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公开(公告)号:US4415546A
公开(公告)日:1983-11-15
申请号:US262974
申请日:1981-05-12
IPC分类号: A61K38/00 , C07K14/695 , G01N33/74 , G01N33/56 , C07C103/52 , G01N33/58
CPC分类号: G01N33/74 , C07K14/695 , A61K38/00
摘要: A fully steroidogenically active analog of ACTH is disclosed. The analog differs from natural ACTH in that phenylalanine replaces tyrosine in the second position on the peptide chain; and norleucine replaces methionine in the fourth position on the peptide chain. The analog may be iodinated to yield [I]Tyr.sup.2 -Phe.sup.2,Nle.sup.4 -ACTH, which also retains full steroidogenic activity. When labeled with iodine-125 the analog is useful in following steroidogenic processes and also in radioimmunoassays for ACTH.
摘要翻译: 公开了ACTH的完全类固醇生物活性类似物。 该类似物与天然ACTH不同之处在于苯丙氨酸在肽链的第二位置替代酪氨酸; 和正亮氨酸替代肽链上第四位的甲硫氨酸。 类似物可以被碘化以产生[I] Tyr2-Phe2,Nle4-ACTH,其也保留完全的类固醇生成活性。 当用碘-125标记时,类似物可用于以下类固醇生成过程,也用于ACTH的放射免疫测定。