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1.发明授权Methods and apparatus for pulsatile release of medicaments from a punctal plug 有权用于从泪点塞中脉动释放药物的方法和装置公开(公告)号：US08808257B2
公开(公告)日：2014-08-19
申请号：US12857885
申请日：2010-08-17
CPC分类号： A61F9/0026 , A61F9/00772 , A61K9/0019 , A61K9/0021 , A61K9/0051 , A61K9/5031 , A61M31/00
摘要： This invention discloses methods and apparatus for providing pulsatile release of active agents via a punctal plug inserted into a punctum. A tube is provided which may be inserted into a cavity of a punctal plug. One or more pulsatile delivery units are arranged in a generally linear fashion within the tube. The pulsatile delivery units include a core comprising the active agent and an encapsulation layer around the core.
摘要翻译： 本发明公开了通过插入泪点的泪点塞提供活性剂脉动释放的方法和装置。 提供了可以插入泪点塞的空腔中的管。 一个或多个脉冲输送单元在管内以大致线性的方式排列。 脉动递送单元包括包含活性剂的芯和围绕芯的包封层。
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公开(公告)号：US08808256B2
公开(公告)日：2014-08-19
申请号：US13350963
申请日：2012-01-16
申请人： Stephen R. Beaton , Michael Ferran , Justin Scott Jacobs , Jason M. Tokarski , Christopher S. Gudeman , Fardad Chamran , Paul J. Rubel , Bret A. Coldren
发明人： Stephen R. Beaton , Michael Ferran , Justin Scott Jacobs , Jason M. Tokarski , Christopher S. Gudeman , Fardad Chamran , Paul J. Rubel , Bret A. Coldren
CPC分类号： A61F9/0017 , A61F9/00772
摘要： A punctal plug or lacrimal insert comprising a microelectromechanical system pump and associated reservoir may be utilized to deliver precise dosages of an active agent into the eye though the tear film. The microelectromechanical system pump comprises four main components; namely, a reservoir, a pump, a series of valves and a vent. The microelectromechanical system pump is positioned within a cavity in the punctal plug. The microelectromechanical system pump is positioned with a cavity in the punctal plug.
摘要翻译： 包括微机电系统泵和相关贮存器的泪点塞或泪液插入物可用于通过泪膜将精确剂量的活性剂递送到眼睛中。 微机电系统泵包括四个主要部件; 即储存器，泵，一系列阀和通风口。 微机电系统泵定位在泪点塞中的腔内。 微机电系统泵定位在泪点塞中有空腔。
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公开(公告)号：US20130184661A1
公开(公告)日：2013-07-18
申请号：US13350963
申请日：2012-01-16
申请人： Stephen R. Beaton , Michael Ferran , Justin Scott Jacobs , Jason M. Tokarski , Christopher S. Gudeman , Fardad Chamran , Paul J. Rubel , Bret A. Coldren
发明人： Stephen R. Beaton , Michael Ferran , Justin Scott Jacobs , Jason M. Tokarski , Christopher S. Gudeman , Fardad Chamran , Paul J. Rubel , Bret A. Coldren
CPC分类号： A61F9/0017 , A61F9/00772
摘要： A punctal plug or lacrimal insert comprising a microelectromechanical system pump and associated reservoir may be utilized to deliver precise dosages of an active agent into the eye though the tear film. The microelectromechanical system pump comprises four main components; namely, a reservoir, a pump, a series of valves and a vent. The microelectromechanical system pump is positioned within a cavity in the punctal plug. The microelectromechanical system pump is positioned with a cavity in the punctal plug.
摘要翻译： 包括微机电系统泵和相关贮存器的泪点塞或泪液插入物可用于通过泪膜将精确剂量的活性剂递送到眼睛中。 微机电系统泵包括四个主要部件; 即储存器，泵，一系列阀和通风口。 微机电系统泵定位在泪点塞中的腔内。 微机电系统泵定位在泪点塞中有空腔。
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公开(公告)号：US20080246171A1
公开(公告)日：2008-10-09
申请号：US11843405
申请日：2007-08-22
申请人： Gregory L. Berckmiller , Vincent H. Barre , Timothy P. Freeman , Scott F. Ansell , Changhong Yin , Jason M. Tokarski
发明人： Gregory L. Berckmiller , Vincent H. Barre , Timothy P. Freeman , Scott F. Ansell , Changhong Yin , Jason M. Tokarski
IPC分类号： B29D11/00
CPC分类号： B29D11/00125 , B29C35/16 , B29C45/73 , B29C45/7337 , B29C2035/1616 , B29D11/00038 , B29D11/0048 , B29D11/023
摘要： The present invention includes molds for forming ophthalmic lenses, such as contact lens. In particular, the present invention relates to apparatus, molds and methods for fashioning mold parts used to fashion an ophthalmic lens which includes cooling a mold structure used to fashion a mold part prior to depositing a molten material into the mold structure.
