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公开(公告)号：US08524704B2
公开(公告)日：2013-09-03
申请号：US12535453
申请日：2009-08-04
申请人： Brett Busch , Brenton T. Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H. Wu
发明人： Brett Busch , Brenton T. Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H. Wu
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07D471/04 , C07D487/10 , C07D491/04
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
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公开(公告)号：US20110301128A1
公开(公告)日：2011-12-08
申请号：US13214665
申请日：2011-08-22
申请人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
发明人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
IPC分类号： A61K31/635 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/433 , A61K31/4025 , A61K31/4725 , A61K31/4709 , A61K31/506 , A61K31/428 , A61K31/40 , A61K31/519 , A61K31/5377 , A61K31/55 , A61P9/00 , A61P21/00 , A61P17/00 , A61P13/12 , A61P25/00 , A61P19/00 , A61P37/02 , A61P3/00 , A61P35/00 , A61P15/08 , A61P5/00 , A61K31/402
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US08026237B2
公开(公告)日：2011-09-27
申请号：US11572962
申请日：2005-07-30
申请人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
发明人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
IPC分类号： A61K31/40 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506 , C07D207/34 , C07D403/02 , C07D413/02
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US20100173824A1
公开(公告)日：2010-07-08
申请号：US12535453
申请日：2009-08-04
申请人： Brett Busch , Brenton T. Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H. Wu
发明人： Brett Busch , Brenton T. Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H. Wu
IPC分类号： A61K31/55 , C07D487/04 , C07D223/14 , C07D491/20 , A61K31/714 , A61K38/28 , A61K31/60 , A61P9/00 , A61P9/10
CPC分类号： C07D487/04 , C07D471/04 , C07D487/10 , C07D491/04
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地，提供了化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US07595311B2
公开(公告)日：2009-09-29
申请号：US10895431
申请日：2003-12-02
申请人： Brett Busch , Brenton T Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H Wu
发明人： Brett Busch , Brenton T Flatt , Xiao-Hui Gu , Richard Martin , Raju Mohan , Tie-Lin Wang , Jason H Wu
IPC分类号： A61P3/00 , A61K31/55 , C07D487/04
CPC分类号： C07D487/04 , C07D471/04 , C07D487/10 , C07D491/04
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地，提供了化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US20090203577A1
公开(公告)日：2009-08-13
申请号：US12096961
申请日：2006-12-12
申请人： Tae-Gon Baik , Chris A. Buhr , Brett B. Busch , Diva Sze-Ming Chan , Brenton T. Flatt , Xiao-Hui Gu , Vasu Jammalamadaka , Richard George Khoury , Katherine Lara , Sunghoon Ma , Richard Martin , Raju Mohan , John M. Nuss , Jason Jevious Parks , Jason H. Wu , Bryan K. S. Yeung , Wei Xu , Tie-Lin Wang , Longcheng Wang
发明人： Tae-Gon Baik , Chris A. Buhr , Brett B. Busch , Diva Sze-Ming Chan , Brenton T. Flatt , Xiao-Hui Gu , Vasu Jammalamadaka , Richard George Khoury , Katherine Lara , Sunghoon Ma , Richard Martin , Raju Mohan , John M. Nuss , Jason Jevious Parks , Jason H. Wu , Bryan K. S. Yeung , Wei Xu , Tie-Lin Wang , Longcheng Wang
IPC分类号： A61K31/55 , C07D487/04 , A61P3/00 , A61K38/22 , A61K38/28
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula I, which exhibit affinity for the farnesoid X receptor.
摘要翻译： 本发明涉及对法呢酯X受体表现出亲和性的式I化合物。
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公开(公告)号：US20080234270A1
公开(公告)日：2008-09-25
申请号：US11572962
申请日：2005-07-30
申请人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
发明人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
IPC分类号： A61K31/40 , C07D207/34 , C07D403/02 , C07D413/02 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US08367667B2
公开(公告)日：2013-02-05
申请号：US13214665
申请日：2011-08-22
申请人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
发明人： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
IPC分类号： A61K31/40 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506
CPC分类号： C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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