公开(公告)号：US20080025981A1

公开(公告)日：2008-01-31

申请号：US11599845

申请日：2006-11-15

申请人： Paul Young ,  Reinhard Ebner ,  Zoe Weaver ,  Jeffrey Strovel ,  Stephen Horrigan ,  Martin Shea ,  Bernd Weigle ,  Michael Rieger ,  Jennifer Rick ,  Colyn Cain

发明人： Paul Young ,  Reinhard Ebner ,  Zoe Weaver ,  Jeffrey Strovel ,  Stephen Horrigan ,  Martin Shea ,  Bernd Weigle ,  Michael Rieger ,  Jennifer Rick ,  Colyn Cain

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/30 ,  C12Q1/68

CPC分类号： G01N33/5011 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with methods for assaying for potential antitumor agents based on their modulation of the expression of these cancer-related genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing cancer using the gene sequences as well as the polypeptide sequences.

摘要翻译： 公开了与癌基因序列和衍生的氨基酸序列，以及基于它们对这些癌症相关基因表达的调节来测定潜在的抗肿瘤剂的方法。 还公开了与所公开的多肽反应的抗体以及使用抗体治疗癌性病症的方法，例如使用抗体靶向靶细胞体内的癌细胞用于递送治疗剂的目的。 还描述了使用基因序列以及多肽序列诊断癌症的方法。

公开(公告)号：US20060228705A1

公开(公告)日：2006-10-12

申请号：US10516697

申请日：2003-06-05

申请人： Reinhard Ebner ,  Jennifer Rick

发明人： Reinhard Ebner ,  Jennifer Rick

IPC分类号： C12Q1/68 ,  G01N33/574 ,  C07H21/04 ,  C12P21/06 ,  C07K16/46 ,  C07K16/30 ,  C07K14/82

CPC分类号： C07K14/82 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/5011 ,  G01N33/57415 ,  G01N33/57442

摘要： Cancer-linked gene sequences, and derived amino acid sequences, are disclosed along with processes for assaying potential antitumor agents based on their modulation of the expression of these cancer-linked genes. Also disclosed are antibodies that react with the disclosed polypeptides and methods of using the antibodies to treat cancerous conditions, such as by using the antibody to target cancerous cells in vivo for purposes of delivering therapeutic agents thereto. Also described are methods of diagnosing using the gene sequences.