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1.
公开(公告)号:US5559095A
公开(公告)日:1996-09-24
申请号:US789913
申请日:1991-11-12
申请人: George P. Miljanich , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Robert S. Bitner , Donald H. Yamashiro
发明人: George P. Miljanich , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Robert S. Bitner , Donald H. Yamashiro
IPC分类号: A61K38/00 , C07K14/435 , A61K38/16
CPC分类号: C07K14/435 , A61K38/00
摘要: A method and compositions for reducing neuronal damage related to an ischemic condition in a mammalian subject are described. The method includes administration of a voltage-gated calcium channel-blocking compound to the subject, 4-24 hours after the onset of the ischemic condition. Such a calcium channel blocking compound is effective to block norepinephrine release in mammalian CNS neuronal cells and is characterized by specific, high affinity binding to omega-conotoxin MVIIA binding sites. Also disclosed are novel peptide structures useful in the treatment method of the invention.
摘要翻译: 描述了用于减少与哺乳动物受试者的缺血状况相关的神经元损伤的方法和组合物。 该方法包括在缺血状态发作后4-24小时向受试者施用电压门控的钙通道阻断化合物。 这种钙通道阻断化合物有效阻断哺乳动物CNS神经细胞中的去甲肾上腺素释放,其特征在于与ω-芋螺毒素MVIIA结合位点的特异性高亲和力结合。 还公开了可用于本发明的治疗方法的新型肽结构。
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公开(公告)号:US5264371A
公开(公告)日:1993-11-23
申请号:US855269
申请日:1992-03-23
申请人: George P. Miljanich , Robert S. Bitner , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Donald H. Yamashiro , Makoto Tsubokawa
发明人: George P. Miljanich , Robert S. Bitner , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Donald H. Yamashiro , Makoto Tsubokawa
IPC分类号: A61K38/00 , C07K14/435 , G01N33/567 , G01N33/68
CPC分类号: C07K14/435 , A61K38/00
摘要: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.
摘要翻译: 公开了部分纯化的ω-芋螺毒素结合蛋白。 在部分纯化形式或突触体制剂中的蛋白质可用于鉴定在人类患者中用于减少与缺血性疾病如中风有关的神经元损伤的化合物。
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公开(公告)号:US5051403A
公开(公告)日:1991-09-24
申请号:US440094
申请日:1989-11-22
申请人: George P. Miljanich , Robert S. Bitner , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Donald H. Yamashiro
发明人: George P. Miljanich , Robert S. Bitner , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Donald H. Yamashiro
IPC分类号: A61K38/00 , A61P9/10 , A61P25/00 , C07K7/00 , C07K14/435 , C07K14/47 , C07K14/705
CPC分类号: C07K14/435 , A61K38/00
摘要: A method of reducing neuronal damage related to an ischemic condition in a human patient, such as stroke-induced damage, by administration of a binding/inhibitory omega-conotoxin peptide.
摘要翻译: 通过施用结合/抑制性ω-芋螺毒素肽减少与人类患者缺血状况相关的神经元损伤的方法,例如中风诱发的损伤。
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4.
公开(公告)号:US4415546A
公开(公告)日:1983-11-15
申请号:US262974
申请日:1981-05-12
IPC分类号: A61K38/00 , C07K14/695 , G01N33/74 , G01N33/56 , C07C103/52 , G01N33/58
CPC分类号: G01N33/74 , C07K14/695 , A61K38/00
摘要: A fully steroidogenically active analog of ACTH is disclosed. The analog differs from natural ACTH in that phenylalanine replaces tyrosine in the second position on the peptide chain; and norleucine replaces methionine in the fourth position on the peptide chain. The analog may be iodinated to yield [I]Tyr.sup.2 -Phe.sup.2,Nle.sup.4 -ACTH, which also retains full steroidogenic activity. When labeled with iodine-125 the analog is useful in following steroidogenic processes and also in radioimmunoassays for ACTH.
摘要翻译: 公开了ACTH的完全类固醇生物活性类似物。 该类似物与天然ACTH不同之处在于苯丙氨酸在肽链的第二位置替代酪氨酸; 和正亮氨酸替代肽链上第四位的甲硫氨酸。 类似物可以被碘化以产生[I] Tyr2-Phe2,Nle4-ACTH,其也保留完全的类固醇生成活性。 当用碘-125标记时,类似物可用于以下类固醇生成过程,也用于ACTH的放射免疫测定。
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公开(公告)号:US5424218A
公开(公告)日:1995-06-13
申请号:US147714
申请日:1993-11-04
申请人: George P. Miljanich , Robert S. Bitner , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Donald H. Yamashiro
发明人: George P. Miljanich , Robert S. Bitner , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Donald H. Yamashiro
IPC分类号: A61K38/00 , C07K14/435 , A61K49/00 , G01N33/567 , G01N33/68
CPC分类号: C07K14/435 , A61K38/00
摘要: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.
摘要翻译: 公开了部分纯化的ω-芋螺毒素结合蛋白。 在部分纯化形式或突触体制剂中的蛋白质可用于鉴定在人类患者中用于减少与缺血性疾病如中风有关的神经元损伤的化合物。
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6.
公开(公告)号:US5189020A
公开(公告)日:1993-02-23
申请号:US561766
申请日:1990-08-02
申请人: George P. Miljanich , Robert S. Bitner , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Donald H. Yamashiro , Makoto Tsubokawa
发明人: George P. Miljanich , Robert S. Bitner , Stephen S. Bowersox , James A. Fox , Karen L. Valentino , Donald H. Yamashiro , Makoto Tsubokawa
IPC分类号: A61K38/00 , C07K14/435
CPC分类号: C07K14/435 , A61K38/00
摘要: A partially purified omega conotoxin binding protein is disclosed. The protein, either in partially purified form or in a synaptosomal preparation, is useful in identifying compounds for use in reducing neuronal damage related to an ischemic condition, such as stroke, in a human patient.
摘要翻译: 公开了部分纯化的ω-芋螺毒素结合蛋白。 在部分纯化形式或突触体制剂中的蛋白质可用于鉴定在人类患者中用于减少与缺血性疾病如中风有关的神经元损伤的化合物。
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