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公开(公告)号：US08222263B2
公开(公告)日：2012-07-17
申请号：US12049225
申请日：2008-03-14
Applicant: Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
Inventor： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
IPC: A61K31/517 , A01N43/54
CPC classification number: C07D239/42 , C07D239/70 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/12
Abstract: The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.
Abstract translation: 本发明涉及式I化合物或其单一异构体; 其中除了制备式I化合物的方法之外，化合物任选为其药学上可接受的盐，水合物，溶剂合物或其组合，以及使用式I化合物治疗癌症的方法。
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公开(公告)号：US07989622B2
公开(公告)日：2011-08-02
申请号：US11988862
申请日：2006-10-09
Applicant: William Bajjalieh , Lynne Canne Bannen , S. David Brown , Patrick Kearney , Morrison B. Mac , Charles K. Marlowe , John M. Nuss , Zerom Tesfai , Yong Wang , Wei Xu
Inventor： William Bajjalieh , Lynne Canne Bannen , S. David Brown , Patrick Kearney , Morrison B. Mac , Charles K. Marlowe , John M. Nuss , Zerom Tesfai , Yong Wang , Wei Xu
IPC: A61K31/4985 , A61K31/498 , C07D241/36 , C07D403/14 , C07D471/04 , A61P35/02 , A61P35/00
CPC classification number: C07D401/12 , C07D241/44 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , Y02P20/55
Abstract: The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases.
Abstract translation: 本发明包括与许多恶性肿瘤如卵巢癌，宫颈癌，乳腺癌，结肠癌，直肠癌和成胶质细胞瘤等相关的磷脂酰肌醇3-激酶（PI3K）的小分子抑制剂。 因此，本发明的化合物可用于治疗，预防和/或抑制这些疾病。
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公开(公告)号：US20100305093A1
公开(公告)日：2010-12-02
申请号：US12756374
申请日：2010-04-08
Applicant: Neel Kumar Anand , Arlyn Arcalas , Charles M. Blazey , Chris A. Buhr , Jonah Cannoy , Sergey Ephsteyn , Henry William Beecroft Johnson , Anagha Joshi , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Sunghoon Ma , Morrison B. Mac , John M. Nuss , Craig Stacy Takeuchi , Longcheng Wang , Yong Wang
Inventor： Neel Kumar Anand , Arlyn Arcalas , Charles M. Blazey , Chris A. Buhr , Jonah Cannoy , Sergey Ephsteyn , Henry William Beecroft Johnson , Anagha Joshi , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Sunghoon Ma , Morrison B. Mac , John M. Nuss , Craig Stacy Takeuchi , Longcheng Wang , Yong Wang
IPC: A61K31/553 , C07D405/10 , A61P35/00 , A61P37/00 , A61P35/02 , A61P27/00
CPC classification number: C07D267/14 , C07D413/04
Abstract: The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.
Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐或溶剂合物，以及制备和使用该化合物的方法。
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公开(公告)号：US20100105953A1
公开(公告)日：2010-04-29
申请号：US12605118
申请日：2009-10-23
Applicant: Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
Inventor： Lynne Canne Bannen , Erick W. Co , Vasu Jammalamadaka , John M. Nuss , Moon Hwan Kim , Donna Tra Le , Amy Lew , Morrison B. Mac , Shumeye Mamo , Zhaoyang Wen , Wei Xu , Richard George Khoury
IPC: C07C315/00
CPC classification number: C07D241/04 , C07C309/87 , C07D213/70 , C07D401/06 , C07D401/12 , C07D403/06 , C07D413/06
Abstract: The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
Abstract translation: 本发明提供了用于抑制ADAM-10蛋白质的化合物，具有选择性对MMP-1。 这些化合物可用于体外研究ADAM-10（及其抑制）在生物过程中的作用。 本发明还包括药物组合物，其包含一种或多种本发明的ADAM-10抑制剂与药学上可接受的载体的组合。 这样的组合物可用于治疗癌症，关节炎和与血管发生相关的疾病。 相应地，本发明还包括治疗癌症，关节炎和与血管生成有关的疾病形式的方法，其中ADAM-10起关键作用。
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公开(公告)号：US20100087440A1
公开(公告)日：2010-04-08
申请号：US11988862
申请日：2006-10-09
Applicant: William Bajjalieh , Lynne Canne Bannen , S. David Brown , Patrick Kearney , Morrison B. Mac , Charles K. Marlowe , John M. Nuss , Zerom Tesfai , Yong Wang , Wei Xu
Inventor： William Bajjalieh , Lynne Canne Bannen , S. David Brown , Patrick Kearney , Morrison B. Mac , Charles K. Marlowe , John M. Nuss , Zerom Tesfai , Yong Wang , Wei Xu
IPC: A61K31/4985 , C07D241/36 , C07D403/14 , C07D471/04 , A61K31/498 , A61P35/02 , A61P35/00
CPC classification number: C07D401/12 , C07D241/44 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , Y02P20/55
Abstract: The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and glioblastomas, among others. Accordingly, the compounds of the present invention are useful for treating, preventing, and/or inhibiting these diseases.
