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    Bioactive depside and anthocyanin compounds, compositions, and methods of use
    2.
    发明授权
    Bioactive depside and anthocyanin compounds, compositions, and methods of use 有权
    生物活性底物和花青素化合物，组合物和使用方法

    公开(公告)号：US08846757B2

    公开(公告)日：2014-09-30

    申请号：US12309804

    申请日：2007-07-31

    申请人： Jeanine D'Armiento ,  Kurt Reynertson ,  Edward Kennelly ,  Alison Wallace

    发明人： Jeanine D'Armiento ,  Kurt Reynertson ,  Edward Kennelly ,  Alison Wallace

    IPC分类号： A61K31/235 ,  A23L1/30 ,  A61K31/7048

    CPC分类号： C07C69/84 ,  A23L33/105 ,  A61K31/235 ,  A61K31/7048 ,  Y10S514/885

    摘要： Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CH3 or an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplements containing such compounds. Methods for treating a condition in a mammal and for treating or ameliorating a condition, such as for example, chronic obstructive pulmonary disease (COPD) by administering an effective amount of a composition containing such compounds are also provided. Further provided is an extract obtained from the fruit of Myrciaria cauliflora containing at least one compound of the present invention in substantially pure form.

    摘要翻译： 提供了通过向细胞施用有效量的底部或花青素来调节细胞中趋化因子水平的方法。 更具体地，涉及通过向细胞施用有效量的具有式（IV）结构的底物：通式（Ⅳ），其中R选自H或CH 3或花青素，调节细胞中趋化因子水平的方法。 选自花青素3-葡萄糖苷，花翠素-3-葡萄糖苷或其组合，或其对映体，旋光异构体，非对映异构体，N-氧化物，结晶形式，水合物或其药学上可接受的盐。 还提供了根据式I-IV的化合物，药物组合物，单位剂型，以及含有这些化合物的食品或饲料添加剂。 还提供了通过施用有效量的含有这些化合物的组合物来治疗哺乳动物状况和治疗或改善病症的方法，例如慢性阻塞性肺病（COPD）。 进一步提供了从含有至少一种基本上纯的形式的本发明化合物的金丝桃的果实获得的提取物。

    Therapeutic treatment of chronic obstructive pulmonary disease
    3.
    发明授权
    Therapeutic treatment of chronic obstructive pulmonary disease 失效
    慢性阻塞性肺疾病的治疗方法

    公开(公告)号：US07309578B2

    公开(公告)日：2007-12-18

    申请号：US10204496

    申请日：2001-02-28

    申请人： Jeanine D'Armiento ,  Kazushi Imai

    发明人： Jeanine D'Armiento ,  Kazushi Imai

    IPC分类号： G01N33/50 ,  C12Q1/68 ,  C12Q1/37 ,  C12Q1/48

    CPC分类号： C12Q1/6883 ,  A61K38/195 ,  A61K48/00 ,  C07K16/18 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N2800/122

    摘要： The present invention provides a method of treating or preventing a chronic obstructive pulmonary disease in a subject, comprising administering to said subject an amount of an agent affective to inhibit apoptosis of the subject's lung cells and thus treat or prevent chronic obstructive pulmonary disease in the subject. The present invention provides for a method of diagnosing the disease. Also, the invention provides a method for identifying a compound effective to treat or prevent a chronic obstructive pulmonary disease, comprising (a) contacting lung cells from a subject having a chronic obstructive pulmonary disease with the compound and measuring the level of apoptosis of the lung cells in the presence of said compound, (b) measuring the level of apoptosis of the lung cells from the same subject in the absence of said compound, (c) comparing the level of apoptosis in step (a) with the level of apoptosis in step (b), wherein a higher level of apoptosis in step (b) indicate that the compound is effective to treat or prevent chronic obstructive pulmonary disease.

    摘要翻译： 本发明提供了治疗或预防受试者的慢性阻塞性肺疾病的方法，包括向所述受试者施用一定量的有效抑制受试者肺细胞凋亡的药剂，从而治疗或预防受试者的慢性阻塞性肺疾病 。 本发明提供了一种诊断疾病的方法。 此外，本发明提供了鉴定有效治疗或预防慢性阻塞性肺疾病的化合物的方法，其包括（a）使来自具有慢性阻塞性肺疾病的受试者的肺细胞与该化合物接触并测量肺细胞凋亡水平 在所述化合物存在下，（b）在不存在所述化合物的情况下测量来自相同受试者的肺细胞凋亡水平，（c）将步骤（a）中的凋亡水平与凋亡水平 步骤（b），其中步骤（b）中较高程度的凋亡表明该化合物有效治疗或预防慢性阻塞性肺疾病。

