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公开(公告)号：US4034040A
公开(公告)日：1977-07-05
申请号：US558224
申请日：1975-03-14
IPC分类号： C07C229/38 , C07C275/14 , C07C291/04 , C07D317/58 , C07C87/28
CPC分类号： C07C229/38 , C07C275/14 , C07C291/04 , C07D317/58
摘要： Compounds of the formula ##STR1## or a non-toxic acid addition salt thereof wherein R.sub.1 is alkyl of from 1 to 20 carbon atoms;R.sub.2 is alkyl of from 12 to 20 carbon atoms;R.sub.3 is selected from the group consisting of hydrogen and hydroxyalkyl of from 2 to 8 carbon atoms; andR.sub.4 is selected from the group consisting of hydrogen, alkyl of from 1 to 8 carbon atoms and hydroxyalkyl of from 2 to 8 carbon atoms, said compounds are useful for combating viral infections in vertebrate animals.
摘要翻译： 式（I）的化合物或其无毒的酸加成盐，其中R 1为1至20个碳原子的烷基; R2是12-20个碳原子的烷基; R3选自氢和2-8个碳原子的羟基烷基; 并且R 4选自氢，1至8个碳原子的烷基和2至8个碳原子的羟烷基，所述化合物可用于对抗脊椎动物中的病毒感染。
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公开(公告)号：US4491583A
公开(公告)日：1985-01-01
申请号：US514670
申请日：1983-07-18
IPC分类号： A61K31/495 , C07C229/38 , C07C291/04 , C07D317/58 , C07D241/04
CPC分类号： C07C255/00 , C07C229/38 , C07C291/04 , C07D317/58 , Y10S514/889
摘要： A process for inducing the production of endogenous interferon in a vertebrate animal which comprises parenterally, intranasally or topically adminstering to the animal an interferon-inducing effective amount of composition containing as the essential active ingredient a compound of the formula ##STR1## or a non-toxic acid addition salt thereof wherein R.sub.7 and R.sub.8 are each alkyl of from 12 to 30 carbon atoms and Z is selected from the group consisting of N-(lower alkyl)-piperazino and N-(W-hydroxy-lower alkyl)-piperazino, said lower alkyl groups having from 1 to 4 carbon atoms.
摘要翻译： 一种在脊椎动物中诱导产生内源性干扰素的方法，其包括肠胃外，鼻内或局部施用给动物干扰素诱导的有效量的组合物，其含有作为必需活性成分的式IMA化合物或非 - 其中R 7和R 8各自为12至30个碳原子的烷基，Z选自N-（低级烷基） - 哌嗪基和N-（W-羟基 - 低级烷基） - 哌嗪基， 所述低级烷基具有1至4个碳原子。
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公开(公告)号：US4258061A
公开(公告)日：1981-03-24
申请号：US877116
申请日：1978-02-13
IPC分类号： C07C41/22 , C07C43/225 , C07C229/38 , C07C275/14 , C07C291/04 , C07D317/58 , A61K31/13 , A61K31/135 , A61K31/495
CPC分类号： C07D317/58 , C07C229/38 , C07C275/14 , C07C291/04 , Y10S514/889
摘要： Combating viral infections in vertebrate animals by administering to the animals a monoamine, a diamine or a triamine.
摘要翻译： 通过向动物施用单胺，二胺或三胺来防治脊椎动物的病毒感染。
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公开(公告)号：US4087552A
公开(公告)日：1978-05-02
申请号：US687514
申请日：1976-05-18
IPC分类号： C07C275/14 , A61K31/135 , A61K31/205 , A61K31/495
CPC分类号： C07C275/14
摘要： Combating viral infections in vertebrate animals by administering to the animals an amine selected from those having the formulae: ##STR1## and the non-toxic acid addition salts thereof wherein R.sub.1 is selected from the group consisting of alkyl of from 1 to 20 carbon atoms, aralkyl, aryloxyalkyl, hydroxyalkyl of from 2 to 8 carbon atoms and ##STR2## R.sub.2 is selected from the group consisting of alkyl of from 12 to 20 carbon atoms, aralkyl and aryloxyalkyl of from 12 to 24 carbon atoms and ##STR3## R.sup.o is alkoxy of from 1 to 18 carbon atoms; EACH OF R' and R" is selected from the group consisting of hydrogen, alkyl, alkoxy of from 1 to 18 carbon atoms; R' and R" when taken together are methylenedioxy;Provided that the total number of carbon atoms in R.sup.o, R' and R" is from 5 to 48;R.sub.3 is selected from the group consisting of hydrogen, alkyl of from 1 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, phenylcarbamoyloxy(lower alkyl), .omega.