-
公开(公告)号:US06548667B2
公开(公告)日:2003-04-15
申请号:US10018507
申请日:2001-12-06
申请人: Young-Jun Park , Hae-Young Bae , Ji-Uk Yoo , Myeong-Yun Chae , Sang-Hyun Paek , Hye-Kyung Min , Hyun-Gyu Park , Choon-Ho Ryu , Kyung-Chul Kim , Jeoung-Wook Lee
发明人: Young-Jun Park , Hae-Young Bae , Ji-Uk Yoo , Myeong-Yun Chae , Sang-Hyun Paek , Hye-Kyung Min , Hyun-Gyu Park , Choon-Ho Ryu , Kyung-Chul Kim , Jeoung-Wook Lee
IPC分类号: C07D27768
CPC分类号: C07D417/12 , C07D277/74
摘要: The present invention provides a novel sulfonamide derivative of general formula (I) useful as an inhibitor of matrix metalloproteinase (MMP), its isomers, pharmaceutically acceptable salts thereof and a process for preparing the same. Since the sulfonamide derivatives of the present invention selectively inhibit MMP activity in vitro, the MMP inhibitors comprising the sulfonamide derivatives as an effective ingredient can be practically applied for the prevention and treatment of all sorts of diseases caused by overexpression and overactivation of MMP.