利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.016 秒)

    Prostaglandin compositions and methods of treatment for male erectile dysfunction
    1.
    发明授权
    Prostaglandin compositions and methods of treatment for male erectile dysfunction 有权
    前列腺素组合物和男性勃起功能障碍治疗方法

    公开(公告)号：US07105571B2

    公开(公告)日：2006-09-12

    申请号：US10236485

    申请日：2002-09-06

    申请人： James L. Yeager ,  Nadir Büyüktimkin ,  Servet Büyüktimkin

    发明人： James L. Yeager ,  Nadir Büyüktimkin ,  Servet Büyüktimkin

    IPC分类号： A61K31/5575 ,  A61K47/36 ,  A61K31/736 ,  A61K9/02

    CPC分类号： A61K9/0014 ,  A61K9/0034 ,  A61K31/557 ,  A61K31/5575 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/183 ,  A61K47/36 ,  Y10S514/946 ,  Y10S514/947 ,  A61K2300/00

    摘要： The invention provides methods and compositions for treating erectile dysfunction. The methods include the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a vasoactive prostaglandin composition of a semi-solid consistency. The composition comprises a vasoactive prostaglandin, a penetration enhancer, a shear-thinning polysaccharide, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N-substituted amino)-alkanoate ester, a (N-substituted amino)-alkanol alkanoate, or a mixture of these enhancers. The lipophilic compound may be an aliphatic C1 to C8 alcohol, aliphatic C2 to C30 ester, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system providing a buffered pH value for said composition in the range of about 3 to about 7.4.

    摘要翻译： 本发明提供了治疗勃起功能障碍的方法和组合物。 所述方法包括在患者的窝窝内放置有效勃起诱导量的半固体稠度的血管活性前列腺素组合物的步骤。 组合物包含血管活性前列腺素，渗透增强剂，剪切稀化多糖，亲脂性化合物和酸性缓冲体系。 渗透促进剂是烷基-2-（N-取代氨基） - 烷酸酯，（N-取代氨基） - 链烷酸烷基酯或这些增强剂的混合物。 亲油性化合物可以是C 8脂肪族C 1至C 8醇，脂肪族C 2〜C 30脂肪酸酯， 与C 30酯的脂肪族C 8或它们的混合物。 该组合物包括提供约3至约7.4范围内所述组合物的缓冲pH值的缓冲系统。

    Prostaglandin compositions and methods of treatment for male erectile dysfunction
    2.
    发明授权
    Prostaglandin compositions and methods of treatment for male erectile dysfunction 有权
    前列腺素组合物和男性勃起功能障碍治疗方法

    公开(公告)号：US06323241B1

    公开(公告)日：2001-11-27

    申请号：US09480738

    申请日：2000-01-10

    申请人： James L. Yeager ,  Nadir Buyuktimkin ,  Servet Buyuktimkin

    发明人： James L. Yeager ,  Nadir Buyuktimkin ,  Servet Buyuktimkin

    IPC分类号： A61K3119

    CPC分类号： A61K9/0014 ,  A61K9/0034 ,  A61K31/557 ,  A61K31/5575 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/183 ,  A61K47/36 ,  Y10S514/946 ,  Y10S514/947 ,  A61K2300/00

    摘要： The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin E1 composition of a semi-solid consistency. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.

    摘要翻译： 本发明提供了治疗勃起功能障碍的方法，其包括在患者的窝窝内放置有效勃起诱导量的半固体一致性的前列腺素E1组合物的步骤。 组合物包含前列腺素E1，渗透促进剂，多糖胶，亲脂性化合物和酸性缓冲体系。 渗透促进剂是烷基-2-（N，N-二取代的氨基） - 烷酸酯，（N，N-二取代的氨基） - 烷醇链烷酸酯或它们的混合物。 亲脂性化合物可以是脂肪族C 1〜C 8醇，脂肪族C 8〜C 30酯，或它们的混合物。 该组合物包括能够提供约3至约7.4范围内所述组合物的缓冲pH值的缓冲系统。