-carboxyalkanoyloxy(lower alkyl), allyl, alkanoyl of from 1 to 6 carbon atoms, alkanoyloxy(lower alkyl), carbo(lower alkoxy)lower alkyl, carboxy(lower alkyl), alkoxy(lower alkyl) and gem-di(lower alkoxy)lower alkyl;R.sub.4 is selected from the group consisting of hydrogen, alkyl of from 1 to 8 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, carbo(lower alkoxy)lower alkyl, alkanoyloxy(lower alkyl), carboxy(lower alkyl), alkoxy(lower alkyl), phenyl-carbamoyloxy(lower alkyl), .omega.-carboxyalkanoyloxy(lower alkyl), allyl, dihydroxyalkyl of from 3 to 8 carbon atoms, and morpholinoethyl; with the proviso that no more than two of the R variables are hydroxyalkyl;R.sub.3 and R.sub.4 when taken together with the nitrogen to which they are attached are morpholino;X is selected from the group consisting of straight chain alkylene of from 2 to 6 carbon atoms and ##STR4## X' is selected from the group consisting of X, phenylenedimethylene and ##STR5## m is 0 or 1, with the provisos that only one of X and X'is ##STR6## and when X' is phenylenedimethylene, m is 0; Y is selected from the group consisting of straight chain alkylene of from 2 to 8 carbon atoms and phenylenedimethylene;A is selected from the group consisting of hydrogen, cyano, hydroxy, alkoxy of from 1 to 20 carbon atoms, alkanoyloxy of from 2 to 20 carbon atoms, phenylcarbamoyloxy, chloro, bromo, .omega.-carboxyalkanoyloxy(lower alkyl), alkanoyloxy of from 1 to 6 carbon atoms, carbo(lower alkoxy) and alkanoylthio of from 2 to 20 carbon atoms and alkylthio of from 1 to 20 carbon atoms;R.sub.5 is selected from the group consisting of hydrogen, alkyl of from 1 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, (lower alkoxy)lower alkyl and ##STR7## R.sub.6 is selected from the group consisting of hydrogen, alkyl of from 12 to 20 carbon atoms, hydroxyalkyl of from 2 to 8 carbon atoms, (lower alkoxy)lower alkyl and ##STR8## R.sub.7 is selected from the group consisting of alkyl of from 12 to 20 carbon atoms and ##STR9## R.sub.8 is selected from the group consisting of alkyl of from 1 to 20 carbon atoms and ##STR10## each of p and n is 0 or an integer from 1 to 6, with the proviso that the sum of p and n is no greater than 6; andZ is selected from the group consisting of .omega.-carboxy(lower alkyl), morpholino, piperidino, piperazino, N-(.omega.-hydroxy lower alkyl)piperazino and N-(lower alkyl)piperazino.
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5.发明授权
公开(公告)号：US4007184A
公开(公告)日：1977-02-08
申请号：US621219
申请日：1975-10-09
IPC分类号： A23K1/16 , A23K1/18 , C07D263/14 , C07D241/52
CPC分类号： C07D263/14 , A23K20/137 , A23K50/30
摘要： Novel alkyl esters of quinoxaline-di-N-oxide-2-carboxylic acid substituted on the alkyl portion of the ester by hydroxy, acyloxy, N-alkyl carbamyloxy, dialkylaminoacyloxy, carboxyacyloxy, alkoxycarbonyloxy, haloacyloxy, amino and mono- and disubstituted amino, useful as antibacterial agents and in promoting growth and improving feed efficiency of animals in general.
摘要翻译： 通过羟基，酰氧基，N-烷基氨基甲酰氧基，二烷基氨基酰氧基，羧基酰氧基，烷氧基羰基氧基，卤代酰氧基，氨基和一取代和二取代的氨基取代的酯的烷基部分上的喹喔啉二-N-氧化物-2-羧酸的新型烷基酯， 通常用作抗菌剂和促进动物的生长和提高饲料效率。
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公开(公告)号：US3966936A
公开(公告)日：1976-06-29
申请号：US581830
申请日：1975-05-29
IPC分类号： A61K31/495 , A61K31/505
CPC分类号： A61K31/505 , A61K31/495
摘要： A series of novel 4-piperazino-6,7-dialkoxyquinazolines and 1-piperazino-6,7-dialkoxyisoquinolines have been prepared, including their acid addition salts. These compounds are useful in therapy as bronchodilators and as smooth muscle relaxants. Methods for their preparation from known compounds are provided.
摘要翻译： 已经制备了一系列新的4-哌嗪基-6,7-二烷氧基喹唑啉和1-哌嗪基-6,7-二烷氧基异喹啉，包括它们的酸加成盐。 这些化合物可用于治疗支气管扩张剂和平滑肌松弛剂。 提供了从已知化合物制备的方法。
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