公开(公告)号：US08925870B1

公开(公告)日：2015-01-06

申请号：US13417201

申请日：2012-03-09

Applicant: Jason Gordon ,  Carl Borgstrom ,  Noah Fisher ,  Cory Fuhrmeister ,  Nathan Madigan ,  Carly Parkins

Inventor： Jason Gordon ,  Carl Borgstrom ,  Noah Fisher ,  Cory Fuhrmeister ,  Nathan Madigan ,  Carly Parkins

IPC: B64C21/10

CPC classification number: B64C3/28 ,  B64C2003/445

Abstract: A wing may include a flexible leading edge skin segment having segment ends positioned adjacent to upper and lower leading edge wing skins to form a skin assembly. The upper leading edge wing skin may be positioned between the leading edge skin segment and an upper main wing skin. The lower leading edge wing skin may be positioned between the leading edge skin segment and a lower main wing skin. The wing may include a deployment device configured to flex the upper and lower leading edge wing skins thereby causing the leading edge skin segment to exhibit a rolling motion.

Abstract translation: 机翼可以包括柔性前缘皮肤段，其具有定位成邻近上和前前缘翼皮的段末端以形成皮肤组件。 上前缘翼皮可以位于前缘皮肤段和上主翼皮之间。 下部前缘翼皮可以位于前缘皮肤部分和下部主翼皮肤之间。 机翼可以包括构造成弯曲上和前引导翼翼表面的部署装置，从而使前缘皮肤段呈现滚动运动。

公开(公告)号：US08691991B2

公开(公告)日：2014-04-08

申请号：US10597902

申请日：2005-02-10

Applicant: Brian Alvin Johns ,  Eric Eugene Boros ,  Takshi Kawasuji ,  Cecilia S. Koble ,  Noriyuki Kurose ,  Hitoshi Murai ,  Ronald George Sherrill ,  Jason Gordon Weatherhead

Inventor： Brian Alvin Johns ,  Eric Eugene Boros ,  Takshi Kawasuji ,  Cecilia S. Koble ,  Noriyuki Kurose ,  Hitoshi Murai ,  Ronald George Sherrill ,  Jason Gordon Weatherhead

IPC: C07D471/04 ,  A61K31/4375

CPC classification number: C07D471/04

Abstract: The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

Abstract translation: 本发明的特征在于是HIV整合酶抑制剂的化合物，因此可用于抑制HIV复制，预防和/或治疗HIV感染以及治疗AIDS和/或ARC。

公开(公告)号：US08580967B2

公开(公告)日：2013-11-12

申请号：US13054847

申请日：2009-07-23

Applicant: Brian Alvin Johns ,  Jason Gordon Weatherhead ,  Toshikazu Hakogi ,  Yasunori Aoyama

Inventor： Brian Alvin Johns ,  Jason Gordon Weatherhead ,  Toshikazu Hakogi ,  Yasunori Aoyama

IPC: C07D213/79

CPC classification number: A61K31/675 ,  A61K31/4985 ,  A61K31/5377 ,  C07D211/86 ,  C07D309/40 ,  C07D498/14 ,  C07F9/65583

Abstract: The present invention features compounds that are prodrugs of HIV integrase inhibitors and therefore are useful in the delivery of compounds for the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC. For example, the present invention includes methyl 3-(benzyloxy)-1-(2,2-dihydroxyethyl)-4-oxo-1,4-dihydropyridine-2 -carboxylate of the formula P-8: and processes for the preparation thereof.

Abstract translation: 本发明的特征在于作为HIV整合酶抑制剂的前药的化合物，因此可用于递送用于抑制HIV复制，预防和/或治疗HIV感染以及治疗AIDS和/或ARC的化合物。 例如，本发明包括式P-8的3-（苄氧基）-1-（2,2-二羟乙基）-4-氧代-1,4-二氢吡啶-2-羧酸甲酯：及其制备方法 。

公开(公告)号：US20110183940A1

公开(公告)日：2011-07-28

申请号：US13054847

申请日：2009-07-23

Applicant: Brian Alvin Johns ,  Jason Gordon Weatherhead ,  Toshikazu Hakogi ,  Yasunori Aoyama

Inventor： Brian Alvin Johns ,  Jason Gordon Weatherhead ,  Toshikazu Hakogi ,  Yasunori Aoyama