    Medicament dispenser
    3.
    发明授权
    Medicament dispenser 有权
    药剂分配器

    公开(公告)号：US06224573B1

    公开(公告)日：2001-05-01

    申请号：US09232360

    申请日：1999-01-15

    申请人： James L. Yeager ,  Joseph Y. Mo

    发明人： James L. Yeager ,  Joseph Y. Mo

    IPC分类号： A61M500

    CPC分类号： A61F9/0008 ,  A61M31/00

    摘要： A disposable applicator for dispensing a desired quantity of a substantially non-runny medicant medicament, including a housing, a plunger and a replaceable cap. The housing is generally tubular having opposing proximal and distal ends and a tapered inner surface extending therebetween. The distal end terminates in a dispensing nozzle that defines a dispensing passageway in substantial coaxial alignment with the housing, while the inner surface has an alignment device. The plunger has a peripheral edge and is configured for axial movement within the housing, where the peripheral edge is aligned by the alignment device and slidingly guided by the inner surface, supporting the plunger therein. The plunger is configured for slidable advancement toward the dispensing opening by exertion of force by a user, so as to urge the medicament through the passageway.

    摘要翻译： 一种用于分配所需量的基本上非流动性药物的一次性施用器，包括壳体，柱塞和可更换盖。 壳体通常是管状的，具有相对的近端和远端以及在其间延伸的锥形内表面。 远端终止于分配喷嘴，其限定与壳体基本同轴对准的分配通道，而内表面具有对准装置。 柱塞具有周缘并被构造成在壳体内轴向移动，其中周边边缘由对准装置对准并且被内表面滑动地引导，将柱塞支撑在其中。 柱塞被构造成通过使用者的力而朝着分配开口滑动前进，以便促使药物通过通道。

    Boot warmer
    5.
    发明授权
    Boot warmer 失效
    靴子暖和

    公开(公告)号：US6148545A

    公开(公告)日：2000-11-21

    申请号：US405093

    申请日：1999-09-27

    申请人： James L. Yeager, Jr.

    发明人： James L. Yeager, Jr.

    IPC分类号： A43D3/14 ,  A47L23/20 ,  A43B7/02

    CPC分类号： A43D999/00 ,  A43D3/1408 ,  A47L23/205

    摘要： A foot warmer which has a shape to fit into a boot and an insulating foam adjacent the top of the warmer. Below the insulating foam is a heat retaining material that can be heated in a microwave.

    摘要翻译： 一种脚部加温器，其具有适合于靴子的形状和邻近保温器顶部的绝缘泡沫。 绝缘泡沫下面是可以在微波炉中加热的保温材料。

    Compositions and methods for amelioration of human female sexual dysfunction
    6.
    发明授权
    Compositions and methods for amelioration of human female sexual dysfunction 有权
    用于改善人类女性性功能障碍的组合和方法

    公开(公告)号：US06486207B2

    公开(公告)日：2002-11-26

    申请号：US09208965

    申请日：1998-12-10

    申请人： James L. Yeager ,  Nadir Buyuktimkin ,  Servet Buyuktimkin

    发明人： James L. Yeager ,  Nadir Buyuktimkin ,  Servet Buyuktimkin

    IPC分类号： A61K31557

    CPC分类号： A61K9/0034 ,  Y10S514/929 ,  Y10S514/946 ,  Y10S514/947 ,  Y10S514/967

    摘要： The invention provides a composition suitable for topical application comprising: an effective amount of a prostaglandin, a polymer thickener, a lipophilic component, and a buffer system. In another embodiment, the invention provides a composition suitable for topical application comprising: an effective amount of a vasoactive agent, a polymer thickener, a lipophilic component, and a buffer system. The invention also provides methods of ameliorating female sexual dysfunction. Also provided are methods of increasing female sexual arousal and methods of enhancing female sexual response.

