Artemisinine derivatives, and uses thereof for treating malaria
    8.
    发明授权
    Artemisinine derivatives, and uses thereof for treating malaria 有权
    青蒿素衍生物及其用于治疗疟疾的用途

    公开(公告)号:US07417155B2

    公开(公告)日:2008-08-26

    申请号:US10493576

    申请日:2002-10-25

    IPC分类号: C07D493/18

    CPC分类号: C07D493/20

    摘要: A new artemisinin derivatives, of following general formula (I): In which: a and b represent a single or a double bond, n1 and n2 represent 0 or 1, R1 represents a fluoroalkyl group or a fluoroaryl group, R2 represents a hydrogen atom, or a halogen atom, or a group, if appropriate ionisable, making it possible to render said compounds of formula (I) water-soluble, R3 represents a group, if appropriate ionisable, making it possible to render said compounds of formula (I) water-soluble, R4 represents H or OH. The invention also relates to the process by which they are obtained, and their uses in pharmaceutical compositions intended for the treatment of malaria.

    摘要翻译: 一种新的青蒿素衍生物,其具有以下通式(I):其中:a和b表示单键或双键,n1和n2表示0或1,R 1表示氟代烷基或 氟代芳基,R 2表示氢原子或卤素原子或基团,如果合适的话可以电离,使得可以使所述式(I)化合物具有水溶性, 3 代表一个基团,如果合适的话可以电离,使得可以使所述式(I)化合物是水溶性的,R 4代表H或OH。 本发明还涉及获得它们的方法及其在旨在治疗疟疾的药物组合物中的用途。