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公开(公告)号：US07780827B1
公开(公告)日：2010-08-24
申请号：US11158772
申请日：2005-06-22
申请人： Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, Jr.
发明人： Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, Jr.
IPC分类号： G01N27/327
CPC分类号： G01N33/5438 , G01N27/3272 , G01N33/48771 , G01N2035/00811
摘要： The present invention relates to a biosensor. The biosensor includes a support substrate, an electrically conductive coating positioned on the support substrate, the coating being formed to define electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and a cover cooperating with the support substrate to define a channel. At least a portion of the electrodes are positioned in the channel.
摘要翻译： 本发明涉及生物传感器。 所述生物传感器包括支撑衬底，位于所述支撑衬底上的导电涂层，所述涂层被形成以限定电极和编码图案，其中所述导电涂层和所述衬底之间存在足够的对比度，使得所述代码图案是可辨别的，以及 与所述支撑基板配合以限定通道的盖。 至少一部分电极定位在通道中。
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公开(公告)号：US20080314882A1
公开(公告)日：2008-12-25
申请号：US10976740
申请日：2004-10-29
申请人： Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, JR.
发明人： Raghbir S. Bhullar , Henning Groll , John T. Austera , Douglas P. Walling , Timothy L. Ranney , James L. Pauley, JR.
IPC分类号： C12M3/00
CPC分类号： G01N33/5438 , G01N27/3272 , G01N33/48771 , G01N2035/00811
摘要： The present invention relates to a method of forming a biosensor. The method includes providing a substrate coated with a electrically conductive material, ablating the electrically conductive material to form electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and applying a reagent to at least one of the electrodes.
摘要翻译： 本发明涉及形成生物传感器的方法。 该方法包括提供涂覆有导电材料的基材，烧蚀导电材料以形成电极和编码图案，其中在导电涂层和基板之间存在足够的对比度，使得代码图案是可辨别的，并且施加试剂 至少一个电极。
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公开(公告)号：US20120097536A1
公开(公告)日：2012-04-26
申请号：US13342268
申请日：2012-01-03
IPC分类号： G01N27/327
CPC分类号： G01N27/327 , G01N27/3273 , G01N27/3274 , G01N27/4163
摘要： The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.
摘要翻译： 本发明提供了一种测试条，用于在将测试条配合到适当的测试仪器时测量生物流体中感兴趣的信号，其中测试条和测试仪包括用于验证测试条迹线的完整性的结构， 测量测试条迹线的寄生电阻，并对施加到测试条上的电压进行补偿，以考虑测试条迹线中的寄生电阻损耗。
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公开(公告)号：US08140294B2
公开(公告)日：2012-03-20
申请号：US12479212
申请日：2009-06-05
IPC分类号： G01K13/00
CPC分类号： A61B5/14532 , A61B5/1495 , A61B5/6887 , A61B2560/0252 , A61B2562/0295 , G01K7/42
摘要： Methods of estimating the temperature of a reaction site on a measurement strip in a blood glucose measuring devices are provided. In one embodiment, a method includes determining an activation initiation time, an activation duration time, a thermal magnitude and a temperature elevation for heat generating components within a device. The temperature elevation for each of the heat generating components is determined at least in part by an impulse response matrix [Xi], the activation initiation time, the activation duration time and the thermal magnitude for each of the heat generating components. The method further includes determining a total temperature elevation of the glucose measuring device by summing the temperature elevation of each of the heat generating components, reading a temperature value provided by the temperature measuring element, and determining a reaction site temperature estimation by subtracting the total temperature elevation from the temperature value provided by the temperature measuring element.
