公开(公告)号：US09684106B2

公开(公告)日：2017-06-20

申请号：US13500467

申请日：2010-10-08

Applicant: George Barbastathis ,  Yuan Luo ,  Raymond K. Kostuk ,  Jennifer K. Barton

Inventor： George Barbastathis ,  Yuan Luo ,  Raymond K. Kostuk ,  Jennifer K. Barton

IPC: G02B5/32 ,  G03H1/02 ,  G03H1/28 ,  G03H1/04

CPC classification number: G03H1/2286 ,  G02B5/32 ,  G03H1/0248 ,  G03H1/041 ,  G03H1/28 ,  G03H2001/0033 ,  G03H2001/0072 ,  G03H2001/0264 ,  G03H2001/0268 ,  G03H2001/2244 ,  G03H2001/266 ,  G03H2210/45 ,  G03H2223/55

Abstract: A volume holographic imaging system, apparatus, and/or method enables the projection of a two-dimensional (2D) slice of a four-dimensional (4D) probing object. A 4D probing source object is illuminated to emit or scatter an optical field. A holographic element having one or more recorded holograms receives and diffracts the optical field into a diffracted plane beam having spectral information. A 4-f telecentric relay system includes a pupil filter on the relayed conjugate plane of the volume hologram and images the pupil of the volume hologram onto the front focal plane of the collector lens. A collector lens focuses the diffracted plane beam to a 2D slice of the 4D probing source object. The focused 2D slice is projected onto a 2D imaging plane. The holographic element may have multiple multiplexed holograms that are arranged to diffract light from the corresponding slice of the 4D probing source object.

公开(公告)号：US09360611B2

公开(公告)日：2016-06-07

申请号：US13500461

申请日：2010-10-08

Applicant: George Barbastathis ,  Yuan Luo ,  Se Baek Oh ,  Jennifer K. Barton ,  Raymond K. Kostuk

Inventor： George Barbastathis ,  Yuan Luo ,  Se Baek Oh ,  Jennifer K. Barton ,  Raymond K. Kostuk

IPC: G03H1/28 ,  G02B5/32 ,  G03H1/02

CPC classification number: G03H1/2286 ,  G02B5/32 ,  G03H1/0248 ,  G03H1/041 ,  G03H1/28 ,  G03H2001/0033 ,  G03H2001/0072 ,  G03H2001/0264 ,  G03H2001/0268 ,  G03H2001/2244 ,  G03H2001/266 ,  G03H2210/45 ,  G03H2223/55

Abstract: A volume holographic imaging system, apparatus and/or method enables the projection of a two-dimensional (2D) slice of a four-dimensional (4D) probing object A 4D probing source object is illuminated to emit or scatter an optical field. A holographic element having one or more recorded holograms receives and diffracts the optical field into a diffracted plane beam having spectral information. A 4-ftelecentric relay system includes a pupil filter on the relayed conjugate plane of the volume hologram and images the pupil of the volume hologram onto the front focal plane of the collector lens. A collector lens focuses the diffracted plane beam to a 2D slice of the 4D probing source object. The focused 2D slice is projected onto a 2D imaging plane. The holographic element may have multiple multiplexed holograms that are arranged to diffract light from the corresponding slice of the 4D probing source object.

Abstract translation: 体积全息成像系统，装置和/或方法使得四维（4D）探测对象的二维（2D）切片的投影使得4D扫描源对象被照亮以发射或散射光场。 具有一个或多个记录的全息图的全息元件接收并将光场衍射成具有光谱信息的衍射平面光束。 4位中心继电器系统包括在体积全息图的中继共轭平面上的光瞳滤波器，并将体积全息图的瞳孔成像到收集透镜的前焦平面上。 收集透镜将衍射平面光束聚焦到4D探测源对象的2D切片。 聚焦的2D切片投影到2D成像平面上。 全息元件可以具有多个多路复用全息图，其被布置为衍射来自4D探测源对象的相应切片的光。

公开(公告)号：US20080228033A1

公开(公告)日：2008-09-18

申请号：US11994713

申请日：2006-06-30

Applicant: Alexandre R. Tumlinson ,  Jennifer K. Barton ,  Wolfgang Drexler ,  Boris Povazay

