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    METHOD AND SYSTEM FOR OPTIMIZING DOSE DELIVERY OF RADIATION
    1.
    发明申请
    METHOD AND SYSTEM FOR OPTIMIZING DOSE DELIVERY OF RADIATION 失效
    用于优化辐射剂量递送的方法和系统

    公开(公告)号：US20070201614A1

    公开(公告)日：2007-08-30

    申请号：US11743273

    申请日：2007-05-02

    申请人： Samuel Goldman ,  Jeff Chen ,  Jerry Battista

    发明人： Samuel Goldman ,  Jeff Chen ,  Jerry Battista

    IPC分类号： A61N5/10

    CPC分类号： A61N5/1031 ,  A61N5/1042 ,  G06F19/00 ,  G06F19/3481

    摘要： Described embodiments relate to improved methods and systems for computationally efficient optimization of radiation dose delivery. The optimization involves determining an improved form of objective function to be used for mapping radiotherapy beams to a patient body volume having at least one target volume and at least one non-target volume. The objective function has a first term related to the at least one target volume and a second term related to the at least one non-target volume. The optimization further involves determining a minimum of the objective function, whereby beams, comprising a plurality of beamlets, mapped to pass through the at least one non-target volume, comprising a plurality of non-target volume portions, are limited such that the second term is zero only if, a product of the intensity of a beamlet mapped to pass through a non-target volume portion and the dose deposited by said beamlet is equal to a first predetermined average dose constraint value for the respective non-target volume portion, for all beamlets mapped to pass through the at least one non-target volume. This limit aims to reduce the occurrence of negative beam weights, thereby facilitating computationally efficient determination of the minimum of the objective function and achieving more physically realistic beamlet intensities. In another embodiment, the objective function has a smoothing term for biasing the intensity of beamlets, for a respective beam mapped to pass through the at least one target volume and the at least non-target volume, towards a uniform distribution within the respective beam. Following the optimization, radiotherapy is delivered based on the determined minimum of the objective function.

    摘要翻译： 描述的实施例涉及用于辐射剂量递送的计算上有效优化的改进的方法和系统。 优化包括确定用于将放射治疗束映射到具有至少一个目标体积和至少一个非目标体积的患者体积体积的目标函数的改进形式。 目标函数具有与至少一个目标体积相关的第一项和与该至少一个非目标体相关的第二项。 该优化进一步涉及确定目标函数的最小值，由此包括多个子束的被映射以通过包含多个非目标体积部分的至少一个非目标体积的束被限制，使得第二 只有当映射成通过非目标体积部分的子束的强度的乘积和由所述子束沉积的剂量的乘积等于相应的非目标体积部分的第一预定平均剂量约束值时，术语为零， 对于映射成通过至少一个非目标卷的所有子束。 这个限制旨在减少负光束权重的发生，从而有助于计算有效地确定目标函数的最小值，并实现更加物理上实际的子束强度。 在另一个实施例中，目标函数具有平滑项，用于对于映射成穿过至少一个目标体积和至少非目标体积的相应波束朝向相应波束内的均匀分布来偏置子波束的强度。 优化后，根据所确定的目标函数的最小值进行放射治疗。

    Method and system for optimizing dose delivery of radiation
    2.
    发明申请
    Method and system for optimizing dose delivery of radiation 失效
    优化辐射剂量输送的方法和系统

    公开(公告)号：US20070127623A1

    公开(公告)日：2007-06-07

    申请号：US10581885

    申请日：2004-12-10

    申请人： Samuel Goldman ,  Jerry Battista ,  Jeff Chen

    发明人： Samuel Goldman ,  Jerry Battista ,  Jeff Chen

    IPC分类号： A61N5/10

    CPC分类号： A61N5/1031 ,  A61N5/1042 ,  G06F19/00 ,  G06F19/3481

    摘要： The invention relates to improved methods and systems for computationally efficient optimization of radiation dose delivery. The optimization involves determining an improved form of objective function to be used for mapping radiotherapy beams to a patient body volume having at least one target volume and at least one non-target volume. The objective function has a first term related to the at least one target volume and a second term related to the at least one non-target volume. The optimization further involves determining a minimum of the objective function, whereby beams mapped so as to pass through the at least one non-target volume are limited such that the second term is zero only if the weights of beamlets passing through the at least one non-target volume are zero. This limit helps to avoid the occurrence of negative beam weights, thereby facilitating computationally efficient determination of the minimum of the objective function using matrix inversion. Following the optimization, radiotherapy is delivered based on the determined minimum of the objective function.