IPC: A61K31/675 ,  C07D491/147 ,  A61K31/4985 ,  C07D413/14 ,  A61K31/5377 ,  C07D315/00 ,  C07D213/803 ,  A61P31/18

CPC classification number: A61K31/675 ,  A61K31/4985 ,  A61K31/5377 ,  C07D211/86 ,  C07D309/40 ,  C07D498/14 ,  C07F9/65583

Abstract: The present invention features compounds that are prodrugs of HIV integrase inhibitors and therefore are useful in the delivery of compounds for the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

Abstract translation: 本发明的特征在于作为HIV整合酶抑制剂的前药的化合物，因此可用于递送用于抑制HIV复制，预防和/或治疗HIV感染以及治疗AIDS和/或ARC的化合物。

公开(公告)号：US20110190236A1

公开(公告)日：2011-08-04

申请号：US13054633

申请日：2009-07-23

Applicant: Brian Alvin Johns ,  Jason Gordon Weatherhead ,  Toshikazu Hakogi ,  Yasunori Aoyama

Inventor： Brian Alvin Johns ,  Jason Gordon Weatherhead ,  Toshikazu Hakogi ,  Yasunori Aoyama

IPC: A61K31/675 ,  C07D498/14 ,  A61K31/5365 ,  A61P31/12 ,  A61P31/18

CPC classification number: A61K31/535 ,  C07D498/14

Abstract: The present invention features compounds that are prodrugs of HIIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

Abstract translation: 本发明的特征在于作为HIIV整合酶抑制剂的前药的化合物，因此可用于抑制HIV复制，预防和/或治疗HIV感染以及治疗AIDS和/或ARC。

公开(公告)号：US07988900B2

公开(公告)日：2011-08-02

申请号：US12576853

申请日：2009-10-09

Applicant: Jason Gordon Beith

Inventor： Jason Gordon Beith

IPC: B29C41/00

CPC classification number: A61F2/2415 ,  A61F2/2412

Abstract: There is provided an artificial cardiac or heart valve, more particularly a flexible leaflet heart valve used to replace natural aortic or pulmonary valves of the heart in which the leaflet geometry is defined by a parabolic function and a method of manufacturing said artificial cardiac valves. In addition, there is provided leaflets which have geometry defined by a parabolic function.

Abstract translation: 提供了一种人造心脏或心脏瓣膜，更具体地说，一种用于代替心脏的天然主动脉瓣或肺动脉瓣的柔性瓣膜心脏瓣膜，其中小叶几何形状由抛物线功能定义，以及制造所述人造心脏瓣膜的方法。 此外，还提供了具有由抛物线函数定义的几何形状的传​​单。

公开(公告)号：US20110124598A1

公开(公告)日：2011-05-26

申请号：US13055046

申请日：2009-07-23

Applicant: Brian Alvin Johns ,  Jason Gordon Weatherhead

Inventor： Brian Alvin Johns ,  Jason Gordon Weatherhead

IPC: A61K31/675 ,  C07D241/00 ,  C07D413/14 ,  A61K31/5377 ,  A61K31/4985 ,  A61P31/12 ,  A61P31/18

CPC classification number: C07D471/14

Abstract: The present invention features compounds that are prodrugs of HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.

Abstract translation: 本发明的特征在于作为HIV整合酶抑制剂的前药的化合物，因此可用于抑制HIV复制，预防和/或治疗HIV感染以及治疗AIDS和/或ARC。

公开(公告)号：US07682389B2

公开(公告)日：2010-03-23

申请号：US10524612

申请日：2004-03-22

Applicant: Jason Gordon Beith

Inventor： Jason Gordon Beith

IPC: A61F2/24

CPC classification number: A61F2/2415 ,  A61F2/2412

Abstract: There is provided an artificial cardiac or heart valve, more particularly a flexible leaflet heart valve used to replace natural aortic or pulmonary valves of the heart in which the leaflet geometry is defined by a parabolic function and a method of manufacturing said artificial cardiac valves. In addition, there is provided leaflets which have geometry defined by a parabolic function.