    USE OF MATRIX METALLOPROTEINASE INHIBITORS TO TREAT TUBERCULOSIS
    6.
    发明申请
    USE OF MATRIX METALLOPROTEINASE INHIBITORS TO TREAT TUBERCULOSIS 有权
    使用MATRIX金属蛋白酶抑制剂治疗TUBCCOSOSIS

    公开(公告)号：US20140199289A1

    公开(公告)日：2014-07-17

    申请号：US14000134

    申请日：2012-02-17

    申请人： Jeanine D'armiento ,  Paul Elkington

    发明人： Jeanine D'armiento ,  Paul Elkington

    IPC分类号： A61K38/55 ,  A61K31/65 ,  A61K38/48

    CPC分类号： A61K38/55 ,  A61K31/166 ,  A61K31/197 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/65 ,  A61K38/4886

    摘要： The present invention provides a method for treating a subject suffering from tuberculosis which comprises administering to the subject a composition comprising an amount of an inhibitor of a matrix metalloproteinase (MMP) in an amount effective to treat the subject, such that the therapeutic effect of said composition is different than the therapeutic effect attributable to the antibiotic properties of said composition. The present invention also provides a method for reducing or inhibiting destruction of lung extracellular matrix in a subject comprising administering to the subject at risk for such destruction a composition comprising an amount of an inhibitor of a matrix metalloproteinase (MMP) in an amount effective to reduce or inhibit destruction of lung extracellular matrix in the subject.

    摘要翻译： 本发明提供一种治疗患有结核病的受试者的方法，其包括给予受试者包含一定量的有效治疗受试者的量的基质金属蛋白酶（MMP）抑制剂的组合物，使得所述治疗效果 组合物不同于归因于所述组合物的抗生素性质的治疗效果。 本发明还提供了减少或抑制受试者中肺细胞外基质破坏的方法，其包括给具有这种破坏风险的受试者施用含有一定量的基质金属蛋白酶抑制剂（MMP） 或抑制受试者中肺细胞外基质的破坏。

    Use of metalloproteinase inhibitors in the treatment and prevention of pulmonary emphysema
    7.
    发明授权
    Use of metalloproteinase inhibitors in the treatment and prevention of pulmonary emphysema 失效
    使用金属蛋白酶抑制剂治疗和预防肺气肿

    公开(公告)号：US06608112B1

    公开(公告)日：2003-08-19

    申请号：US09530617

    申请日：2000-10-10

    申请人： Jeanine D'Armiento ,  Kiran Chada

    发明人： Jeanine D'Armiento ,  Kiran Chada

    IPC分类号： A61K3119

    CPC分类号： H01L23/26 ,  A61K31/00 ,  A61K31/381 ,  A61K31/4166 ,  A61K31/65 ,  H01L2924/0002 ,  H01L2924/00

    摘要： The invention provides a use of a metalloproteinase inhibitor for the preparation of a pharmaceutical composition for treating human pulmonary emphysema which comprises admixing the metalloproteinase inhibitor in an amount effective to treat human pulmonary emphysema and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition which comprises a metalloproteinase inhibitor in an amount effective to treat human pulmonary emphysema and a pharmaceutically acceptable carrier.

    摘要翻译： 本发明提供金属蛋白酶抑制剂用于制备治疗人肺气肿的药物组合物的用途，其包括将金属蛋白酶抑制剂以有效治疗人肺气肿的量和药学上可接受的载体混合。 本发明还提供一种药物组合物，其包含有效治疗人肺气肿的量的金属蛋白酶抑制剂和药学上可接受的载体。

    BIOACTIVE DEPSIDE AND ANTHOCYANIN COMPOUNDS, COMPOSITIONS, AND METHODS OF USE
    9.
    发明申请
    BIOACTIVE DEPSIDE AND ANTHOCYANIN COMPOUNDS, COMPOSITIONS, AND METHODS OF USE 审中-公开
    生物灭活剂和蒽醌化合物，组合物和使用方法

    公开(公告)号：US20150011629A1

    公开(公告)日：2015-01-08

    申请号：US14492725

    申请日：2014-09-22

    申请人： Jeanine D'Armiento ,  Kurt Reynertson ,  Edward Kennelly ,  Alison Wallace

    发明人： Jeanine D'Armiento ,  Kurt Reynertson ,  Edward Kennelly ,  Alison Wallace

    IPC分类号： C07C69/84

    CPC分类号： C07C69/84 ,  A23L33/105 ,  A61K31/235 ,  A61K31/7048 ,  Y10S514/885

    摘要： Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CH3 or an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplements containing such compounds. Methods for treating a condition in a mammal and for treating or ameliorating a condition, such as for example, chronic obstructive pulmonary disease (COPD) by administering an effective amount of a composition containing such compounds are also provided. Further provided is an extract obtained from the fruit of Myrciaria cauliflora containing at least one compound of the present invention in substantially pure form.