摘要翻译： 提供了用于估计血糖测量装置中的测量条上的反应部位的温度的方法。 在一个实施例中，一种方法包括确定装置内的发热部件的激活开始时间，激活持续时间，热量值和温度升高。 每个发热部件的温度升高至少部分地由每个发热部件的脉冲响应矩阵X，激活起始时间，激活持续时间和热量值决定。 该方法还包括通过将每个发热部件的温度升高相加来确定葡萄糖测量装置的总温度升高，读取由温度测量元件提供的温度值，并通过减去总温度来确定反应部位温度估计 由温度测量元件提供的温度值提升。
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5.发明授权Densitometer with automatic gain and reference value adjustment of analog waveform 失效密度计具有模拟波形的自动增益和参考值调整
公开(公告)号：US4697236A
公开(公告)日：1987-09-29
申请号：US710741
申请日：1985-03-11
CPC分类号： G01N21/5911 , G01N2021/5915 , G01N2201/127
摘要： A computer controlled diagnostic densitometer for analyzing optical density patterns of blood samples or the like scans a sample and generates an analog waveform signal representative of the scanned optical density pattern. The analog signal is amplified, digitized, stored in a memory and is later read from memory to reconstruct a visual display of the waveform for analysis. Several types of optical density pattens may be scanned which result in analog signals of different amplitudes and signal-to-background noise ratios. An improved amplification system automatically preadjusts the gain and reference value of the analog signal prior to digitization in order to substantially eliminate background noise in the signal and produce substantially full scale analog signal values. The gain and reference value preadjustments are performed by a pair of corresponding multipliers which multiply the analog signal by memory-stored digital data which is unique to the type of optical density pattern being scanned. The gain and reference voltage may also be manually preadjusted in order to assure sample-to-sample analysis consistency for samples from the same patient.
摘要翻译： 用于分析血液样本等的光密度模式的计算机控制诊断浓度计扫描样品并产生表示扫描的光密度模式的模拟波形信号。 模拟信号被放大，数字化，存储在存储器中，并且随后从存储器读取以重构用于分析的波形的可视显示。 可以扫描几种类型的光密度图案，其产生不同幅度和信号对背景噪声比的模拟信号。 改进的放大系统在数字化之前自动预调制模拟信号的增益和参考值，以便基本上消除信号中的背景噪声并产生基本上满量程的模拟信号值。 增益和参考值预调整由一对相应的乘法器执行，乘法器将模拟信号乘以存储器存储的数字数据，该数字数据与被扫描的光密度模式的类型是唯一的。 增益和参考电压也可以手动预调整，以确保来自同一患者的样品的样品与样品分析的一致性。
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公开(公告)号：US20130027064A1
公开(公告)日：2013-01-31
申请号：US13194031
申请日：2011-07-29
申请人： John T. Austera , Terry A. Beaty , Abner D. Joseph , Nathan E. Manlove , Steven K. Moore , James L. Pauley, JR. , Randall K. Riggles
发明人： John T. Austera , Terry A. Beaty , Abner D. Joseph , Nathan E. Manlove , Steven K. Moore , James L. Pauley, JR. , Randall K. Riggles
IPC分类号： G01R27/08
CPC分类号： G01N27/3272 , G01N33/48771
摘要： An analyte test sensor strip is disclosed having information coded thereon as well as a method of forming the same and conducting an analyte test using the analyte test sensor strip. Information relating to an attribute of the strip or batch/lot of strips may be coded based on resistance values pertaining to electrical aspects of the strip, such as a primary resistive element and a secondary resistive element, the secondary resistive element having one of a plurality of states defined by a location of a closed tap to form a unique resistive path for the secondary resistive element that includes a portion of the primary resistive element depending on the location of the closed tap. The states may be formed on the strip by a secondary processing step in the manufacture of the strip in which a plurality of taps are severed leaving only one tap in a closed state.
摘要翻译： 公开了一种分析物测试传感器带，其具有编码信息的方法以及其形成方法，并使用分析物测试传感器条进行分析物测试。 可以基于条带的电气方面的电阻值（例如主要电阻元件和次级电阻元件）来编码与条带或批/条带的属性有关的信息，次电阻元件具有多个 的状态由闭合抽头的位置限定，以形成用于辅助电阻元件的唯一电阻性通路，该电阻元件包括主电阻元件的一部分，取决于封闭抽头的位置。 这些状态可以通过二次加工步骤形成在条带的制造中，其中多个抽头被切断，在关闭状态下仅留下一个龙头。
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公开(公告)号：US08361291B2
公开(公告)日：2013-01-29
申请号：US13342268
申请日：2012-01-03
IPC分类号： G01N27/416 , G01N27/327
CPC分类号： G01N27/327 , G01N27/3273 , G01N27/3274 , G01N27/4163
摘要： The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.
