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41 条记录 (耗时 0.024 秒)

    Self adjustable exit port
    1.
    发明授权
    Self adjustable exit port 失效
    自调节出口

    公开(公告)号：US05997527A

    公开(公告)日：1999-12-07

    申请号：US45944

    申请日：1998-03-23

    申请人： Juan C. Gumucio ,  Keith E. Dionne ,  James E. Brown

    发明人： Juan C. Gumucio ,  Keith E. Dionne ,  James E. Brown

    IPC分类号： A61K9/48 ,  A61K9/00 ,  A61K9/22 ,  A61K9/52

    CPC分类号： A61K9/0004

    摘要： A delivery device having a first chamber containing an osmotic agent, a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communication with the second chamber is an orifice which comprises a slit valve. In the presence of pressure, the beneficial agent pushes through the slit, opening up a channel for delivery of the beneficial agent and creating flow. Because the slit remains closed in the absence of flow (or when the pressure is below the pressure required to open the slit), back diffusion of external fluids is eliminated when the slit is closed, which prevents contamination of the beneficial agent in the second chamber by external fluids. In addition, forward diffusion of the beneficial agent out of the capsule is prevented when the slit is closed. The slit valve opens only to the minimum dimension required to allow the flow generated by the osmotic pumping rate. The slit valve also allows a flow path to open around any obstruction in the slit valve to prevent clogging.

    摘要翻译： 一种输送装置，具有含有渗透剂的第一室，形成第一室的壁的膜，通过渗透吸入流体的第一室;含有要输送的有益剂的第二室和分离两个室的活动活塞。 与第二腔室流体连通的是包括狭缝阀的孔口。 在存在压力的情况下，有益剂推动狭缝，打开用于输送有益剂并产生流动的通道。 因为缝隙在没有流动的情况下保持关闭（或当压力低于打开狭缝所需的压力时），当狭缝闭合时，外部流体的反向扩散被消除，这防止有益剂在第二腔室中的污染 通过外部流体。 此外，当狭缝闭合时，防止有益剂从胶囊中向前扩散。 狭缝阀仅打开允许由渗透泵送速率产生的流量所需的最小尺寸。 狭缝阀还允许流动通道围绕狭缝阀中的任何阻塞开放以防止堵塞。

    Self adjustable exit port
    2.
    发明授权
    Self adjustable exit port 有权
    自调节出口

    公开(公告)号：US06217906B1

    公开(公告)日：2001-04-17

    申请号：US09397507

    申请日：1999-09-17

    申请人： Juan C. Gumucio ,  Keith E. Dionne ,  James E. Brown

    发明人： Juan C. Gumucio ,  Keith E. Dionne ,  James E. Brown

    IPC分类号： A23K118

    CPC分类号： A61K9/0004

    摘要： A delivery device having a first chamber containing an osmotic agent, a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communication with the second chamber is an orifice which comprises a slit valve. In the presence of pressure, the beneficial agent pushes through the slit, opening up a channel for delivery of the beneficial agent and creating flow. Because the slit remains closed in the absence of flow (or when the pressure is below the pressure required to open the slit), back diffusion of external fluids is eliminated when the slit is closed, which prevents contamination of the beneficial agent in the second chamber by external fluids. In addition, forward diffusion of the beneficial agent out of the capsule is prevented when the slit is closed. The slit valve opens only to the minimum dimension required to allow the flow generated by the osmotic pumping rate. The slit valve also allows a flow path to open around any obstruction in the slit valve to prevent clogging.

    摘要翻译： 一种输送装置，具有含有渗透剂的第一室，形成第一室的壁的膜，通过渗透吸入流体的第一室;含有要输送的有益剂的第二室和分离两个室的活动活塞。 与第二腔室流体连通的是包括狭缝阀的孔口。 在存在压力的情况下，有益剂推动狭缝，打开用于输送有益剂并产生流动的通道。 因为缝隙在没有流动的情况下保持关闭（或当压力低于打开狭缝所需的压力时），当狭缝闭合时，外部流体的反向扩散被消除，这防止有益剂在第二腔室中的污染 通过外部流体。 此外，当狭缝闭合时，防止有益剂从胶囊中向前扩散。 狭缝阀仅打开允许由渗透泵送速率产生的流量所需的最小尺寸。 狭缝阀还允许流动通道围绕狭缝阀中的任何阻塞开放以防止堵塞。