公开(公告)号：US20090163382A1

公开(公告)日：2009-06-25

申请号：US11863984

申请日：2007-09-28

申请人： Ji-Young OH ,  Yeon-su LEE ,  Sang-hyun PAEK ,  Byung-chul KIM ,  Sook-young KIM ,  Kyung-hee PARK ,  Jung-nam LEE ,  Jong-suk CHUNG ,  Ah-gi KIM ,  Myo-yong LEE ,  Tae-jin AHN

发明人： Ji-Young OH ,  Yeon-su LEE ,  Sang-hyun PAEK ,  Byung-chul KIM ,  Sook-young KIM ,  Kyung-hee PARK ,  Jung-nam LEE ,  Jong-suk CHUNG ,  Ah-gi KIM ,  Myo-yong LEE ,  Tae-jin AHN

IPC分类号： C40B40/08 ,  C07H21/04

CPC分类号： C12Q1/689 ,  C12Q2600/16

摘要： Provided are a primer set for amplifying target sequence(s) of antibiotic-resistant bacterial species, a probe or probe set specifically hybridizing with target sequence(s) of antibiotic-resistant bacterial species, a microarray immobilized with the probe or probe set, a kit comprising the primer set and a method of detecting at least one antibiotic-resistant bacterial species using the probe or probe set.

摘要翻译： 提供了用于扩增抗生素抗性细菌种类的靶序列的引物组，与抗生素抗性细菌种类的靶序列特异性杂交的探针或探针组，固定有探针或探针组的微阵列 包括引物组的试剂盒和使用探针或探针组检测至少一种抗生素抗性细菌物种的方法。

公开(公告)号：US20050271557A1

公开(公告)日：2005-12-08

申请号：US11106209

申请日：2005-04-14

申请人： Hun-joo Lee ,  Nam Huh ,  Sang-hyun Paek ,  Chang-eun Yoo

发明人： Hun-joo Lee ,  Nam Huh ,  Sang-hyun Paek ,  Chang-eun Yoo

IPC分类号： G01N33/52 ,  B01L9/00

CPC分类号： B01L9/52 ,  B01J2219/00608 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01L2300/0819

摘要： Provided is a microarray holding device. The microarray holding device includes: a solid substrate in the form of a plate in which an engaging-receiving portion for receiving a microarray substrate to be engaged therewith is formed, the engaging-receiving portion being composed of an opening; sidewalls to be aligned with sidewalls of the microarray substrate to be engaged with the engaging-receiving portion; and a base surface on which a top or bottom surface of the microarray substrate to be engaged with the engaging-receiving portion is to be placed, wherein the base surface is depressed from a top or bottom surface of the solid substrate such that the other surface of the microarray substrate is lower than the top or bottom surface of the solid substrate when the microarray substrate is engaged with the engaging-receiving portion.

摘要翻译： 提供了一种微阵列保持装置。 微阵列保持装置包括：形成板状的固体基板，其中形成用于接收与其接合的微阵列基板的接合部分，所述接合部分由开口构成; 与微阵列基板的侧壁对准以与接合部接合的侧壁; 以及要在其上放置要与所述接合部分接合的所述微阵列基板的顶表面或底表面的基面，其中所述基底表面从所述固体基底的顶表面或底表面压下，使得所述另一表面 的微阵列基板与接合部接合时，低于固体基板的顶面或底面。

公开(公告)号：US07659388B2

公开(公告)日：2010-02-09

申请号：US11862758

申请日：2007-09-27

申请人： Ji-young Oh ,  Sang-hyun Paek ,  Kyung-hee Park ,  Jung-nam Lee ,  Jong-suk Chung ,  Ah-gi Kim

发明人： Ji-young Oh ,  Sang-hyun Paek ,  Kyung-hee Park ,  Jung-nam Lee ,  Jong-suk Chung ,  Ah-gi Kim

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C12Q1/689 ,  C12Q2600/16 ,  Y02A50/451

摘要： Provided are a primer set for specifically amplifying target sequence(s) of twelve respiratory disease-causing bacterial species, a probe set specifically hybridizing with target sequence(s) of twelve respiratory disease-causing bacterial species, a microarray comprising the probe set, and a method of detecting a respiratory disease-causing bacterial species using the probe set.