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8.发明申请METHODS AND SYSTEMS FOR ADJUSTING AN INSULIN DELIVERY PROFILE OF AN INSULIN PUMP 有权用于调节胰岛素泵的胰岛素递送特性的方法和系统公开(公告)号：US20120078221A1
公开(公告)日：2012-03-29
申请号：US13311607
申请日：2011-12-06
CPC分类号： G06F19/3468 , A61M5/14244 , A61M2205/35 , A61M2205/3576 , A61M2205/3584 , A61M2205/3592 , G06F19/00
摘要： Systems and methods are disclosed for adjusting the delivery times of an insulin delivery profile of an insulin pump, wherein the insulin pump is operable to automatically deliver insulin to a person having diabetes based on an operating time of the internal clock and a delivery time of an insulin delivery profile. The method may comprise receiving a local time zone time from an external local clock, determining whether the operating time of the internal clock differs from the local time zone time by at least a first predetermined amount of time, requesting the person provide a time adjustment value when the operating time of the internal clock differs from the local time zone time by at least the first predetermined amount of time, receiving the time adjustment value from the person, and adjusting the delivery times of the insulin delivery profile based on the time adjustment value when received.
摘要翻译： 公开了用于调整胰岛素泵的胰岛素递送曲线的递送时间的系统和方法，其中所述胰岛素泵可操作以基于所述内部时钟的操作时间自动地向具有糖尿病的人递送胰岛素，并且所述输送时间为 胰岛素输送谱。 该方法可以包括从外部本地时钟接收本地时区时间，确定内部时钟的操作时间是否与本地时区时间不同至少第一预定时间量，请求该人提供时间调整值 当内部时钟的操作时间与本地时区时间不同时，至少第一预定时间量，从人接收时间调整值，并且基于时间调整值调整胰岛素输送简档的传送时间 收到时。
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公开(公告)号：US20100307916A1
公开(公告)日：2010-12-09
申请号：US12479212
申请日：2009-06-05
CPC分类号： A61B5/14532 , A61B5/1495 , A61B5/6887 , A61B2560/0252 , A61B2562/0295 , G01K7/42
摘要： Methods of estimating the temperature of a reaction site on a measurement strip in a blood glucose measuring devices are provided. In one embodiment, a method includes determining an activation initiation time, an activation duration time, a thermal magnitude and a temperature elevation for heat generating components within a device. The temperature elevation for each of the heat generating components is determined at least in part by an impulse response matrix [Xi], the activation initiation time, the activation duration time and the thermal magnitude for each of the heat generating components. The method further includes determining a total temperature elevation of the glucose measuring device by summing the temperature elevation of each of the heat generating components, reading a temperature value provided by the temperature measuring element, and determining a reaction site temperature estimation by subtracting the total temperature elevation from the temperature value provided by the temperature measuring element.
摘要翻译： 提供了用于估计血糖测量装置中的测量条上的反应部位的温度的方法。 在一个实施例中，一种方法包括确定装置内的发热部件的激活开始时间，激活持续时间，热量值和温度升高。 每个发热部件的温度升高至少部分地由每个发热部件的脉冲响应矩阵X，激活起始时间，激活持续时间和热量值决定。 该方法还包括通过将每个发热部件的温度升高相加来确定葡萄糖测量装置的总温度升高，读取由温度测量元件提供的温度值，并通过减去总温度来确定反应部位温度估计 由温度测量元件提供的温度值提升。
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公开(公告)号：US20090251158A1
公开(公告)日：2009-10-08
申请号：US12484603
申请日：2009-06-15
IPC分类号： G01R27/08
CPC分类号： G01N27/327 , G01N27/3273 , G01N27/3274 , G01N27/4163
摘要： The present invention provides a test strip for measuring a signal of interest in a biological fluid when the test strip is mated to an appropriate test meter, wherein the test strip and the test meter include structures to verify the integrity of the test strip traces, to measure the parasitic resistance of the test strip traces, and to provide compensation in the voltage applied to the test strip to account for parasitic resistive losses in the test strip traces.
摘要翻译： 本发明提供了一种测试条，用于在将测试条配合到适当的测试仪器时测量生物流体中感兴趣的信号，其中测试条和测试仪包括用于验证测试条迹线的完整性的结构， 测量测试条迹线的寄生电阻，并对施加到测试条上的电压进行补偿，以考虑测试条迹线中的寄生电阻损耗。
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