摘要翻译： 本发明包括用于形成眼镜片的模具，例如隐形眼镜。 特别地，本发明涉及用于制造用于制造眼镜片的模具部件的装置，模具和方法，其包括在将熔融材料沉积到模具结构中之前冷却用于制造模具部件的模具结构。
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公开(公告)号：US20120157938A1
公开(公告)日：2012-06-21
申请号：US13246420
申请日：2011-09-27
申请人： Jason M. Tokarski , Victor Lust , Chris Lyons , Jeffrey Miller , Phillip Parnell, SR. , Günter Solms
发明人： Jason M. Tokarski , Victor Lust , Chris Lyons , Jeffrey Miller , Phillip Parnell, SR. , Günter Solms
IPC分类号： A61F9/00
CPC分类号： A61F9/00772 , A61F9/0017 , A61F2220/0025
摘要： Disclosed are lacrimal inserts and their method of use for delivery of of medication to the eye. The plug includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The plug may contain a core, or reservoir, at least partially within the body portion comprising a therapeutic agent that is configured to controlled release into the eye and is configured to release medication via a designated port, valve, or orifice in the insert housing and inhibits diffusion of medication via the housing itself The core may include retention features to ensure that it remains securely located within the lacrimal insert over its usable life.
摘要翻译： 公开了泪液插入物及其用于向眼睛递送药物的方法。 塞子包括尺寸适于穿过泪点并被定位在眼睑的泪小管内的体部。 塞子可以包含至少部分地在主体部分内的芯部或储存器，其包括被配置为控制释放到眼睛中并被配置为经由插入物外壳中的指定端口，阀或孔释放药物的治疗剂，以及 阻止药物通过外壳本身的扩散。芯可以包括留置特征，以确保其在其使用寿命内保持牢固地位于泪液插入物内。
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6.发明申请Methods and apparatus for pulsatile release of medicaments from a punctal plug 有权用于从泪点塞中脉动释放药物的方法和装置公开(公告)号：US20110054418A1
公开(公告)日：2011-03-03
申请号：US12857885
申请日：2010-08-17
CPC分类号： A61F9/0026 , A61F9/00772 , A61K9/0019 , A61K9/0021 , A61K9/0051 , A61K9/5031 , A61M31/00
摘要： This invention discloses methods and apparatus for providing pulsatile release of active agents via a punctal plug inserted into a punctum. A tube is provided which may be inserted into a cavity of a punctal plug. One or more pulsatile delivery units are arranged in a generally linear fashion within the tube. The pulsatile delivery units include a core comprising the active agent and an encapsulation layer around the core.
摘要翻译： 本发明公开了通过插入泪点的泪点塞提供活性剂脉动释放的方法和装置。 提供了可以插入泪点塞的空腔中的管。 一个或多个脉冲输送单元在管内以大致线性的方式排列。 脉动递送单元包括包含活性剂的芯和围绕芯的包封层。
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公开(公告)号：US20100243100A1
公开(公告)日：2010-09-30
申请号：US12414815
申请日：2009-03-31
申请人： Jason M. Tokarski , Michael J. Trezza, II , Aruna Nathan , Hassan Chaouk , Ken Church , Phillip King Parnell, SR.
发明人： Jason M. Tokarski , Michael J. Trezza, II , Aruna Nathan , Hassan Chaouk , Ken Church , Phillip King Parnell, SR.
IPC分类号： B65B3/12
CPC分类号： A61K9/0051 , A61F9/00772 , A61J3/00 , B65B3/003
摘要： This invention discloses methods and apparatus for providing a dispensing a material with an active agent into an ophthalmic device. Some embodiments include dispensing high viscous materials into a punctal plug.
摘要翻译： 本发明公开了一种提供将活性剂分配到眼科装置中的方法和装置。 一些实施例包括将高粘性材料分配到泪点塞中。
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