-
公开(公告)号:US20070201614A1
公开(公告)日:2007-08-30
申请号:US11743273
申请日:2007-05-02
申请人: Samuel Goldman , Jeff Chen , Jerry Battista
发明人: Samuel Goldman , Jeff Chen , Jerry Battista
IPC分类号: A61N5/10
CPC分类号: A61N5/1031 , A61N5/1042 , G06F19/00 , G06F19/3481
摘要: Described embodiments relate to improved methods and systems for computationally efficient optimization of radiation dose delivery. The optimization involves determining an improved form of objective function to be used for mapping radiotherapy beams to a patient body volume having at least one target volume and at least one non-target volume. The objective function has a first term related to the at least one target volume and a second term related to the at least one non-target volume. The optimization further involves determining a minimum of the objective function, whereby beams, comprising a plurality of beamlets, mapped to pass through the at least one non-target volume, comprising a plurality of non-target volume portions, are limited such that the second term is zero only if, a product of the intensity of a beamlet mapped to pass through a non-target volume portion and the dose deposited by said beamlet is equal to a first predetermined average dose constraint value for the respective non-target volume portion, for all beamlets mapped to pass through the at least one non-target volume. This limit aims to reduce the occurrence of negative beam weights, thereby facilitating computationally efficient determination of the minimum of the objective function and achieving more physically realistic beamlet intensities. In another embodiment, the objective function has a smoothing term for biasing the intensity of beamlets, for a respective beam mapped to pass through the at least one target volume and the at least non-target volume, towards a uniform distribution within the respective beam. Following the optimization, radiotherapy is delivered based on the determined minimum of the objective function.
摘要翻译: 描述的实施例涉及用于辐射剂量递送的计算上有效优化的改进的方法和系统。 优化包括确定用于将放射治疗束映射到具有至少一个目标体积和至少一个非目标体积的患者体积体积的目标函数的改进形式。 目标函数具有与至少一个目标体积相关的第一项和与该至少一个非目标体相关的第二项。 该优化进一步涉及确定目标函数的最小值,由此包括多个子束的被映射以通过包含多个非目标体积部分的至少一个非目标体积的束被限制,使得第二 只有当映射成通过非目标体积部分的子束的强度的乘积和由所述子束沉积的剂量的乘积等于相应的非目标体积部分的第一预定平均剂量约束值时,术语为零, 对于映射成通过至少一个非目标卷的所有子束。 这个限制旨在减少负光束权重的发生,从而有助于计算有效地确定目标函数的最小值,并实现更加物理上实际的子束强度。 在另一个实施例中,目标函数具有平滑项,用于对于映射成穿过至少一个目标体积和至少非目标体积的相应波束朝向相应波束内的均匀分布来偏置子波束的强度。 优化后,根据所确定的目标函数的最小值进行放射治疗。
-
公开(公告)号:US20070127623A1
公开(公告)日:2007-06-07
申请号:US10581885
申请日:2004-12-10
申请人: Samuel Goldman , Jerry Battista , Jeff Chen
发明人: Samuel Goldman , Jerry Battista , Jeff Chen
IPC分类号: A61N5/10
CPC分类号: A61N5/1031 , A61N5/1042 , G06F19/00 , G06F19/3481
摘要: The invention relates to improved methods and systems for computationally efficient optimization of radiation dose delivery. The optimization involves determining an improved form of objective function to be used for mapping radiotherapy beams to a patient body volume having at least one target volume and at least one non-target volume. The objective function has a first term related to the at least one target volume and a second term related to the at least one non-target volume. The optimization further involves determining a minimum of the objective function, whereby beams mapped so as to pass through the at least one non-target volume are limited such that the second term is zero only if the weights of beamlets passing through the at least one non-target volume are zero. This limit helps to avoid the occurrence of negative beam weights, thereby facilitating computationally efficient determination of the minimum of the objective function using matrix inversion. Following the optimization, radiotherapy is delivered based on the determined minimum of the objective function.
摘要翻译: 本发明涉及用于辐射剂量递送的计算有效优化的改进的方法和系统。 优化包括确定用于将放射治疗束映射到具有至少一个目标体积和至少一个非目标体积的患者体积体积的目标函数的改进形式。 目标函数具有与至少一个目标体积相关的第一项和与该至少一个非目标体相关的第二项。 所述优化进一步涉及确定所述目标函数的最小值,由此映射以便穿过所述至少一个非目标体积的波束被限制,使得仅当通过所述至少一个非目标体积的子束的权重为零时,所述第二项为零, 目标体积为零。 这个限制有助于避免发生负光束权重,从而有助于使用矩阵求逆来计算有效地确定目标函数的最小值。 优化后,根据所确定的目标函数的最小值进行放射治疗。
-