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27 条记录 (耗时 0.031 秒)

    6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling
    1.
    发明授权
    6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling 有权
    6-O-取代的苯并恶唑和苯并噻唑化合物以及抑制CSF-1R信号传导的方法

    公开(公告)号：US08173689B2

    公开(公告)日：2012-05-08

    申请号：US12387946

    申请日：2009-05-08

    申请人： James C. Sutton ,  Marion Wiesmann

    发明人： James C. Sutton ,  Marion Wiesmann

    IPC分类号： A61K31/423 ,  A61K31/444 ,  A61K31/428 ,  A61K31/506 ,  A61P19/10

    CPC分类号： C07D413/12 ,  C07D417/12

    摘要： Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

    摘要翻译： 公开了苯并恶唑和苯并噻唑化合物及其立体异构体，互变异构体，溶剂合物，氧化物，酯和前药及其药学上可接受的盐。 还公开了单独或与至少一种另外的治疗剂组合的化合物与药学上可接受的载体的组合，以及化合物单独或与至少一种另外的治疗剂组合的用途。 这些实施方案可用于抑制细胞增殖，抑制肿瘤的生长和/或复分解，治疗或预防癌症，治疗或预防退行性骨疾病如类风湿性关节炎和/或抑制分子如CSF-1R。

    Sulfonylpyrrolidine modulators of androgen receptor function and method
    2.
    发明授权
    Sulfonylpyrrolidine modulators of androgen receptor function and method 有权
    磺酰吡咯烷酮调节剂的雄激素受体功能及方法

    公开(公告)号：US07989640B2

    公开(公告)日：2011-08-02

    申请号：US12880692

    申请日：2010-09-13

    申请人： Lawrence G. Hamann ,  Yingzhi Bi ,  Mark C. Manfredi ,  Alexandra A. Nirschl ,  James C. Sutton

    发明人： Lawrence G. Hamann ,  Yingzhi Bi ,  Mark C. Manfredi ,  Alexandra A. Nirschl ,  James C. Sutton

    IPC分类号： C07D207/00

    CPC分类号： C07D285/14 ,  C07D207/48

    摘要： Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure wherein R1, R2 and R4, are as defined herein; G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted; n is an integer of 1 or 2; m is an integer of 1 or 2; Z is oxygen (—O—) or NR4h; a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.

    摘要翻译： 提供了可用于治疗雄激素受体相关病症例如年龄相关疾病的化合物，该化合物具有其中R1，R2和R4如本文所定义的结构; G是芳基，杂环或杂芳基，其中所述基团是单环或多环，并且其任选被取代; n为1或2的整数; m为1或2的整数; Z是氧（-O-）或NR4h; 前药酯，其所有立体异构体和其药学上可接受的盐。 还提供了治疗雄激素受体相关病症如年龄相关疾病的方法。

    Dynamic rotating ballistic shield
    6.
    发明授权
    Dynamic rotating ballistic shield 失效
    动态旋转防弹盾

    公开(公告)号：US5375505A

    公开(公告)日：1994-12-27

    申请号：US22234

    申请日：1993-02-25

    申请人： James C. Sutton

    发明人： James C. Sutton

    IPC分类号： F41H5/18

    CPC分类号： F41H5/18 ,  F41H5/26

    摘要： A dynamic rotating ballistic shield for protecting an enclosed viewing dee. A rotating inner armor sleeve around the device includes a sleeve opening. When the sleeve aligned with a cap opening of an outer armor cap which concentrically surrounds the rotatable inner armor sleeve, a substantially unobstructed field-of-view for the objective window is obtained, with substantial ballistic shield protection.

    摘要翻译： 一种用于保护封闭式观察装置的动态旋转防弹盾构。 围绕装置的旋转内装套筒包括套筒开口。 当套筒与同心地围绕可旋转的内装甲套筒的外装甲帽的盖开口对齐时，获得了用于客观窗的基本无阻碍的视场，具有实质的防弹保护。

    SULFONYLPYRROLIDINE MODULATORS OF ANDROGEN RECEPTOR FUNCTION AND METHOD
    7.
    发明申请
    SULFONYLPYRROLIDINE MODULATORS OF ANDROGEN RECEPTOR FUNCTION AND METHOD 有权
    雄激素受体功能和方法的磺酰胆碱调节剂

    公开(公告)号：US20110015408A1

    公开(公告)日：2011-01-20

    申请号：US12880692

    申请日：2010-09-13

    申请人： Lawrence G. Hamann ,  Yingzhi Bi ,  Mark C. Manfredi ,  Alexandra A. Nirschl ,  James C. Sutton

    发明人： Lawrence G. Hamann ,  Yingzhi Bi ,  Mark C. Manfredi ,  Alexandra A. Nirschl ,  James C. Sutton

    IPC分类号： C07D207/48

    CPC分类号： C07D285/14 ,  C07D207/48

    摘要： Compounds are provided which are useful in the treatment of androgen receptor-associated conditions, such as age-related diseases, which compounds have the structure whereinR1, R2 and R4, are as defined herein;G is an aryl, heterocyclo or heteroaryl group, wherein said group is mono- or polycyclic, and which is optionally substituted;n is an integer of 1 or 2;m is an integer of 1 or 2;Z is oxygen (—O—) or NR4h;a prodrug ester, all stereoisomers thereof and a pharmaceutically acceptable salt thereof. A method for treating androgen receptor-associated conditions such as age-related diseases is also provided.

    摘要翻译： 提供了可用于治疗雄激素受体相关病症例如年龄相关疾病的化合物，该化合物具有其中R1，R2和R4如本文所定义的结构; G是芳基，杂环或杂芳基，其中所述基团是单环或多环，并且其任选被取代; n为1或2的整数; m为1或2的整数; Z是氧（-O-）或NR4h; 前药酯，其所有立体异构体和其药学上可接受的盐。 还提供了治疗雄激素受体相关病症如年龄相关疾病的方法。

    Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
    10.
    发明授权
    Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions 有权
    P2Y1受体的碳环和杂环拮抗剂可用于治疗血栓形成

    公开(公告)号：US07714002B2

    公开(公告)日：2010-05-11

    申请号：US11474841

    申请日：2006-06-26

    申请人： James C. Sutton

    发明人： James C. Sutton

    IPC分类号： A61K31/44 ,  C07D213/69 ,  C07D213/74

    CPC分类号： C07D213/74 ,  C07D213/69

    摘要： The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R6 are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.

    摘要翻译： 本发明提供新的尿素模拟物和式（I）的类似物：或其立体异构体，互变异构体，药学上可接受的盐或溶剂化物形式，其中变量A，B，W和R6如本文所定义。 这些化合物是可用作药物的人P2Y1受体的选择性抑制剂。