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公开(公告)号：US20160046600A1
公开(公告)日：2016-02-18
申请号：US14777481
申请日：2014-03-13
Applicant: Wenying CHAI , Charlotte DECKHUT , Curt A. DVORAK , Wendy ECCLES , James P. EDWARDS , Steven D. GOLDBERG , Paul J. KRAWCZUK , Alec D. LEBSACK , Jing LIU , Virginia M. TANIS , Kyle T. TARANTINO , JANSSEN PHARMACEUTICA NV
Inventor： Wenying Chai , Charlotte Deckhut , Curt A. Dvorak , Wendy Eccles , James P. Edwards , Steven D. Goldberg , Paul J. Krawczuk , Alec D. Lebsack , Jing Liu , Virginia M. Tanis , Kyle T. Tarantino
IPC: C07D401/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D413/14 , C07D401/14
CPC classification number: C07D417/14 , A61K31/428 , A61K31/4709 , A61K31/4725 , A61K31/506 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/12
Abstract: The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein ring A, R1, R5 and R6 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
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公开(公告)号：US08937075B2
公开(公告)日：2015-01-20
申请号：US13456165
申请日：2012-04-25
Applicant: James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
Inventor： James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
IPC: A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00 , C07D495/04 , C07D493/04 , C07D519/00
CPC classification number: C07D495/04 , C07D493/04 , C07D519/00
Abstract: Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
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公开(公告)号：US08927555B2
公开(公告)日：2015-01-06
申请号：US13456180
申请日：2012-04-25
Applicant: James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
Inventor： James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
IPC: A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00 , C07D495/04 , C07D493/04 , C07D519/00
CPC classification number: C07D495/04 , C07D493/04 , C07D519/00
Abstract: Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
Abstract translation: 描述了噻吩和呋喃嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于调节组胺H 4受体活性的药物组合物和方法，以及用于治疗由H 4受体活性如炎症介导的疾病状态，病症和病况。
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4.发明授权Aryl-substituted bridged or fused diamines as modulators of leukotriene A ydrolase 有权芳基取代的桥连或稠合二胺作为白三烯A型调质剂公开(公告)号：US08344008B2
公开(公告)日：2013-01-01
申请号：US13091498
申请日：2011-04-21
Applicant: Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alexandro Santillán, Jr.
Inventor： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alexandro Santillán, Jr.
IPC: A61K31/425
CPC classification number: C07D487/08 , C07D417/12 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/04
Abstract: Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.
Abstract translation: 芳基取代的桥连或稠合二胺化合物，含有它们的药物组合物，以及使用该化合物和药物组合物用于白三烯A4水解酶（LTA4H或LTA4H）调节和治疗由LTA4H活性介导的疾病状态，障碍和病症的方法 ，例如过敏，哮喘，自身免疫性疾病，瘙痒炎，炎性肠病，溃疡性结肠炎和心血管疾病，包括动脉粥样硬化和预防心肌梗死。
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公开(公告)号：US08343989B2
公开(公告)日：2013-01-01
申请号：US12816995
申请日：2010-06-16
Applicant: James P. Edwards , David E. Kindrachuk , Christopher M. Mapes , Daniel J. Pippel , Jennifer D. Venable
Inventor： James P. Edwards , David E. Kindrachuk , Christopher M. Mapes , Daniel J. Pippel , Jennifer D. Venable
IPC: C07D401/14 , A61K31/4184
CPC classification number: C07D401/14 , A61K31/4184 , C07D403/14
Abstract: Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for H4 receptor activity modulation and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.
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Patent Agency Ranking
6.发明申请THIENO- ADN FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR 审中-公开组胺H4受体的THIENO-ADN FURO-PYRIMIDINE调节剂公开(公告)号：US20120214792A1
公开(公告)日：2012-08-23
申请号：US13456180
申请日：2012-04-25
Applicant: James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
Inventor： James P. Edwards , Danielle K. Neff , Deborah M. Smith , Jennifer D. Venable
IPC: A61K31/519 , C07D491/048 , C07D243/08 , A61K31/551 , A61P37/08 , A61P11/06 , A61P27/02 , A61P11/00 , A61P9/10 , A61P19/02 , A61P1/00 , A61P1/04 , A61P17/06 , A61P17/00 , A61P37/06 , A61P7/06 , C07D495/04
CPC classification number: C07D495/04 , C07D493/04 , C07D519/00
Abstract: Thieno- and furo-pyrimidine compounds are described, which are useful as H4 receptor modulators. Such compounds may be used in pharmaceutical compositions and methods for the modulation of histamine H4 receptor activity and for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, such as inflammation.
Abstract translation: 描述了噻吩和呋喃嘧啶化合物，其可用作H 4受体调节剂。 这些化合物可用于调节组胺H 4受体活性的药物组合物和方法，以及用于治疗由H 4受体活性如炎症介导的疾病状态，病症和病况。
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公开(公告)号：US08017639B2
公开(公告)日：2011-09-13
申请号：US12793951
申请日：2010-06-04
Applicant: Daniel J. Buzard , James P. Edwards , David E. Kindrachuk , Jennifer D. Venable
Inventor： Daniel J. Buzard , James P. Edwards , David E. Kindrachuk , Jennifer D. Venable
IPC: A01N43/50 , A61K31/415 , C07D233/02 , C07D211/00
CPC classification number: C07D471/04 , C07D233/64 , C07D235/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14
Abstract: Imidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor expression, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions.
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公开(公告)号：US07956066B2
公开(公告)日：2011-06-07
申请号：US11704131
申请日：2007-02-08
Applicant: Daniel J. Buzard , James P. Edwards , David E. Kindrachuk , Jennifer D. Venable
Inventor： Daniel J. Buzard , James P. Edwards , David E. Kindrachuk , Jennifer D. Venable
IPC: C07D401/14 , C07D401/04 , A61K31/50
CPC classification number: C07D471/04 , C07D233/64 , C07D235/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14
Abstract: Imidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor expression, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions.
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公开(公告)号：US07956057B2
公开(公告)日：2011-06-07
申请号：US11704123
申请日：2007-02-08
Applicant: Daniel J. Buzard , James P. Edwards , David E. Kindrachuk , Jennifer D. Venable
Inventor： Daniel J. Buzard , James P. Edwards , David E. Kindrachuk , Jennifer D. Venable
IPC: A61K31/497 , C07D241/04 , C07D295/00
CPC classification number: C07D471/04 , C07D233/64 , C07D235/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14
Abstract: Imidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor expression, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions.
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公开(公告)号：US20100261899A1
公开(公告)日：2010-10-14
申请号：US12796858
申请日：2010-06-09
Applicant: Daniel J. Buzard , James P. Edwards , David E. Kindrachuk , Jennifer D. Venable
Inventor： Daniel J. Buzard , James P. Edwards , David E. Kindrachuk , Jennifer D. Venable
IPC: C07D403/12
CPC classification number: C07D471/04 , C07D233/64 , C07D235/18 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D409/14
Abstract: Imidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor expression, and in treating conditions such as inflammation, H4 receptor-mediated conditions, and related conditions.
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