    摘要翻译： 提供了通过向细胞施用有效量的底部或花青素来调节细胞中趋化因子水平的方法。 更具体地，涉及通过向细胞施用有效量的具有式（IV）结构的底物：通式（Ⅳ），其中R选自H或CH 3或花青素，调节细胞中趋化因子水平的方法。 选自花青素3-葡萄糖苷，花翠素-3-葡萄糖苷或其组合，或其对映体，旋光异构体，非对映异构体，N-氧化物，结晶形式，水合物或其药学上可接受的盐。 还提供了根据式I-IV的化合物，药物组合物，单位剂型，以及含有这些化合物的食品或饲料添加剂。 还提供了通过施用有效量的含有这些化合物的组合物来治疗哺乳动物状况和治疗或改善病症的方法，例如慢性阻塞性肺病（COPD）。 进一步提供了从含有至少一种基本上纯的形式的本发明化合物的金丝桃的果实获得的提取物。

    Bioactive Depside and Anthocyanin Compounds, Compositions, and Methods of Use
    10.
    发明申请
    Bioactive Depside and Anthocyanin Compounds, Compositions, and Methods of Use 有权
    生物活性剂和花青素化合物，组合物和使用方法

    公开(公告)号：US20110110885A1

    公开(公告)日：2011-05-12

    申请号：US12309804

    申请日：2007-07-31

    申请人： Jeanine D'Armiento ,  Kurt Reynertson ,  Edward Kennelly ,  Alison Wallace

    发明人： Jeanine D'Armiento ,  Kurt Reynertson ,  Edward Kennelly ,  Alison Wallace

    IPC分类号： A61K31/235 ,  A61K31/7048 ,  A61P29/00 ,  A61P35/00 ,  A61P9/00 ,  A61P11/00 ,  A61P19/02 ,  A61K33/36 ,  A61K31/704 ,  A61K33/24 ,  A61K31/282 ,  A61K31/4164 ,  A61K31/675 ,  A61K38/21 ,  A61K38/20 ,  A61K39/395 ,  C07C69/84 ,  C12N5/071 ,  C12N5/09

    CPC分类号： C07C69/84 ,  A23L33/105 ,  A61K31/235 ,  A61K31/7048 ,  Y10S514/885

    摘要： Methods for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside or an anthocyanin are provided. More particularly, a method for modulating the level of a chemokine in a cell by administering to a cell an effective amount of a depside having the structure of formula (IV): Formula (IV) wherein R is selected from H or CH3 or an anthocyanin selected from cyanidin 3-glucoside, delphinidin 3-glucoside, or combinations thereof, or an enantiomer, optical isomer, diastereomer, N-oxide, crystalline form, hydrate, or pharmaceutically acceptable salt thereof is provided. Also provided are compounds according to Formulas I-IV, pharmaceutical compositions, unit dosage forms, and food or feed supplements containing such compounds. Methods for treating a condition in a mammal and for treating or ameliorating a condition, such as for example, chronic obstructive pulmonary disease (COPD) by administering an effective amount of a composition containing such compounds are also provided. Further provided is an extract obtained from the fruit of Myrciaria cauliflora containing at least one compound of the present invention in substantially pure form.

    摘要翻译： 提供了通过向细胞施用有效量的底部或花青素来调节细胞中趋化因子水平的方法。 更具体地，涉及一种通过向细胞施用有效量的具有式（IV）结构的底物：式（IV）的方法，其中R选自H或CH 3或花青素 选自花青素3-葡萄糖苷，花翠素-3-葡萄糖苷或其组合，或其对映体，旋光异构体，非对映异构体，N-氧化物，结晶形式，水合物或其药学上可接受的盐。 还提供了根据式I-IV的化合物，药物组合物，单位剂型，以及含有这些化合物的食品或饲料添加剂。 还提供了通过施用有效量的含有这些化合物的组合物来治疗哺乳动物状况和治疗或改善病症的方法，例如慢性阻塞性肺病（COPD）。 进一步提供了从含有至少一种基本上纯的形式的本发明化合物的金丝桃的果实获得的提取物。