摘要翻译： 提供了用于特异性扩增十二种呼吸道性疾病的细菌种类的靶序列的引物组，与12种呼吸道性疾病致细菌物种的靶序列特异性杂交的探针组，包含探针组的微阵列和 使用探针组检测呼吸系统疾病的细菌物种的方法。

公开(公告)号：US20080102142A1

公开(公告)日：2008-05-01

申请号：US11970261

申请日：2008-01-07

申请人： Sang Hyun PAEK ,  Christopher KO

发明人： Sang Hyun PAEK ,  Christopher KO

IPC分类号： A61K36/8962 ,  A61P43/00

CPC分类号： A61K31/105 ,  A61K31/145 ,  A61K36/8962

摘要： The present invention provides a composition for removing a hangover. In particular, the present invention discloses a method of using ajoene as an alcohol dehydrogenase inhibitor based on the fact that ajoene strongly inhibits alcohol dehydrogenase (ADH) activity. A composition for removing a hangover comprising ajoene suppresses the over-production of acetaldehyde during alcohol metabolism to maintain acetaldehyde concentration in blood at a normal level that can be degraded in the body and eliminated therefrom through normal metabolic and secretory pathways to thereby prevent the hangover after consumption of alcohol, and a method of preparing the same, are also provided. The present invention also provides a novel use of ajoene, which is a natural substance obtained by purification of garlic, and a composition for removing a hangover comprising ajoene, which is harmless to the body and strongly inhibits ADH activity, thereby showing very excellent relieving effect on the hangover.

摘要翻译： 本发明提供一种去除宿醉的组合物。 特别地，本发明公开了一种基于阿魏烯强烈抑制醇脱氢酶（ADH）活性的事实，使用邻苯二酚作为醇脱氢酶抑制剂的方法。 一种用于去除宿醉的组合物，其包含乙醇代谢过程中乙醛过量产生，以维持血液中的乙醛浓度达到正常水平，其能够通过正常代谢和分泌途径在体内降解，从而通过正常的代谢和分泌途径从而脱除，从而防止宿醉后的宿醉 还提供了饮用酒精及其制备方法。 本发明还提供了一种通过纯化大蒜获得的天然物质和一种用于除去宿醉的组合物的新颖用途，所述宿醉包括对人体无害的ADH活性，从而显示非常优异的缓解作用 在宿醉

公开(公告)号：US20080081770A1

公开(公告)日：2008-04-03

申请号：US11862758

申请日：2007-09-27

申请人： Ji-young OH ,  Sang-hyun PAEK ,  Kyung-hee PARK ,  Jung-nam LEE ,  Jong-suk CHUNG ,  Ah-gi KIM

发明人： Ji-young OH ,  Sang-hyun PAEK ,  Kyung-hee PARK ,  Jung-nam LEE ,  Jong-suk CHUNG ,  Ah-gi KIM

IPC分类号： C40B40/08

CPC分类号： C12Q1/689 ,  C12Q2600/16 ,  Y02A50/451

摘要： Provided are a primer set for specifically amplifying target sequence(s) of twelve respiratory disease-causing bacterial species, a probe set specifically hybridizing with target sequence(s) of twelve respiratory disease-causing bacterial species, a microarray comprising the probe set, and a method of detecting a respiratory disease-causing bacterial species using the probe set.

摘要翻译： 提供了用于特异性扩增十二种呼吸道性疾病的细菌种类的靶序列的引物组，与12种呼吸道性疾病致细菌物种的靶序列特异性杂交的探针组，包含探针组的微阵列和 使用探针组检测呼吸系统疾病的细菌物种的方法。

公开(公告)号：US08563696B2

公开(公告)日：2013-10-22

申请号：US12907604

申请日：2010-10-19

申请人： Kwang-ho Cheong ,  Sang-hyun Paek

发明人： Kwang-ho Cheong ,  Sang-hyun Paek

IPC分类号： C07K16/28 ,  C07K16/00 ,  A61K39/395 ,  C12N5/20

CPC分类号： C07K16/2863 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

摘要： Antibodies specifically binding to c-Met protein, hybridoma cell lines, and compositions comprising the antibodies are disclosed herein. Methods of making and using the antibodies and compositions are also disclosed.