Inventor： Alexandre R. Tumlinson ,  Jennifer K. Barton ,  Wolfgang Drexler ,  Boris Povazay

IPC: A61B1/04

CPC classification number: G02B23/2423 ,  A61B1/00096 ,  A61B1/00165 ,  A61B1/00172 ,  A61B1/00188 ,  A61B5/0066

Abstract: Optical coherence tomograph (OCT) probe device (1) comprising an endoscope (6) which is adapted to be coupled to a light source (2) and has a distal tip portion (6.2), the tip portion (6.2) including focussing lens means (11) and a window (5) for directing light to a subject (7) to be scanned, and for receiving light scattered at the subject (7), to send the scattered light back through the endoscope (6) so that it may be applied to a detector (3) together with reference light, said OCT probe device (1) comprising a beam splitter (13; 17) to separate said reference light from the remaining light, as well as a reference light reflector (4; 20) for reflecting the reference light back so that it is composed to the light returned from the subject (7); the beam splitter (13; 17) and the reference light reflector (4; 20) are located in the tip portion (6.2) of the endoscope means (6) behind the focussing lens means (11) through which the composed light is sent back.

Abstract translation: 光学相干断层扫描仪（OCT）探针装置（1）包括适于联接到光源（2）并具有远端尖端部分（6.2）的内窥镜（6），所述尖端部分（6.2）包括聚焦透镜装置 （11）和用于将光引导到待扫描的被摄体（7）的窗口（5），并且用于接收在被摄体（7）处散射的光，以将散射的光发射回内窥镜（6），使得其可以 与参考光一起施加到检测器（3），所述OCT探针装置（1）包括分离器（13; 17）以将所述参考光与剩余的光分离，以及参考光反射器（4; 20 ），用于反射参考光，使得其与从被摄体（7）返回的光组成; 分束器（13; 17）和参考光反射器（4; 20）位于聚焦透镜装置（11）后面的内窥镜装置（6）的顶端部分（6.2）中，组合光通过该顶端部分 。

公开(公告)号：US20120307326A1

公开(公告)日：2012-12-06

申请号：US13500467

申请日：2010-10-08

Applicant: George Barbastathis ,  Yuan Luo ,  Raymond K. Kostuk ,  Jennifer K. Barton

Inventor： George Barbastathis ,  Yuan Luo ,  Raymond K. Kostuk ,  Jennifer K. Barton

IPC: G02B5/32

CPC classification number: G03H1/2286 ,  G02B5/32 ,  G03H1/0248 ,  G03H1/041 ,  G03H1/28 ,  G03H2001/0033 ,  G03H2001/0072 ,  G03H2001/0264 ,  G03H2001/0268 ,  G03H2001/2244 ,  G03H2001/266 ,  G03H2210/45 ,  G03H2223/55

Abstract: A volume holographic imaging system, apparatus, and/or method enables the projection of a two-dimensional (2D) slice of a four-dimensional (4D) probing object A 4D probing source object is illuminated to emit or scatter an optical field A holographic element having one or more recorded holograms receives and diffracts the optical field into a diffracted plane beam having spectral information A 4-ftelecentπc relay system includes a pupil filter on the relayed conjugate plane of the volume hologram and images the pupil of the volume hologram onto the front focal plane of the collector lens A collector lens focuses the diffracted plane beam to a 2D slice of the 4D probing source object The focused 2D slice is projected onto a 2D imaging plane The holographic element may have multiple multiplexed holograms that are arranged to diffract light from the corresponding slice of the 4D probing source object.

Abstract translation: 体积全息成像系统，装置和/或方法使得能够投影四维（4D）探测对象的二维（2D）切片4D扫描源对象被照射以发射或散射光场A全息 具有一个或多个记录的全息图的元件接收并将光场衍射成具有光谱信息的衍射平面光束。4中心系统包括在体积全息图的中继共轭平面上的光瞳滤波器，并且对体积全息图的瞳孔进行成像 到聚光透镜的前焦平面上。收集透镜将衍射平面光束聚焦到4D探测源对象的2D切片。将聚焦的2D切片投影到2D成像平面。全息元件可以具有多个复用的全息图， 从4D探测源对象的相应切片衍射光。