Abstract translation: 提供了一种人造心脏或心脏瓣膜，更具体地说，一种用于代替心脏的天然主动脉瓣或肺动脉瓣的柔性瓣膜心脏瓣膜，其中小叶几何形状由抛物线功能定义，以及制造所述人造心脏瓣膜的方法。 此外，还提供了具有由抛物线函数定义的几何形状的传​​单。

公开(公告)号：US20090092989A1

公开(公告)日：2009-04-09

申请号：US12246987

申请日：2008-10-07

Applicant: Hsueh-Chia Chang ,  Jason Gordon ,  Satyajyoti Senapati ,  Zachary Gagnon ,  Sagnik Basuray

Inventor： Hsueh-Chia Chang ,  Jason Gordon ,  Satyajyoti Senapati ,  Zachary Gagnon ,  Sagnik Basuray

IPC: C12Q1/68 ,  G01N27/26 ,  C12M1/00

CPC classification number: B03C5/005 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01L3/502761 ,  B03C5/026 ,  B03C2201/26 ,  C12Q1/6816 ,  G01N21/64 ,  C12Q2563/116 ,  C12Q2565/626 ,  C12Q2565/629

Abstract: Disclosed are example methods and devices for detecting one or more targets. An example method includes placing a sample including a first target with in a microfluidic device and hybridizing a plurality of copies of the first target with a plurality of nanostructures. The example method includes applying an electric current to the plurality of nanostructures and using an electric field created by the electric current to move the plurality of nanostructures. In addition, the plurality of nanostructures are sorted and evaluated to determine at least one of a presence, an absence, or a quantity of the first target.

Abstract translation: 公开了用于检测一个或多个目标的示例性方法和装置。 示例性方法包括将包含第一靶的样品放置在微流体装置中并将第一靶的多个拷贝与多个纳米结构杂交。 该示例性方法包括向多个纳米结构施加电流并且使用由电流产生的电场来移动多个纳米结构。 此外，对多个纳米结构进行分类和评估以确定第一靶的存在，不存在或数量中的至少一个。

公开(公告)号：US06935734B2

公开(公告)日：2005-08-30

申请号：US10453138

申请日：2003-06-03

Applicant: Benjamin A. Askren ,  Ronald W. Baker ,  Ligia Aura Bejat ,  Charles J. Cheek ,  Gerald L. Fish ,  Hrishikesh Pramod Gogate ,  Bhaskar Gopalanarayanan ,  Jason Gordon ,  Philip J. Heink ,  John W. Kietzman ,  Michael C. Leemhuis ,  Claudia A. Marin ,  Sean D. Smith ,  Donald W. Stafford

Inventor： Benjamin A. Askren ,  Ronald W. Baker ,  Ligia Aura Bejat ,  Charles J. Cheek ,  Gerald L. Fish ,  Hrishikesh Pramod Gogate ,  Bhaskar Gopalanarayanan ,  Jason Gordon ,  Philip J. Heink ,  John W. Kietzman ,  Michael C. Leemhuis ,  Claudia A. Marin ,  Sean D. Smith ,  Donald W. Stafford

IPC: B41J2/005 ,  B41J11/00 ,  B41J2/01

CPC classification number: B41J2/01 ,  B41J2/0057 ,  B41J11/0015

Abstract: An apparatus for ink-jet printing including an ink-jet print head to jet ink, a coating solid, and a coating holder to support the coating solid, wherein the coating holder transfers a portion of the coating solid onto a medium to form a coating solid layer. The coating holder and coating solid may be combined in a removable cartridge. In addition, the medium may be an intermediate transfer medium, a media support medium, a transfer medium, or media, such as paper. A method for inkjet printing also includes applying a coating solid to a medium to form a layer of the coating solid, in a solid form, having predetermined thickness, and applying ink to the medium. The layer of coating solid may interact with the applied ink to destabilize colorant in the ink.

Abstract translation: 一种用于喷墨印刷的设备，包括喷墨打印头以喷墨，涂层固体和涂层保持器以支撑涂层固体，其中涂层保持器将一部分涂层固体转移到介质上以形成涂层 固体层。 涂层保持器和涂层固体可以组合在可移除的盒中。 此外，介质可以是中间转印介质，介质载体介质，转印介质，或诸如纸的介质。 用于喷墨印刷的方法还包括将涂层固体施加到介质以形成具有预定厚度的固体形式的涂层固体层，并将油墨施加到介质上。 涂层固体层可与施加的油墨相互作用以使油墨中的着色剂失稳。