公开(公告)号：US20070010448A1

公开(公告)日：2007-01-11

申请号：US11519693

申请日：2006-09-12

申请人： Roland Contreras ,  Bart Nelissen ,  Marianne De Backer ,  Walter Luyten ,  Jasmine Viaene ,  Marc Logghe ,  Jorge Vialard

发明人： Roland Contreras ,  Bart Nelissen ,  Marianne De Backer ,  Walter Luyten ,  Jasmine Viaene ,  Marc Logghe ,  Jorge Vialard

IPC分类号： A61K38/16 ,  C07H21/04 ,  C12N15/74 ,  C12N1/18 ,  C07K14/40

CPC分类号： C07K14/40 ,  A61K38/00

摘要： The present invention is concerned with the identification of genes or functional fragments thereof from Candida albicans which are critical for growth and cell division and which genes may be used as selective drug targets to treat Candida albicans associated infections. Novel nucleic acid sequences from Candida albicans are also provided and which encode the polypeptides which are critical for growth of Candida albicans. Methods for the identification of anti-fungal compounds which inhibit fungal or yeast growth are also contemplated.

摘要翻译： 本发明涉及鉴定对于生长和细胞分裂至关重要的白色念珠菌的基因或其功能片段，哪些基因可用作治疗白色念珠菌相关感染的选择性药物靶标。 还提供了来自白色念珠菌的新型核酸序列，其编码对白色念珠菌生长至关重要的多肽。 还考虑了用于鉴定抑制真菌或酵母生长的抗真菌化合物的方法。

公开(公告)号：US20090098243A1

公开(公告)日：2009-04-16

申请号：US11575389

申请日：2005-09-15

申请人： Filip Arnaut ,  Roland Contreras ,  Thierry Dauvrin ,  Guy Vanneste ,  Jasmine Viaene ,  Jacques Claude Eloi Georis

发明人： Filip Arnaut ,  Roland Contreras ,  Thierry Dauvrin ,  Guy Vanneste ,  Jasmine Viaene ,  Jacques Claude Eloi Georis

IPC分类号： A23J3/34 ,  C12N9/02 ,  C12N15/11 ,  C12N15/00 ,  C12N1/19

CPC分类号： A21D8/042 ,  C12N9/0004

摘要： The present invention relates to a new isolated nucleic acid sequence comprising a gene that encodes a new fungal oxidase enzyme, and nucleic acid fragments thereof.It also relates to said new fungal oxidase isolated and purified from Aspergillus ficuum, its amino acid sequence as shown in SEQ ID NO 40 or 41, and functional equivalents or derivatives thereof.The present invention also relates to constructs, vectors and hosts cells comprising a nucleic acid molecule of the invention, as well as methods for producing an oxidase of the invention.The present invention also relates to the use of an oxidase of the invention in industrial processes.

摘要翻译： 本发明涉及包含编码新的真菌氧化酶的基因及其核酸片段的新的分离的核酸序列。 它还涉及从曲霉菌分离和纯化的所述新的真菌氧化酶，其如SEQ ID NO 40或41所示的氨基酸序列及其功能等同物或衍生物。 本发明还涉及包含本发明的核酸分子的构建体，载体和宿主细胞以及本发明的氧化酶的制备方法。 本发明还涉及本发明的氧化酶在工业过程中的用途。