Carbapenem antibacterial compositions and methods of the treatment
    2.
    发明授权
    Carbapenem antibacterial compositions and methods of the treatment 失效
    卡巴培南抗菌组合物及治疗方法

    公开(公告)号:US06221859B1

    公开(公告)日:2001-04-24

    申请号:US09387709

    申请日:1999-08-27

    IPC分类号: A61K3143

    摘要: The present invention relates to novel 2-(naphthosultamyl)methyl-carbapenem antibacterial agents or pharmaceutically acceptable salts thereof in combination with other &bgr;-lactams, which are useful in treating and preventing enterococcal infections. The combinations have anti-PBP5 activity as well as activity against the critical PBPs of sensitive isolates. The antibacterial compositions of the present invention thus comprise an important contribution to therapy for treating infections caused by these difficult to control pathogens. This combination is also useful against gram positive microorganisms, especially methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant Staphylococcus epidermidis (MRSE), and methicillin resistant coagulase negative Staphylococci (MRCNS).

    摘要翻译: 本发明涉及新颖的2-(萘磺酰基)甲基 - 碳青霉烯类抗生素或其药学上可接受的盐与其它β-内酰胺的组合,其可用于治疗和预防肠球菌感染。 这些组合具有抗PBP5活性以及针对敏感分离物的关键PBP的活性。 因此,本发明的抗菌组合物对治疗由这些难以控制的病原体引起的感染的治疗具有重要的作用。该组合也可用于革兰氏阳性微生物,特别是耐甲氧西林金黄色葡萄球菌(MRSA),耐甲氧西林葡萄球菌表皮葡萄球菌(MRSE) )和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)。