公开(公告)号：US20150320733A1

公开(公告)日：2015-11-12

申请号：US14651491

申请日：2013-12-17

申请人： Scott B. HOYT ,  Jerry Andrew TAYLOR ,  Clare LONDON ,  Yusheng XIONG ,  Andrew John COOKE ,  MERCK SHARP & DOHME CORP.

发明人： Scott B. Hoyt ,  Jerry Andrew Taylor ,  Clare London ,  Yusheng Xiong ,  Andrew John Cooke

IPC分类号： A61K31/4439 ,  A61K31/497 ,  C07D403/14 ,  C07D401/04 ,  A61K31/4725

CPC分类号： A61K31/4439 ,  A61K31/4725 ,  A61K31/497 ,  C07D401/04 ,  C07D403/04 ,  C07D403/14

摘要： This invention relates to indazole compounds of the structural formula: (structure represented) or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment or amelioration of conditions that could be treated by inhibiting aldosterone synthase.

摘要翻译： 本发明涉及结构式为（结构式）的吲唑化合物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及可能用于治疗或改善可通过抑制醛固酮合酶治疗的病症的方法。

公开(公告)号：US09173873B2

公开(公告)日：2015-11-03

申请号：US14346403

申请日：2012-09-17

申请人： Amjad Ali ,  D. Jonathan Bennett ,  Jaiqiang Cai ,  Emma Carswell ,  Andrew Cooke ,  Scott B. Hoyt ,  Michael Lo ,  Clare London ,  John MacLean ,  Min K. Park ,  Paul Ratcliffe ,  Jerry Andrew Taylor ,  Brent Whitehead ,  Yusheng Xiong

发明人： Amjad Ali ,  D. Jonathan Bennett ,  Jaiqiang Cai ,  Emma Carswell ,  Andrew Cooke ,  Scott B. Hoyt ,  Michael Lo ,  Clare London ,  John MacLean ,  Min K. Park ,  Paul Ratcliffe ,  Jerry Andrew Taylor ,  Brent Whitehead ,  Yusheng Xiong

IPC分类号： A61K31/437 ,  C07D471/04 ,  C07D487/04

摘要： This invention relates to imidazopyridyl compounds of the structural formula: I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as potentially to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthase.

公开(公告)号：US09073929B2

公开(公告)日：2015-07-07

申请号：US14112945

申请日：2012-04-20

申请人： Scott B. Hoyt ,  Whitney Lane Petrilli ,  Clare London ,  Yusheng Xiong ,  Jerry Andrew Taylor ,  Amjad Ali ,  Michael Man-Chu Lo ,  Timothy J. Henderson ,  Qingzhong Hu ,  Rolf Hartmann ,  Lina Yin ,  Ralf Heim ,  Emmanuel Bey ,  Rohit Saxena ,  Swapan Kumar Samanta ,  Bheemashankar A. Kulkarni

发明人： Scott B. Hoyt ,  Whitney Lane Petrilli ,  Clare London ,  Yusheng Xiong ,  Jerry Andrew Taylor ,  Amjad Ali ,  Michael Man-Chu Lo ,  Timothy J. Henderson ,  Qingzhong Hu ,  Rolf Hartmann ,  Lina Yin ,  Ralf Heim ,  Emmanuel Bey ,  Rohit Saxena ,  Swapan Kumar Samanta ,  Bheemashankar A. Kulkarni

IPC分类号： C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61K31/41 ,  A61K45/06

CPC分类号： C07D487/04 ,  A61K31/41 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00 ,  A61K2300/00

摘要： This invention relates to tricyclic triazole analogs of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

摘要翻译： 本发明涉及式I的三环三唑类似物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合成酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及用于治疗，改善或预防可通过抑制醛固酮合成酶治疗的病症的方法。

公开(公告)号：US20140045819A1

公开(公告)日：2014-02-13

申请号：US14112945

申请日：2012-04-20

申请人： Scott B. Hoyt ,  Whitney Lane Petrilli ,  Clare London ,  Yusheng Xiong ,  Jerry Andrew Taylor ,  Amjad Ali ,  Michael Man-Chu Lo ,  Timothy J. Henderson ,  Qingzhong Hu ,  Rolf Hartmann ,  Lina Yin ,  Ralf Heim ,  Emmanuel Bey ,  Rohit Saxena ,  Swapan Kumar Samanta ,  Bheemashankar A. Kulkarni

发明人： Scott B. Hoyt ,  Whitney Lane Petrilli ,  Clare London ,  Yusheng Xiong ,  Jerry Andrew Taylor ,  Amjad Ali ,  Michael Man-Chu Lo ,  Timothy J. Henderson ,  Qingzhong Hu ,  Rolf Hartmann ,  Lina Yin ,  Ralf Heim ,  Emmanuel Bey ,  Rohit Saxena ,  Swapan Kumar Samanta ,  Bheemashankar A. Kulkarni

IPC分类号： C07D487/04 ,  C07D471/04

CPC分类号： C07D487/04 ,  A61K31/41 ,  A61K45/06 ,  C07D471/04 ,  C07D519/00 ,  A61K2300/00

摘要： This invention relates to tricyclic triazole analogues of the formula I or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldosterone synthetase. This invention also provides for pharmaceutical compositions comprising the compounds of Formula I or their salts as well as to methods for the treatment, amelioration or prevention of conditions that could be treated by inhibiting aldosterone synthetase.

摘要翻译： 本发明涉及式I的三环三唑类似物或其药学上可接受的盐，其中该变量在本文中定义。 本发明化合物选择性地抑制醛固酮合成酶。 本发明还提供包含式I化合物或其盐的药物组合物，以及用于治疗，改善或预防可通过抑制醛固酮合成酶治疗的病症的方法。