公开(公告)号：US20070010448A1

公开(公告)日：2007-01-11

申请号：US11519693

申请日：2006-09-12

申请人： Roland Contreras ,  Bart Nelissen ,  Marianne De Backer ,  Walter Luyten ,  Jasmine Viaene ,  Marc Logghe ,  Jorge Vialard

发明人： Roland Contreras ,  Bart Nelissen ,  Marianne De Backer ,  Walter Luyten ,  Jasmine Viaene ,  Marc Logghe ,  Jorge Vialard

IPC分类号： A61K38/16 ,  C07H21/04 ,  C12N15/74 ,  C12N1/18 ,  C07K14/40

CPC分类号： C07K14/40 ,  A61K38/00

摘要： The present invention is concerned with the identification of genes or functional fragments thereof from Candida albicans which are critical for growth and cell division and which genes may be used as selective drug targets to treat Candida albicans associated infections. Novel nucleic acid sequences from Candida albicans are also provided and which encode the polypeptides which are critical for growth of Candida albicans. Methods for the identification of anti-fungal compounds which inhibit fungal or yeast growth are also contemplated.

摘要翻译： 本发明涉及鉴定对于生长和细胞分裂至关重要的白色念珠菌的基因或其功能片段，哪些基因可用作治疗白色念珠菌相关感染的选择性药物靶标。 还提供了来自白色念珠菌的新型核酸序列，其编码对白色念珠菌生长至关重要的多肽。 还考虑了用于鉴定抑制真菌或酵母生长的抗真菌化合物的方法。

公开(公告)号：US20050148062A1

公开(公告)日：2005-07-07

申请号：US11057823

申请日：2005-02-14

申请人： Roland Contreras ,  Marianne De Backer ,  Walter Herman Luyten ,  Isabelle Karin Lenaerts ,  Bart Nelissen ,  Rieka Reekmans

发明人： Roland Contreras ,  Marianne De Backer ,  Walter Herman Luyten ,  Isabelle Karin Lenaerts ,  Bart Nelissen ,  Rieka Reekmans

IPC分类号： A01K67/027 ,  A61K31/7088 ,  A61K35/76 ,  A61K36/06 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/10 ,  A61P25/28 ,  A61P31/10 ,  A61P31/12 ,  A61P35/00 ,  A61P37/02 ,  A61P37/08 ,  A61P43/00 ,  C07K14/37 ,  C07K14/39 ,  C07K14/395 ,  C07K14/40 ,  C07K14/47 ,  C07K16/14 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/00 ,  C12N15/09 ,  C12N15/81 ,  C12Q1/02 ,  C12Q1/68 ,  C12R1/865 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  C12N1/18 ,  C07H21/04 ,  C12N1/16 ,  C12N15/74

CPC分类号： C07K14/39 ,  A61K2039/505 ,  A61K2039/53 ,  C07K14/37

摘要： The invention describes the use of the nucleic acid SEQ ID No 1 and polypeptide SEQ ID No 2 which are involved in a pathway eventually leading to programmed cell death of yeast or fungi for the preparation of a medicament for treating diseases associated with yeast or fungi or for the treatment of proliferative disorders or for preventing apoptosis in certain diseases. Methods are provided to identify compounds which selectively modulate the expression or functionality of said polypeptides in the same or a parallel pathway. Also provided are compounds as well as pharmaceutical compositions, medicaments and vaccines. The invention also comprises a new nucleic acid sequence, probes and primers derived thereof, expression vectors and host cells transformed with said vectors, polypeptides and antibodies raised against said polypeptides.

摘要翻译： 本发明描述了参与最终导致酵母或真菌的程序性细胞死亡的途径的核酸SEQ ID NO 1和多肽SEQ ID No 2的用途，用于制备用于治疗与酵母或真菌相关疾病的药物或 用于治疗某些疾病中的增殖性疾病或预防细胞凋亡。 提供方法来鉴定在相同或平行途径中选择性调节所述多肽的表达或功能的化合物。 还提供了化合物以及药物组合物，药物和疫苗。 本发明还包括新的核酸序列，其衍生的探针和引物，用所述载体转化的表达载体和宿主细胞，针对所述多肽产生的多肽和抗体。

公开(公告)号：US20060128021A1

公开(公告)日：2006-06-15

申请号：US11238031

申请日：2005-09-28

申请人： Russell Poulter ,  Walter Herman Luyten ,  Marianne De Backer ,  Bart Nelissen

发明人： Russell Poulter ,  Walter Herman Luyten ,  Marianne De Backer ,  Bart Nelissen

IPC分类号： C12N15/74 ,  C12N1/18

CPC分类号： C12N15/815 ,  C12N15/905 ,  C12N2800/90

摘要： TCa2 is a TyI/copia retrotransposon from the pathogenic yeast Candida albicans. In contrast to other retrotransposons it can appear as an abundant, extrachromosomal double-stranded DNA molecule, called pCal. The invention relates to the isolation and characterisation of TCa2 and pCal together with its uses for inducing random mutagenesis in a genome, as a component of a transposable element and of an expression vector.

摘要翻译： TCa2是来自致病酵母白色念珠菌的TyI / copia反转录转座子。 与其他反转录转座子相反，它可以表现为丰富的染色体外染色体双链DNA分子，称为pCal。 本发明涉及TCa2和pCal的分离和表征及其在基因组中诱导随机诱变的用途，作为转座元件和表达载体的组分。