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    1-(4-ureidobenzoyl)piperazine derivatives
    1.
    发明授权
    1-(4-ureidobenzoyl)piperazine derivatives 有权
    1-（4-脲基苯甲酰基）哌嗪衍生物

    公开(公告)号：US08759352B2

    公开(公告)日：2014-06-24

    申请号：US13060730

    申请日：2009-08-26

    申请人： Andrew John Cooke ,  David Jonathan Bennett ,  Andrew Stanley Edwards ,  Andrew Laird Roughton ,  Irina Neagu ,  Jui-Hsiang Chan ,  Koc-Kan Ho ,  Nasrin Ansari ,  Michelle Lee Morris ,  Yajing Rong ,  Michael Ohlmeyer

    发明人： Andrew John Cooke ,  David Jonathan Bennett ,  Andrew Stanley Edwards ,  Andrew Laird Roughton ,  Irina Neagu ,  Jui-Hsiang Chan ,  Koc-Kan Ho ,  Nasrin Ansari ,  Michelle Lee Morris ,  Yajing Rong ,  Michael Ohlmeyer

    IPC分类号： A61K31/496 ,  C07D213/56 ,  C07D263/34 ,  C07D277/56 ,  C07D307/68

    CPC分类号： C07D263/34 ,  C07D213/56 ,  C07D277/56 ,  C07D307/68 ,  C07D333/38

    摘要： The present invention relates to 1-(4-ureidobenzoyl)piperazine derivatives having the general Formula I (We bring to your attention that formula I is not provided on this electronic version as it is provided in the abstract of the paper copy) Wherein R1 is (C1-8)alkyl, (C3-8)cycloalkyl or (C3-8)cycloalkyl(C1-3)alkyl, each of which may be substituted by hydroxy, cyano or halogen; R2 represents 1 or 2 optional halogens; R3 is (C1-6)alkyl, (C3-6)cycloalkyl or (C3-6)cycloalkyl(C1-3)alkyl, each of which may be substituted by one or more halogens; A represents a heteroaryl ring system comprising 1-3 heteroatoms selected from N, O and S, which ring system is 5- or 6-membered when X is C, and 5-membered when X is N; n is 1 or 2; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same, and to the use of a these 1-(4-ureidobenzoyl)piperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.

    摘要翻译： 本发明涉及具有通式I的1-（4-脲基苯甲酰基）哌嗪衍生物（我们提请您注意，该电子版本没有提供式I，如在本文摘要中提供的）。其中R1是 （C 1-8）烷基，（C 3-8）环烷基或（C 3-8）环烷基（C 1-3）烷基，其各自可被羟基，氰基或卤素取代; R2表示1或2个任选的卤素; R3是（C 1-6）烷基，（C 3-6）环烷基或（C 3-6）环烷基（C 1-3）烷基，其各自可被一个或多个卤素取代; A表示包含1-3个选自N，O和S的杂原子的杂芳基环系统，当X是C时，该环系统是5-或6-元，当X是N时，该环系是5元; n为1或2; 或其药学上可接受的盐; 涉及包含其的药物组合物，以及这些1-（4-脲基苯甲酰基）哌嗪衍生物在制备用于治疗或预防动脉粥样硬化和与胆汁酸和胆汁酸运输和代谢相关的相关疾病的药物中的用途。

    One-hit tooling for flush mounted rotatable captive nut
    4.
    发明授权
    One-hit tooling for flush mounted rotatable captive nut 有权
    一键式工具，用于嵌入式可旋转固定螺母

    公开(公告)号：US09205520B2

    公开(公告)日：2015-12-08

    申请号：US13348067

    申请日：2012-01-11

    申请人： Andrew John Cooke

    发明人： Andrew John Cooke

    IPC分类号： B23P19/06 ,  F16B37/06

    CPC分类号： B23P19/062 ,  F16B37/062 ,  Y10T29/49908 ,  Y10T29/5343

    摘要： A two-stage punch accomplishes the two-step process of sheet deformation and nut flaring to attach the nut to the sheet in a single stroke of an assembly press. The punch comprises an outer cylindrical sleeve which captivates a resiliently biased center punch. When the punch is moved downward into contact with the sheet, an embossing ring on the sleeve deforms the sheet material around an aperture in the sheet. When the punch is moved farther downward, a pointed end of the center punch extends beyond the embossing ring and into forcible contact with the nut. The nut is thereby flared capturing the sheet between flared edges of the nut and a nut flange.

    摘要翻译： 两级冲头完成片材变形和螺母扩口的两步过程，以在组装压力机的单次冲程中将螺母附接到片材上。 该冲头包括外圆柱形套筒，该外套筒套住弹性偏置的中心冲头。 当冲头向下移动以与片材接触时，套筒上的压花环使片材围绕片材中的孔变形。 当冲头向下移动时，中心冲头的尖端延伸超出压花环并与螺母强制接触。 螺母因此在螺母的扩口边缘和螺母法兰之间张开。