公开(公告)号：US5071034A

公开(公告)日：1991-12-10

申请号：US534459

申请日：1990-06-06

申请人： Jerome Corbiere

发明人： Jerome Corbiere

IPC分类号： A61J1/00 ,  A61J1/20 ,  B65D81/32

CPC分类号： A61J1/2089 ,  B65D81/3211 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2027 ,  A61J1/2093

摘要： In a distributing device for liquid preparation composed of three parts forming a single unit consisting of a receptacle, an intermediate part of a flexible texture forming a bellows fixed on the neck of the receptacle and an upper part mounted on the top of the bellows forming a reservoir finished by a nozzle closed at its ends. The intermediate part is composed of a flexible sleeve formed of several concentric rings joined together, inside which are arranged two impervious membranes separated by a rigid member having two sharpened extremities arranged vertically, perpendicular to each of the two membranes.

摘要翻译： 在用于液体制备的分配装置中，由形成由容器组成的单个单元的三个部分组成，形成固定在容器的颈部上的波纹管的柔性织构的中间部分和安装在波纹管的顶部上的上部形成 储存器由其端部封闭的喷嘴完成。 中间部分是由连接在一起的几个同心环形成的柔性套管构成的，其中布置有两个不透水膜，两个不透水膜由刚性构件分开，两个刚性构件垂直于两个膜垂直排列。

公开(公告)号：US4988683A

公开(公告)日：1991-01-29

申请号：US383027

申请日：1989-07-20

申请人： Jerome Corbiere

发明人： Jerome Corbiere

IPC分类号： A61K9/00 ,  A61K9/68

CPC分类号： A61K31/621 ,  A61K31/60 ,  A61K9/0056 ,  A61K9/0058

摘要： This invention relates to the field of pharmaceutical chemistry and more precisely to the field of galenical pharmacy.It refers to new pharmaceutical compositions intended for the buccal tract, the active ingredient of which is lysine acetylsalicylate in association or mixed with one or several excipients and/or diluents adapted to achieve a pharmaceutical form which may be sucked or chewed. A process for the production of said pharmaceutical composition is also described.

摘要翻译： 本发明涉及药物化学领域，更准确地涉及盖仑制药领域。 它是指用于口腔的新的药物组合物，其活性成分是与乙酰水杨酸赖氨酸相关联或与一种或几种适于实现可吸入或咀嚼的药物形式的赋形剂和/或稀释剂混合。 还描述了用于生产所述药物组合物的方法。

公开(公告)号：US5523082A

公开(公告)日：1996-06-04

申请号：US105342

申请日：1993-08-09

申请人： Jerome Corbiere

发明人： Jerome Corbiere

IPC分类号： A61K9/00 ,  A61K31/48 ,  A61K3/38 ,  A61K9/08

CPC分类号： A61K9/0048 ,  A61K31/48

摘要： The invention relates to new pharmaceutical compositions intended for administration by ocular route and to the process for obtaining them.A specific subject of the invention is a process for obtaining pharmaceutical compositions intended for ophthalmic route of which the active ingredient is bromocriptine, in which the active ingredient is dissolved in methanol then this solution is diluted with an aqueous solute containing a hydrosoluble inert filler, the mixture is lyophilized then the lyophilization deposit is redissolved at the time of use in an aqueous solute containing a preservative, a polyethylene glycol, physiological serum and an ethylenic acid.The solute obtained is a medicament for intra-ocular hypertension.

摘要翻译： 本发明涉及旨在通过眼睛途径施用的新的药物组合物以及获得它们的方法。 本发明的具体目的是获得用于眼用途的药物组合物的方法，其中活性成分是溴隐亭，其中活性成分溶解在甲醇中，然后用含有水溶性惰性填料的水性溶质稀释该溶液， 将混合物冻干，然后将冻干沉积物在使用时再次溶解于含有防腐剂，聚乙二醇，生理血清和乙烯酸的水溶液中。 获得的溶质是用于眼内高血压的药物。

公开(公告)号：US4794117A

公开(公告)日：1988-12-27

申请号：US103451

申请日：1987-09-30

申请人： Jerome Corbiere

发明人： Jerome Corbiere

IPC分类号： C07D209/28 ,  A61K9/00 ,  A61K31/40 ,  A61K47/00 ,  A61K47/10

CPC分类号： A61K47/10 ,  A61K9/0019

摘要： This invention relates to a novel process for solubilizing the hydrophobic organic compounds--and namely the pharmaceutical active ingredients--in an aqueous phase.This process is defined in that the hydrophobic compound is prior dissolved in one or several polymers of high molecular weight, then adding to this solution an aqueous medium the pH of which is fixed.The aqueous solutions thus resulting are useful for preparing medicines for parenteral, digestive, mucous or transcutaneous administration.

摘要翻译： 本发明涉及在水相中增溶疏水性有机化合物 - 即药物活性成分的新方法。 该方法的定义是疏水性化合物先前溶解在一种或几种高分子量聚合物中，然后向该溶液中加入其pH固定的水性介质。 由此得到的水溶液可用于制备肠胃外，消化，粘液或经皮给药的药物。