    摘要翻译： 本发明提供了适用于局部应用的组合物，其包含：有效量的前列腺素，聚合物增稠剂，亲脂性组分和缓冲体系。 在另一个实施方案中，本发明提供适用于局部应用的组合物，其包含：有效量的血管活性剂，聚合物增稠剂，亲脂性组分和缓冲体系。 本发明还提供了改善女性性功能障碍的方法。 还提供了增加女性性唤起的方法和增强女性性反应的方法。

    Topical compositions containing prostaglandin E1
    7.
    发明授权
    Topical compositions containing prostaglandin E1 有权
    含有前列腺素E1的局部组合物

    公开(公告)号：US06414028B1

    公开(公告)日：2002-07-02

    申请号：US09542668

    申请日：2000-04-04

    申请人： Servet Büyüktimkin ,  Nadir Büyüktimkin ,  James L. Yeager

    发明人： Servet Büyüktimkin ,  Nadir Büyüktimkin ,  James L. Yeager

    IPC分类号： A01N3708

    CPC分类号： A61K9/0034 ,  A61K9/0014 ,  A61K31/557 ,  A61K31/5575 ,  A61K47/14 ,  A61K47/18 ,  A61K47/183 ,  A61K47/36 ,  Y10S514/946 ,  Y10S514/947

    摘要： A topical composition of a semi-solid consistency suitable is provided for transdermal application of prostaglandin E1. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an acid addition salt of an alkyl-2-(substituted amino)-alkanoate ester, of a (substituted amino)-alkanol alkanoate, or of a mixture thereof. The lipophilic compound may be an aliphatic C1 to C8 alcohol, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.

    摘要翻译： 提供适用于半固体稠度的局部组合物用于经皮施用前列腺素E1。 组合物包含前列腺素E1，渗透促进剂，多糖胶，亲脂性化合物和酸性缓冲体系。 渗透促进剂是烷基-2-（取代的氨基） - 烷酸酯，（取代的氨基） - 链烷酸烷基酯或它们的混合物的酸加成盐。 亲脂性化合物可以是脂肪族C 1〜C 8醇，脂肪族C 8〜C 30酯，或它们的混合物。 该组合物包括能够提供约3至约7.4范围内所述组合物的缓冲pH值的缓冲系统。

    Prostaglandin compositions and methods of treatment for male erectile dysfunction
    9.
    发明授权
    Prostaglandin compositions and methods of treatment for male erectile dysfunction 有权
    前列腺素组合物和男性勃起功能障碍治疗方法

    公开(公告)号：US06693135B2

    公开(公告)日：2004-02-17

    申请号：US09947617

    申请日：2001-09-06

    申请人： James L. Yeager ,  Nadir Buyuktimkin ,  Servet Buyuktimkin

    发明人： James L. Yeager ,  Nadir Buyuktimkin ,  Servet Buyuktimkin

    IPC分类号： A61K315575

    CPC分类号： A61K47/183 ,  A61K9/0014 ,  A61K9/0034 ,  A61K31/557 ,  A61K31/5575 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/36 ,  A61K2300/00

    摘要： The invention provides methods of treating erectile dysfunction comprising the step of placing within the fossa navicularis of the patient an effective erection-inducing amount of a prostaglandin E1 composition of a semi-solid consistency, as well as suitable applicators. The composition comprises prostaglandin E1, a penetration enhancer, a polysaccharide gum, a lipophilic compound, and an acidic buffer system. The penetration enhancer is an alkyl-2-(N,N-disubstituted amino)-alkanoate ester, an (N,N-disubstituted amino)-alkanol alkanoate, or a mixture of these. The lipophilic compound may be an aliphatic C1 to C8 alcohol, aliphatic C2 to C30 ester, an aliphatic C8 to C30 ester, or a mixture of these. The composition includes a buffer system capable of providing a buffered pH value for said composition in the range of about 3 to about 7.4.

    摘要翻译： 本发明提供治疗勃起功能障碍的方法，其包括将有效勃起诱导量的半固体稠度的前列腺素E1组合物以及合适的施用器置于患者的窝窝内的步骤。 组合物包含前列腺素E1，渗透促进剂，多糖胶，亲脂性化合物和酸性缓冲体系。 渗透促进剂是烷基-2-（N，N-二取代的氨基） - 烷酸酯，（N，N-二取代的氨基） - 烷醇链烷酸酯或它们的混合物。 亲油性化合物可以是脂肪族C 1〜C 8醇，脂肪族C 2〜C 30酯，脂肪族C 8〜C 30酯，或它们的混合物。 该组合物包括能够提供约3至约7.4范围内所述组合物的缓冲pH值的缓冲系统。