公开(公告)号：US5616782A

公开(公告)日：1997-04-01

申请号：US558825

申请日：1995-11-16

Applicant: Ralph Thompson ,  Ned M. Rockwell ,  Ann M. Michels ,  William R. Mohring ,  Kevin C. Kolbe ,  J. Duke Seibold ,  James M. Butterwick

Inventor： Ralph Thompson ,  Ned M. Rockwell ,  Ann M. Michels ,  William R. Mohring ,  Kevin C. Kolbe ,  J. Duke Seibold ,  James M. Butterwick

IPC: A61K8/46 ,  A61Q11/00 ,  C07C303/02 ,  C07C303/32 ,  C07C309/17 ,  C11D1/12 ,  C11D1/28 ,  C07C301/00 ,  C07C305/04

CPC classification number: A61Q11/00 ,  A61K8/466 ,  C07C303/02 ,  C07C303/32 ,  C11D1/28

Abstract: Disclosed are alkyl sulfoacetate compositions comprising a sulfonated ester of the formula:RO(CH.sub.2 CHR.sub.1 O).sub.n COCH.sub.2 SO.sub.3 MwhereR represents straight chain alkyl having from about 6 to 20 carbon atoms;R.sub.1 is hydrogen, methyl, or ethyl;n is 0, or an integer of from 1 to 20; andM represents a cation;the composition being substantially free from monochloroacetate salts and monochloroacetic acid. These compositions are prepared by reacting an alkyl chloroester of the formula RO(CH.sub.2 CHR.sub.1 O).sub.n COCH.sub.2 Cl where R, R.sub.1 and n are as defined above with an excess of sodium sulfite in the presence of a sulfitation catalyst at a temperature of at least about 75.degree. C. Also disclosed are oral care compositions comprising these surfactant compositions.

Abstract translation: 公开了包含下式的磺化酯的磺基乙酸烷基酯组合物：RO（CH 2 CHR 1 O）n COCH 2 SO 3 M其中R表示具有约6至20个碳原子的直链烷基; R1是氢，甲基或乙基; n为0，或1〜20的整数。 M表示阳离子; 该组合物基本上不含一氯乙酸盐和一氯乙酸。 这些组合物通过在硫酸催化剂存在下，在至少约75℃的温度下使式RO（CH 2 CHR 1 O）n COCH 2 Cl的烷基氯酯（其中R，R 1和n如上定义）与过量的亚硫酸钠反应制备 还公开了包含这些表面活性剂组合物的口腔护理组合物。