公开(公告)号：US20070225377A1

公开(公告)日：2007-09-27

申请号：US10576228

申请日：2004-10-13

申请人： Brenton Flatt ,  Richard Martin ,  Raju Mohan ,  Brett Murphy

发明人： Brenton Flatt ,  Richard Martin ,  Raju Mohan ,  Brett Murphy

IPC分类号： A61K31/075 ,  A61K31/10 ,  A61K31/122 ,  C07C39/00 ,  C07C43/23

CPC分类号： C07C37/16 ,  C07C37/20 ,  C07C39/16 ,  C07C39/21 ,  C07C39/367 ,  C07C43/23 ,  C07D211/22

摘要： The present invention is directed to 1α,25-dihydroxyvitamin D3 mimics which modulate the vitamin D receptor (VDR). The invention is further directed to pharmaceutical compositions and methods for the treatment, prevention or amelioration of one or more symptoms of disease or disorder related to the activity of the vitamin D receptor using an effective amount of a compound of formula (I).

摘要翻译： 本发明涉及调节维生素D受体（VDR）的1α，25-二羟基维生素D 3模拟物。 本发明进一步涉及使用有效量的式（I）化合物治疗，预防或改善与维生素D受体活性相关的疾病或病症的一种或多种症状的药物组合物和方法。

公开(公告)号：US08507292B2

公开(公告)日：2013-08-13

申请号：US13175699

申请日：2011-07-01

申请人： Kannan Srinivasan ,  Bruce Richter ,  Christopher A. Pohl ,  Brett Murphy ,  Brian Dorich ,  S. M. Rahmat Ullah

发明人： Kannan Srinivasan ,  Bruce Richter ,  Christopher A. Pohl ,  Brett Murphy ,  Brian Dorich ,  S. M. Rahmat Ullah

IPC分类号： G01N1/18

CPC分类号： G01N1/34 ,  B01D11/0492 ,  B01J20/043 ,  B01J20/10 ,  B01J20/14 ,  B01J20/26 ,  B01J20/3236 ,  B01J2220/46 ,  B01J2220/66 ,  G01N1/4022 ,  G01N1/4044 ,  G01N1/405 ,  G01N30/7206 ,  G01N30/96 ,  G01N2001/4061 ,  Y10T436/10 ,  Y10T436/255

摘要： A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface.

公开(公告)号：US20110301128A1

公开(公告)日：2011-12-08

申请号：US13214665

申请日：2011-08-22

申请人： Lynne Canne Bannen ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Brenton T. Flatt ,  Timothy Patrick Forsyth ,  Xiao-Hui Gu ,  Morrison B. Mac ,  Larry W. Mann ,  Grace Mann ,  Richard Martin ,  Raju Mohan ,  Brett Murphy ,  Michael Charles Nyman ,  William C. Stevens ,  Tie-Lin Wang ,  Yong Wang ,  Jason H. Wu

发明人： Lynne Canne Bannen ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Brenton T. Flatt ,  Timothy Patrick Forsyth ,  Xiao-Hui Gu ,  Morrison B. Mac ,  Larry W. Mann ,  Grace Mann ,  Richard Martin ,  Raju Mohan ,  Brett Murphy ,  Michael Charles Nyman ,  William C. Stevens ,  Tie-Lin Wang ,  Yong Wang ,  Jason H. Wu

IPC分类号： A61K31/635 ,  A61K31/4155 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/433 ,  A61K31/4025 ,  A61K31/4725 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/428 ,  A61K31/40 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61P9/00 ,  A61P21/00 ,  A61P17/00 ,  A61P13/12 ,  A61P25/00 ,  A61P19/00 ,  A61P37/02 ,  A61P3/00 ,  A61P35/00 ,  A61P15/08 ,  A61P5/00 ,  A61K31/402

CPC分类号： C07D207/416 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.

摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。

公开(公告)号：US08026237B2

公开(公告)日：2011-09-27

申请号：US11572962

申请日：2005-07-30

申请人： Lynne Canne Bannen ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Brenton T Flatt ,  Timothy Patrick Forsyth ,  Xiao-Hui Gu ,  Morrison B Mac ,  Larry W Mann ,  Grace Mann ,  Richard Martin ,  Raju Mohan ,  Brett Murphy ,  Michael Charles Nyman ,  William C Stevens ,  Tie-Lin Wang ,  Yong Wang ,  Jason H Wu

发明人： Lynne Canne Bannen ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Brenton T Flatt ,  Timothy Patrick Forsyth ,  Xiao-Hui Gu ,  Morrison B Mac ,  Larry W Mann ,  Grace Mann ,  Richard Martin ,  Raju Mohan ,  Brett Murphy ,  Michael Charles Nyman ,  William C Stevens ,  Tie-Lin Wang ,  Yong Wang ,  Jason H Wu

IPC分类号： A61K31/40 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/506 ,  C07D207/34 ,  C07D403/02 ,  C07D413/02

CPC分类号： C07D207/416 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.

摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。

公开(公告)号：US20130316466A1

公开(公告)日：2013-11-28

申请号：US13958810

申请日：2013-08-05

申请人： Kannan SRINIVASAN ,  Bruce RICHTER ,  Christopher A. POHL ,  Brett MURPHY ,  Brian DORICH ,  SM Rahmat ULLAH

发明人： Kannan SRINIVASAN ,  Bruce RICHTER ,  Christopher A. POHL ,  Brett MURPHY ,  Brian DORICH ,  SM Rahmat ULLAH

IPC分类号： G01N1/34

CPC分类号： G01N1/34 ,  B01D11/0492 ,  B01J20/043 ,  B01J20/10 ,  B01J20/14 ,  B01J20/26 ,  B01J20/3236 ,  B01J2220/46 ,  B01J2220/66 ,  G01N1/4022 ,  G01N1/4044 ,  G01N1/405 ,  G01N30/7206 ,  G01N30/96 ,  G01N2001/4061 ,  Y10T436/10 ,  Y10T436/255

摘要： A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface.

公开(公告)号：US20120028368A1

公开(公告)日：2012-02-02

申请号：US13175699

申请日：2011-07-01

申请人： Kannan Srinivasan ,  Bruce Richter ,  Christopher A. Pohl ,  Brett Murphy ,  Brian Dorich ,  S.M. Rahmat Ullah

发明人： Kannan Srinivasan ,  Bruce Richter ,  Christopher A. Pohl ,  Brett Murphy ,  Brian Dorich ,  S.M. Rahmat Ullah

IPC分类号： G01N1/28

CPC分类号： G01N1/34 ,  B01D11/0492 ,  B01J20/043 ,  B01J20/10 ,  B01J20/14 ,  B01J20/26 ,  B01J20/3236 ,  B01J2220/46 ,  B01J2220/66 ,  G01N1/4022 ,  G01N1/4044 ,  G01N1/405 ,  G01N30/7206 ,  G01N30/96 ,  G01N2001/4061 ,  Y10T436/10 ,  Y10T436/255

摘要： A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface.

摘要翻译： 一种通过在固体吸附剂材料中吸附含水液体样品（包括有机分析物和酸或碱）来预处理和提取液体样品的方法，并且通过与保留在固体吸附剂上的中和离子反应而至少部分地中和酸或碱 在高温和高压下使液体样品吸附的吸附剂材料与有机溶剂接触以将分析物提取到所述溶剂中，优选在具有带有锆金属内表面的萃取室的容器中。

公开(公告)号：US07863298B2

公开(公告)日：2011-01-04

申请号：US10576228

申请日：2004-10-13

申请人： Brenton T. Flatt ,  Richard Martin ,  Raju Mohan ,  Brett Murphy

发明人： Brenton T. Flatt ,  Richard Martin ,  Raju Mohan ,  Brett Murphy

IPC分类号： A61K31/451 ,  C07D211/14

CPC分类号： C07C37/16 ,  C07C37/20 ,  C07C39/16 ,  C07C39/21 ,  C07C39/367 ,  C07C43/23 ,  C07D211/22

摘要： The present invention is directed to 1α,25-dihydroxyvitamin D3 mimics which modulate the vitamin D receptor (VDR). The invention is further directed to pharmaceutical compositions and methods for the treatment, prevention or amelioration of one or more symptoms of disease or disorder related to the activity of the vitamin D receptor using an effective amount of a compound of formula (I).