Abstract translation: 本发明包括与许多恶性肿瘤如卵巢癌，宫颈癌，乳腺癌，结肠癌，直肠癌和成胶质细胞瘤等相关的磷脂酰肌醇3-激酶（PI3K）的小分子抑制剂。 因此，本发明的化合物可用于治疗，预防和/或抑制这些疾病。
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Patent Agency Ranking
公开(公告)号：US20080234270A1
公开(公告)日：2008-09-25
申请号：US11572962
申请日：2005-07-30
Applicant: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
Inventor： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
IPC: A61K31/40 , C07D207/34 , C07D403/02 , C07D413/02 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506
CPC classification number: C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
Abstract translation: 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US08754092B2
公开(公告)日：2014-06-17
申请号：US13487594
申请日：2012-06-04
Applicant: Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
Inventor： Suleyman Bahceci , William Bajjalieh , Jeff Chen , Sergey Epshteyn , Timothy Patrick Forsyth , Tai Phat Huynh , Byung Gyu Kim , James W. Leahy , Matthew Sangyup Lee , Gary L. Lewis , Morrison B. Mac , Grace Mann , Charles K. Marlowe , Brian Hugh Ridgway , Joan C. Sangalang , Xian Shi , Craig Stacy Takeuchi , Yong Wang
IPC: A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC classification number: C07D239/42 , C07D239/70 , C07D239/84 , C07D239/95 , C07D401/04 , C07D403/12
Abstract: The present invention is directed to a compound of Formula I or a single isomer thereof; where the compound is optionally as a pharmaceutically acceptable salt, hydrate, solvate or combination thereof, in addition to methods of preparing a Compound of Formula I, and methods of using a Compound of Formula I to treat cancer.
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公开(公告)号：US20120184523A1
公开(公告)日：2012-07-19
申请号：US13427093
申请日：2012-03-22
Applicant: Lynne Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrison B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takbuchi , Yong Wang , Wei Xu
Inventor： Lynne Canne Bannen , Diva Sze-Ming Chan , Jeff Chen , Lisa Esther Dalrymple , Timothy Patrick Forsyth , Tai Phat Huynh , Vasu Jammalamadaka , Richard George Khoury , James William Leahy , Morrison B. Mac , Grace Mann , Larry W. Mann , John M. Nuss , Jason Jevious Parks , Craig Stacy Takbuchi , Yong Wang , Wei Xu
IPC: A61K31/4709 , A61K31/517 , C07D215/233 , C07D401/12 , A61K31/47 , C07D239/94 , C07D417/12 , C07D401/10 , C07D413/12 , A61K31/5377 , C07D215/46 , C07D417/14 , A61K31/501 , A61K31/496 , A61K31/513 , C12N9/99 , C12Q1/48 , C12Q1/66 , A61P35/00 , A61P29/00 , A61P37/00 , A61P37/06 , A61P25/00 , A61P17/06 , A61P9/00 , A61P9/10 , A61P1/00 , A61P19/02 , A61P27/02 , C07D403/10
CPC classification number: C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
Abstract: The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
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公开(公告)号：US20110301128A1
公开(公告)日：2011-12-08
申请号：US13214665
申请日：2011-08-22
Applicant: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
Inventor： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T. Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B. Mac , Larry W. Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C. Stevens , Tie-Lin Wang , Yong Wang , Jason H. Wu
IPC: A61K31/635 , A61K31/4155 , A61K31/4439 , A61K31/454 , A61K31/433 , A61K31/4025 , A61K31/4725 , A61K31/4709 , A61K31/506 , A61K31/428 , A61K31/40 , A61K31/519 , A61K31/5377 , A61K31/55 , A61P9/00 , A61P21/00 , A61P17/00 , A61P13/12 , A61P25/00 , A61P19/00 , A61P37/02 , A61P3/00 , A61P35/00 , A61P15/08 , A61P5/00 , A61K31/402
CPC classification number: C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
Abstract translation: 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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公开(公告)号：US08026237B2
公开(公告)日：2011-09-27
申请号：US11572962
申请日：2005-07-30
Applicant: Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
Inventor： Lynne Canne Bannen , Jeff Chen , Lisa Esther Dalrymple , Brenton T Flatt , Timothy Patrick Forsyth , Xiao-Hui Gu , Morrison B Mac , Larry W Mann , Grace Mann , Richard Martin , Raju Mohan , Brett Murphy , Michael Charles Nyman , William C Stevens , Tie-Lin Wang , Yong Wang , Jason H Wu
IPC: A61K31/40 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/506 , C07D207/34 , C07D403/02 , C07D413/02
CPC classification number: C07D207/416 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
Abstract: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors.
Abstract translation: 提供了调节受体活性的化合物，组合物和方法。 特别地提供化合物和组合物用于调节受体的活性和用于治疗，预防或改善与受体活性直接或间接相关的疾病或病症的一种或多种症状。
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