公开(公告)号：US20150238631A1

公开(公告)日：2015-08-27

申请号：US14432065

申请日：2014-10-15

申请人： Chanhyuk Kim ,  Travis Young ,  Yu Cao ,  Jennifer Ma ,  Minsoo Kim ,  Stephanie A. Pinkerton ,  Peter G. Schultz

发明人： Chanhyuk Kim ,  Travis Young ,  Yu Cao ,  Jennifer Ma ,  Minsoo Kim ,  Stephanie A. Pinkerton ,  Peter G. Schultz

IPC分类号： A61K47/48 ,  C07K16/40 ,  A61K31/4188 ,  A61K39/385 ,  A61K31/352 ,  C07K16/28 ,  A61K39/395

CPC分类号： A61K47/6849 ,  A61K31/352 ,  A61K31/4188 ,  A61K39/385 ,  A61K39/3955 ,  A61K47/6835 ,  A61K49/0041 ,  A61K49/0058 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/32 ,  C07K16/40 ,  C07K16/44 ,  C07K2317/522 ,  C07K2317/567 ,  C07K2317/622

摘要： Disclosed herein are switches for regulating the activity of a chimeric antigen receptor effector cells (CAR-ECs). The switches generally comprise a chimeric antigen receptor-interacting domain (CAR-ID) and a target interacting domain (TID). The switch may further comprise a linker. Further disclosed herein are methods of using the switches for the treatment of one or more conditions or diseases in a subject in need thereof.

摘要翻译： 本文公开了用于调节嵌合抗原受体效应细胞（CAR-EC）的活性的开关。 开关通常包含嵌合抗原受体相互作用区域（CAR-ID）和靶相互作用区域（TID）。 该开关还可以包括接头。 本文进一步公开的是使用开关来治疗有需要的受试者中的一种或多种病症或疾病的方法。

公开(公告)号：US20220032679A1

公开(公告)日：2022-02-03

申请号：US16942910

申请日：2020-07-30

申请人： Wen Jennifer Ma

发明人： Wen Jennifer Ma

IPC分类号： B44C3/12 ,  B32B3/30 ,  B32B7/09 ,  B32B7/14 ,  B32B37/12

摘要： Disclosed is a method of making an extensible sculpture including providing a plurality of flexible material sheets; cutting each of the plurality of flexible material sheets to form a plurality of at least three sculptural pieces; arranging the sculptural pieces in a predetermined order; defining a first set of connection columns on the top face of the first sculptural piece; using a first connector to fixedly connect the bottom face of the second sculptural piece to the top face of the first sculptural piece at the first set of connection columns; defining a second set of connection columns on the top face of the second sculptural piece; and using a second connector to fixedly connect the bottom face of the third sculptural piece to the top face of the second sculptural piece at the second set of connection columns.

公开(公告)号：US20240286431A1

公开(公告)日：2024-08-29

申请号：US18636225

申请日：2024-04-15

申请人： Wen Jennifer Ma

发明人： Wen Jennifer Ma

IPC分类号： B44C3/12 ,  B32B37/12 ,  B32B38/00 ,  B44C3/02

CPC分类号： B44C3/12 ,  B32B37/1292 ,  B32B38/0004 ,  B44C3/02 ,  B32B2038/008 ,  B32B2451/00

摘要： Disclosed is a method of making an extensible sculpture including providing a plurality of flexible material sheets; cutting each of the plurality of flexible material sheets to form a plurality of at least three sculptural pieces; arranging the sculptural pieces in a predetermined order; defining a first set of connection columns on the top face of the first sculptural piece; using a first connector to fixedly connect the bottom face of the second sculptural piece to the top face of the first sculptural piece at the first set of connection columns; defining a second set of connection columns on the top face of the second sculptural piece; and using a second connector to fixedly connect the bottom face of the third sculptural piece to the top face of the second sculptural piece at the second set of connection columns.