公开(公告)号：US06548667B2

公开(公告)日：2003-04-15

申请号：US10018507

申请日：2001-12-06

申请人： Young-Jun Park ,  Hae-Young Bae ,  Ji-Uk Yoo ,  Myeong-Yun Chae ,  Sang-Hyun Paek ,  Hye-Kyung Min ,  Hyun-Gyu Park ,  Choon-Ho Ryu ,  Kyung-Chul Kim ,  Jeoung-Wook Lee

发明人： Young-Jun Park ,  Hae-Young Bae ,  Ji-Uk Yoo ,  Myeong-Yun Chae ,  Sang-Hyun Paek ,  Hye-Kyung Min ,  Hyun-Gyu Park ,  Choon-Ho Ryu ,  Kyung-Chul Kim ,  Jeoung-Wook Lee

IPC分类号： C07D27768

CPC分类号： C07D417/12 ,  C07D277/74

摘要： The present invention provides a novel sulfonamide derivative of general formula (I) useful as an inhibitor of matrix metalloproteinase (MMP), its isomers, pharmaceutically acceptable salts thereof and a process for preparing the same. Since the sulfonamide derivatives of the present invention selectively inhibit MMP activity in vitro, the MMP inhibitors comprising the sulfonamide derivatives as an effective ingredient can be practically applied for the prevention and treatment of all sorts of diseases caused by overexpression and overactivation of MMP.

公开(公告)号：US06825355B2

公开(公告)日：2004-11-30

申请号：US10032609

申请日：2001-10-26

申请人： Jagabandhu Das ,  Joel C. Barrish ,  John Wityak

发明人： Jagabandhu Das ,  Joel C. Barrish ,  John Wityak

IPC分类号： C07D27768

CPC分类号： C07D417/12 ,  A61K31/425 ,  C07D277/82 ,  C07F7/0812 ,  A61K2300/00

摘要： Novel benzothiazoles and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic disorders.

摘要翻译： 新颖的苯并噻唑及其盐，含有这些化合物的药物组合物，以及使用这些化合物治疗蛋白质酪氨酸激酶相关病症如免疫疾病的方法。