be produced from (II) and avoid the use of an allyl amine: (formulae I and II) where R, P1P3, R3 and Rx are as described herein.
摘要翻译： 提供了产生醛亚甲基或连接到6元环的杂原子的水合或半缩醛亚甲基而不经过烯属基团而不需要使用锇试剂的方法。 特别地，式（I）化合物可以由（II）制备，并避免使用烯丙基胺：（式I和II）其中R，P1P3，R3和Rx如本文所述。
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9.发明授权Processes and intermediates for carbamoylpyridone HIV integrase inhibitors 有权氨基甲酰吡啶酮HIV整合酶抑制剂的方法和中间体公开(公告)号：US08552187B2
公开(公告)日：2013-10-08
申请号：US13128457
申请日：2009-12-09
IPC分类号： C07D213/79 , C07D213/803 , C07D498/14 , C07D211/86
CPC分类号： C07D213/82 , C07D213/79 , C07D213/803 , C07D213/807 , C07D498/14
摘要： Processes are provided which create an aldehyde methylene, or hydrated or hemiacetal methylene attached to a heteroatom of a 6 membered ring without going through an olefinic group and without the necessity of using an osmium reagent. In particular, a compound of formula (I) can be produced from (II) and avoid the use of an allyl amine: (formulae I and II) where R, P1 P3, R3 and Rx are as described herein.
摘要翻译： 提供了产生醛亚甲基或连接到6元环的杂原子的水合或半缩醛亚甲基而不经过烯属基团而不需要使用锇试剂的方法。 特别地，式（I）化合物可以由（II）制备，并避免使用烯丙基胺：（式I和II）其中R，P1 P3，R3和Rx如本文所述。
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公开(公告)号：US08344155B2
公开(公告)日：2013-01-01
申请号：US12936545
申请日：2010-08-26
申请人： Pingyun Chen , Ricky Couch , Maosheng Duan , Beth Adams Norton
发明人： Pingyun Chen , Ricky Couch , Maosheng Duan , Beth Adams Norton
IPC分类号： A61K31/4184 , C07D235/02
CPC分类号： A61K31/4178 , A61K31/435 , A61K31/7056 , A61K38/21 , C07D403/12 , C07D403/14 , C07D471/10 , C07D487/10 , C07D487/20 , C07D491/10 , C07D491/107 , C07D491/113 , C07D495/10 , C07D519/00
摘要： Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts.
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