    摘要翻译： 本发明涉及用于辐射剂量递送的计算有效优化的改进的方法和系统。 优化包括确定用于将放射治疗束映射到具有至少一个目标体积和至少一个非目标体积的患者体积体积的目标函数的改进形式。 目标函数具有与至少一个目标体积相关的第一项和与该至少一个非目标体相关的第二项。 所述优化进一步涉及确定所述目标函数的最小值，由此映射以便穿过所述至少一个非目标体积的波束被限制，使得仅当通过所述至少一个非目标体积的子束的权重为零时，所述第二项为零， 目标体积为零。 这个限制有助于避免发生负光束权重，从而有助于使用矩阵求逆来计算有效地确定目标函数的最小值。 优化后，根据所确定的目标函数的最小值进行放射治疗。

    Use of IL-12 and IL-12 Antagonists in the Treatment of Autoimmune Diseases
    7.
    发明申请
    Use of IL-12 and IL-12 Antagonists in the Treatment of Autoimmune Diseases 审中-公开
    使用IL-12和IL-12拮抗剂治疗自身免疫性疾病

    公开(公告)号：US20130089515A1

    公开(公告)日：2013-04-11

    申请号：US13563009

    申请日：2012-07-31

    申请人： John Leonard ,  Samuel Goldman ,  Richard O'Hara, JR.

    发明人： John Leonard ,  Samuel Goldman ,  Richard O'Hara, JR.

    IPC分类号： A61K39/395 ,  A61K38/20

    CPC分类号： A61K39/3955 ,  A61K38/208 ,  A61K2039/505 ,  C07K16/244 ,  C07K16/249 ,  C07K2317/76 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/903

    摘要： Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-γ or TNF-α. Suitable conditions for treatment include multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes melitis and autoimmune inflammatory eye disease.

    摘要翻译： 公开了治疗自身免疫病症的方法，其包括向哺乳动物受试者IL-12或IL-12拮抗剂施用。 在某些优选实施方案中，自身免疫病症是通过IFN-γ或TNF-α水平升高而促进的。 合适的治疗条件包括多发性硬化，系统性红斑狼疮，类风湿性关节炎，自身免疫性肺部炎症，吉兰巴利综合征，自身免疫性甲状腺炎，胰岛素依赖型糖尿病，自身免疫性炎症性眼病。

    Use of IL-12 antagonists in the treatment of conditions promoted by an increase in levels of IFN-y
    10.
    发明授权
    Use of IL-12 antagonists in the treatment of conditions promoted by an increase in levels of IFN-y 失效
    使用IL-12拮抗剂治疗由IFN-γ水平升高促进的病症

    公开(公告)号：US06706264B1

    公开(公告)日：2004-03-16

    申请号：US09512930

    申请日：2000-02-25

    申请人： John Leonard ,  Samuel Goldman ,  Richard O'Hara, Jr.

    发明人： John Leonard ,  Samuel Goldman ,  Richard O'Hara, Jr.

    IPC分类号： A61K39395

    CPC分类号： A61K39/3955 ,  A61K38/208 ,  A61K2039/505 ,  C07K16/244 ,  C07K16/249 ,  C07K2317/76 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/903

    摘要： Method of treating autoimmune conditions are disclosed comprising administering to a mammalian subject IL-12 or an IL-12 antagonist. In certain preferred embodiments the autoimmune condition is one which is promoted by an increase in levels of IFN-&ggr; or TNF-&agr;. Suitable conditions for treatment include multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, autoimmune pulmonary inflammation, Guillain-Barre syndrome, autoimmune thyroiditis, insulin dependent diabetes melitis and autoimmune inflammatory eye disease.

    摘要翻译： 公开了治疗自身免疫病症的方法，其包括向哺乳动物受试者IL-12或IL-12拮抗剂施用。 在某些优选的实施方案中，自身免疫病症是通过IFN-γ或TNF-α水平升高而促进的。 合适的治疗条件包括多发性硬化，系统性红斑狼疮，类风湿性关节炎，自身免疫性肺部炎症，吉兰巴利综合征，自身免疫性甲状腺炎，胰岛素依赖型糖尿病，自身免疫性炎症性眼病。