摘要翻译： 本发明涉及调节维生素D受体（VDR）的1α，25-二羟基维生素D3模拟物。 本发明进一步涉及使用有效量的式（I）化合物治疗，预防或改善与维生素D受体活性相关的疾病或病症的一种或多种症状的药物组合物和方法。

公开(公告)号：US20090221079A1

公开(公告)日：2009-09-03

申请号：US12039687

申请日：2008-02-28

申请人： Kannan Srinivasan ,  Bruce Richter ,  Christopher A. Pohl ,  Brett Murphy ,  Brian Dorich ,  S.M. Rahmat Ullah

发明人： Kannan Srinivasan ,  Bruce Richter ,  Christopher A. Pohl ,  Brett Murphy ,  Brian Dorich ,  S.M. Rahmat Ullah

IPC分类号： G01N31/00 ,  B01J19/00

CPC分类号： G01N1/34 ,  B01D11/0492 ,  B01J20/043 ,  B01J20/10 ,  B01J20/14 ,  B01J20/26 ,  B01J20/3236 ,  B01J2220/46 ,  B01J2220/66 ,  G01N1/4022 ,  G01N1/4044 ,  G01N1/405 ,  G01N30/7206 ,  G01N30/96 ,  G01N2001/4061 ,  Y10T436/10 ,  Y10T436/255

摘要： A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface.

摘要翻译： 一种通过在固体吸附剂材料中吸附含水液体样品（包括有机分析物和酸或碱）来预处理和提取液体样品的方法，并且通过与保留在固体吸附剂上的中和离子反应而至少部分地中和酸或碱 在高温和高压下使液体样品吸附的吸附剂材料与有机溶剂接触以将分析物提取到所述溶剂中，优选在具有带有锆金属内表面的萃取室的容器中。

公开(公告)号：US20080234270A1

公开(公告)日：2008-09-25

申请号：US11572962

申请日：2005-07-30

申请人： Lynne Canne Bannen ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Brenton T. Flatt ,  Timothy Patrick Forsyth ,  Xiao-Hui Gu ,  Morrison B. Mac ,  Larry W. Mann ,  Grace Mann ,  Richard Martin ,  Raju Mohan ,  Brett Murphy ,  Michael Charles Nyman ,  William C. Stevens ,  Tie-Lin Wang ,  Yong Wang ,  Jason H. Wu

发明人： Lynne Canne Bannen ,  Jeff Chen ,  Lisa Esther Dalrymple ,  Brenton T. Flatt ,  Timothy Patrick Forsyth ,  Xiao-Hui Gu ,  Morrison B. Mac ,  Larry W. Mann ,  Grace Mann ,  Richard Martin ,  Raju Mohan ,  Brett Murphy ,  Michael Charles Nyman ,  William C. Stevens ,  Tie-Lin Wang ,  Yong Wang ,  Jason H. Wu

IPC分类号： A61K31/40 ,  C07D207/34 ,  C07D403/02 ,  C07D413/02 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/506

CPC分类号： C07D207/416 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12

摘要： Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.

摘要翻译： 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。

公开(公告)号：US20180295900A1

公开(公告)日：2018-10-18

申请号：US15951265

申请日：2018-04-12

申请人： Brett Murphy

发明人： Brett Murphy

IPC分类号： A41D13/00 ,  A41D1/08 ,  A41D11/00

摘要： Athletic garments comprising interchangeable top portions and bottom portions. The bottom portions may include an integrated or removable panty bottom portion to accommodate diapers, training pants, or other undergarments typically worn by young children. The athletic garments may be in a variety of style and colors and may be reversible for increased variety.