公开(公告)号：US20090053237A1

公开(公告)日：2009-02-26

申请号：US11915055

申请日：2006-05-22

申请人： Maria Leticia Zarantonelli ,  Aude Antignac ,  Jean-Michel Alonso ,  Muhamed-Kheir Taha ,  Faridabano Nato

发明人： Maria Leticia Zarantonelli ,  Aude Antignac ,  Jean-Michel Alonso ,  Muhamed-Kheir Taha ,  Faridabano Nato

IPC分类号： A61K39/395 ,  C07K14/00 ,  C07H21/00 ,  C07K16/00 ,  A61P31/04 ,  A61P37/04 ,  G01N33/53 ,  A61K38/16 ,  A61K39/095

CPC分类号： A61K39/095 ,  A61K2039/505 ,  C07K14/22 ,  C07K16/1217

摘要： The present invention is drawn to a penicillin-binding protein expressed by Neisseria meningitidis, or a fragment, or a variant, or a variant fragment thereof, or nucleic acids encoding them, or antibodies or antibody fragments directed against them, as medicaments or in pharmaceutical compositions. The invention is also directed to the use of penicillin-binding proteins expressed by Neisseria meningitidis, or nucleic acids encoding them, or antibodies directed against them for the prophylactic and/or therapeutic immunotherapy of mammals, preferably human beings, against infection by Neisseria meningitidis and/or by a bacterial strain expressing a variant of a Neisseria meningitidis penicillin-binding protein.

摘要翻译： 本发明涉及由脑膜炎奈瑟氏球菌或其片段，变体或其变体片段或编码它们的核酸，或针对它们的抗体或抗体片段作为药物或药物中表达的青霉素结合蛋白 组合物。 本发明还涉及脑膜炎奈瑟菌脑膜炎奈瑟氏球菌表达的青霉素结合蛋白或编码它们的核酸，或针对它们的抗体用于预防和/或治疗哺乳动物，优选人类免疫治疗，用于脑膜炎奈瑟氏球菌感染和 /或通过表达脑膜炎奈瑟氏球菌青霉素结合蛋白的变体的细菌菌株。