公开(公告)号：US06942663B2

公开(公告)日：2005-09-13

申请号：US10385195

申请日：2003-03-10

Applicant: Gracie Vargas ,  Jennifer K. Barton ,  Eric K. Chan ,  Thomas E. Milner ,  Ashley J. Welch

Inventor： Gracie Vargas ,  Jennifer K. Barton ,  Eric K. Chan ,  Thomas E. Milner ,  Ashley J. Welch

IPC: A61B18/20 ,  A61K31/045 ,  A61B18/14 ,  A61K31/40 ,  A61K47/06 ,  A61K47/46

CPC classification number: A61K31/045 ,  A61B18/203 ,  A61B2018/00452

Abstract: Methods for treating maladies such as cutaneous vascular lesions. A patient in need of vascular lesion treatment is identified. A hyperosmotic agent is administered to a region adjacent the lesion. Blood flow velocity is slowed within the region using the hyperosmotic agent, and the lesion is exposed to laser radiation.

Abstract translation: 治疗皮肤血管病变等疾病的方法。 确定需要血管病变治疗的患者。 向病变附近的区域施用渗透剂。 使用高渗透剂在该区域内血流速度变慢，病变暴露于激光辐射。

公开(公告)号：US06275726B1

公开(公告)日：2001-08-14

申请号：US09079991

申请日：1998-05-15

Applicant: Eric K. Chan ,  Jennifer K. Barton ,  Ashley J. Welch

Inventor： Eric K. Chan ,  Jennifer K. Barton ,  Ashley J. Welch

IPC: A61B500

CPC classification number: A61B5/1455 ,  A61B3/12 ,  A61B5/0059 ,  A61B5/0066 ,  A61B5/14532

Abstract: A new process to increase light transmission in biological tissue has been developed. The technique involves temporarily replacing tissue water with a fluid that has a refractive index closer to that of inter/intra cellular components. Subsequently, the amount of index mis-match between these components and the fluid environment is temporarily decreased. This lowers the amount of random reflection and refraction which also reduces light scattering. In addition, the infrared absorption is reduced when the fluid has a lower absorption coefficient than water. Furthermore, this process is reversible; thus creating a transient window to enhance light transmission for therapeutic and/or diagnostic applications.

Abstract translation: 已经开发了增加生物组织中光透射率的新方法。 该技术涉及用折射率更接近于细胞间/细胞内部件的折射率的液体临时替换组织水。 随后，这些组分与流体环境之间的指数失配量暂时降低。 这降低了随机反射和折射的量，这也减少了光散射。 此外，当流体具有比水更低的吸收系数时，红外吸收减小。 此外，这个过程是可逆的; 从而产生用于治疗和/或诊断应用的光透射的瞬时窗口。

公开(公告)号：US06766187B1

公开(公告)日：2004-07-20

申请号：US09664193

申请日：2000-09-18

Applicant: John F. Black ,  Jennifer K. Barton

Inventor： John F. Black ,  Jennifer K. Barton

IPC: A61B600

CPC classification number: A61B18/24 ,  A61B5/0059 ,  A61B5/0068 ,  A61B2017/00057

Abstract: Onset of coagulation of blood in a blood vessel irradiated by electromagnetic radiation is detected by directing light at the blood vessel and monitoring the intensity of a portion of the light remitted from the blood vessel. An increase or decrease in the monitored light intensity indicates the onset of coagulation. The increase or decrease results from the formation of methemoglobin in the blood which accompanies the onset of coagulation. The methemoglobin is formed by photo conversion or thermal conversion of normal blood oxyhemoglobin. The wavelength of the monitoring light is selected to be different from that of the electromagnetic radiation and is preferably a wavelength for which the ratio of its absorptivity in hemoglobin and its absorptivity in normal blood is less than about one-half or greater than about two.

Abstract translation: 通过将光引导到血管并监测从血管汇出的一部分光的强度来检测电磁辐射照射的血管中血液凝结的开始。 监测的光强度的增加或减少表明凝血的发生。 增加或减少是伴随凝血发作的血液中血红蛋白的形成。 高铁血红蛋白通过正常血氧血红蛋白的光转化或热转化而形成。 选择监视光的波长与电磁辐射的波长不同，并且优选地是其血红蛋白吸收率与其在正常血液中的吸收率之比小于约二分之一或大于二的波长。