摘要翻译： 本文公开了与c-Met蛋白，杂交瘤细胞系以及包含抗体的组合特异性结合的抗体。 还公开了制备和使用抗体和组合物的方法。

公开(公告)号：US20110129481A1

公开(公告)日：2011-06-02

申请号：US12807191

申请日：2010-08-30

申请人： Kwang Ho Cheong ,  Sung-young Jeong ,  Sang-hyun Paek

发明人： Kwang Ho Cheong ,  Sung-young Jeong ,  Sang-hyun Paek

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  C12N5/12 ,  G01N33/53 ,  A61P35/00 ,  C12N5/10 ,  C12N1/19

CPC分类号： G01N33/57407 ,  C07K16/2863 ,  C07K2317/33 ,  G01N33/57492

摘要： Antibodies specifically binding to c-Met protein, hybridoma cell lines, and compositions comprising the antibodies are disclosed herein. Methods of making and using the antibodies and compositions are also disclosed.

摘要翻译： 本文公开了与c-Met蛋白，杂交瘤细胞系以及包含抗体的组合特异性结合的抗体。 还公开了制备和使用抗体和组合物的方法。

公开(公告)号：US20080124769A1

公开(公告)日：2008-05-29

申请号：US11936321

申请日：2007-11-07

申请人： Sang-hyun PAEK ,  Jung-nam LEE

发明人： Sang-hyun PAEK ,  Jung-nam LEE

IPC分类号： C12P19/34 ,  C12M1/00

CPC分类号： B01L3/50853 ,  B01L3/50851 ,  B01L2200/141 ,  B01L2300/042 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2300/0851

摘要： Provided are a well plate for multiplex PCR including: a plurality of wells for multiplex PCR each well comprising at least two partitioned chambers formed by at least one barrier that extends in an upward direction from the bottom of the wells and has a lower height than the height of the wells, wherein the wells optionally comprise plugs that seal the partitioned chambers to be separated from each other, a multiplex PCR apparatus including the well plate, and a method of performing multiplex PCR using the multiplex PCR apparatus.

摘要翻译： 提供了一种用于多重PCR的孔板，其包括：用于多重PCR的多个孔，每个孔包括由至少一个屏障形成的至少两个分隔室，所述至少一个屏障从孔的底部沿向上的方向延伸，并且具有比 孔的高度，其中所述孔任选地包括密封彼此分离的分隔室的塞子，包括所述孔板的多重PCR装置以及使用所述多重PCR装置进行多重PCR的方法。

公开(公告)号：US06548667B2

公开(公告)日：2003-04-15

申请号：US10018507

申请日：2001-12-06

申请人： Young-Jun Park ,  Hae-Young Bae ,  Ji-Uk Yoo ,  Myeong-Yun Chae ,  Sang-Hyun Paek ,  Hye-Kyung Min ,  Hyun-Gyu Park ,  Choon-Ho Ryu ,  Kyung-Chul Kim ,  Jeoung-Wook Lee

发明人： Young-Jun Park ,  Hae-Young Bae ,  Ji-Uk Yoo ,  Myeong-Yun Chae ,  Sang-Hyun Paek ,  Hye-Kyung Min ,  Hyun-Gyu Park ,  Choon-Ho Ryu ,  Kyung-Chul Kim ,  Jeoung-Wook Lee

IPC分类号： C07D27768

CPC分类号： C07D417/12 ,  C07D277/74

摘要： The present invention provides a novel sulfonamide derivative of general formula (I) useful as an inhibitor of matrix metalloproteinase (MMP), its isomers, pharmaceutically acceptable salts thereof and a process for preparing the same. Since the sulfonamide derivatives of the present invention selectively inhibit MMP activity in vitro, the MMP inhibitors comprising the sulfonamide derivatives as an effective ingredient can be practically applied for the prevention and treatment of all sorts of diseases caused by overexpression and overactivation of MMP.

公开(公告)号：US08546544B2

公开(公告)日：2013-10-01

申请号：US12807191

申请日：2010-08-30

申请人： Kwang-ho Cheong ,  Sung-young Jeong ,  Sang-hyun Paek

发明人： Kwang-ho Cheong ,  Sung-young Jeong ,  Sang-hyun Paek

IPC分类号： C07K16/26 ,  C07K16/00 ,  C12N5/20 ,  C12N15/00 ,  C12N15/87 ,  C07H21/04

CPC分类号： G01N33/57407 ,  C07K16/2863 ,  C07K2317/33 ,  G01N33/57492

摘要： Antibodies specifically binding to c-Met protein, hybridoma cell lines, and compositions comprising the antibodies are disclosed herein. Methods of making and using the antibodies and compositions are also disclosed.

摘要翻译： 本文公开了与c-Met蛋白，杂交瘤细胞系以及包含抗体的组合特异性结合的抗体。 还公开了制备和使用抗体和组合物的方法。