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    Interferon induction in animals by amines
    2.
    发明授权
    Interferon induction in animals by amines 失效
    通过胺对动物进行干扰素诱导

    公开(公告)号：US4491583A

    公开(公告)日：1985-01-01

    申请号：US514670

    申请日：1983-07-18

    申请人： Timothy H. Cronin ,  Hermann Faubl ,  William W. Hoffman ,  James J. Korst

    发明人： Timothy H. Cronin ,  Hermann Faubl ,  William W. Hoffman ,  James J. Korst

    IPC分类号： A61K31/495 ,  C07C229/38 ,  C07C291/04 ,  C07D317/58 ,  C07D241/04

    CPC分类号： C07C255/00 ,  C07C229/38 ,  C07C291/04 ,  C07D317/58 ,  Y10S514/889

    摘要： A process for inducing the production of endogenous interferon in a vertebrate animal which comprises parenterally, intranasally or topically adminstering to the animal an interferon-inducing effective amount of composition containing as the essential active ingredient a compound of the formula ##STR1## or a non-toxic acid addition salt thereof wherein R.sub.7 and R.sub.8 are each alkyl of from 12 to 30 carbon atoms and Z is selected from the group consisting of N-(lower alkyl)-piperazino and N-(W-hydroxy-lower alkyl)-piperazino, said lower alkyl groups having from 1 to 4 carbon atoms.

    摘要翻译： 一种在脊椎动物中诱导产生内源性干扰素的方法，其包括肠胃外，鼻内或局部施用给动物干扰素诱导的有效量的组合物，其含有作为必需活性成分的式IMA化合物或非 - 其中R 7和R 8各自为12至30个碳原子的烷基，Z选自N-（低级烷基） - 哌嗪基和N-（W-羟基 - 低级烷基） - 哌嗪基， 所述低级烷基具有1至4个碳原子。

    Interferon induction in animals by amines
    4.
    发明授权
    Interferon induction in animals by amines 失效

    公开(公告)号：US4087552A

    公开(公告)日：1978-05-02

    申请号：US687514

    申请日：1976-05-18

    申请人： Timothy H. Cronin ,  Hermann Faubl ,  William W. Hoffman ,  James J. Korst

    发明人： Timothy H. Cronin ,  Hermann Faubl ,  William W. Hoffman ,  James J. Korst

    IPC分类号： C07C275/14 ,  A61K31/135 ,  A61K31/205 ,  A61K31/495

    CPC分类号： C07C275/14

    摘要： Combating viral infections in vertebrate animals by administering to the animals an amine selected from those having the formulae: ##STR1## and the non-toxic acid addition salts thereof wherein R.sub.1 is selected from the group consisting of alkyl of from 1 to 20 carbon atoms, aralkyl, aryloxyalkyl, hydroxyalkyl of from 2 to 8 carbon atoms and ##STR2## R.sub.2 is selected from the group consisting of alkyl of from 12 to 20 carbon atoms, aralkyl and aryloxyalkyl of from 12 to 24 carbon atoms and ##STR3## R.sup.o is alkoxy of from 1 to 18 carbon atoms; EACH OF R' and R" is selected from the group consisting of hydrogen, alkyl, alkoxy of from 1 to 18 carbon atoms; R' and R" when taken together are methylenedioxy;Provided that the total number of carbon atoms in R.sup.o, R' and R" is from 5 to 48;R.sub.3 is selected from the group consisting of hydrogen, alkyl of from 1 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, phenylcarbamoyloxy(lower alkyl), .omega.-carboxyalkanoyloxy(lower alkyl), allyl, alkanoyl of from 1 to 6 carbon atoms, alkanoyloxy(lower alkyl), carbo(lower alkoxy)lower alkyl, carboxy(lower alkyl), alkoxy(lower alkyl) and gem-di(lower alkoxy)lower alkyl;R.sub.4 is selected from the group consisting of hydrogen, alkyl of from 1 to 8 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, carbo(lower alkoxy)lower alkyl, alkanoyloxy(lower alkyl), carboxy(lower alkyl), alkoxy(lower alkyl), phenyl-carbamoyloxy(lower alkyl), .omega.-carboxyalkanoyloxy(lower alkyl), allyl, dihydroxyalkyl of from 3 to 8 carbon atoms, and morpholinoethyl; with the proviso that no more than two of the R variables are hydroxyalkyl;R.sub.3 and R.sub.4 when taken together with the nitrogen to which they are attached are morpholino;X is selected from the group consisting of straight chain alkylene of from 2 to 6 carbon atoms and ##STR4## X' is selected from the group consisting of X, phenylenedimethylene and ##STR5## m is 0 or 1, with the provisos that only one of X and X'is ##STR6## and when X' is phenylenedimethylene, m is 0; Y is selected from the group consisting of straight chain alkylene of from 2 to 8 carbon atoms and phenylenedimethylene;A is selected from the group consisting of hydrogen, cyano, hydroxy, alkoxy of from 1 to 20 carbon atoms, alkanoyloxy of from 2 to 20 carbon atoms, phenylcarbamoyloxy, chloro, bromo, .omega.-carboxyalkanoyloxy(lower alkyl), alkanoyloxy of from 1 to 6 carbon atoms, carbo(lower alkoxy) and alkanoylthio of from 2 to 20 carbon atoms and alkylthio of from 1 to 20 carbon atoms;R.sub.5 is selected from the group consisting of hydrogen, alkyl of from 1 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, (lower alkoxy)lower alkyl and ##STR7## R.sub.6 is selected from the group consisting of hydrogen, alkyl of from 12 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, (lower alkoxy)lower alkyl and ##STR8## R.sub.7 is selected from the group consisting of alkyl of from 12 to 20 carbon atoms and ##STR9## R.sub.8 is selected from the group consisting of alkyl of from 1 to 20 carbon atoms and ##STR10## each of p and n is 0 or an integer from 1 to 6, with the proviso that the sum of p and n is no greater than 6; andZ is selected from the group consisting of .omega.-carboxy(lower alkyl), morpholino, piperidino, piperazino, N-(.omega.-hydroxy lower alkyl)piperazino and N-(lower alkyl)piperazino.