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公开(公告)号：US4287173A
公开(公告)日：1981-09-01
申请号：US77971
申请日：1979-09-24
IPC分类号： A61K39/09 , A61K20060101 , A61K8/73 , A61K8/99 , A61K31/70 , A61K39/00 , A61K39/02 , A61Q11/00 , A61K7/16
CPC分类号： A61Q11/00 , A61K39/092 , A61K8/73 , A61K8/99
摘要： A vaccine against dental caries is prepared from capsular polysaccharides (one or more strains), of Streptococcus pneumoniae.
摘要翻译： 从荚膜多糖（一种或多种），肺炎链球菌制备抗龋齿疫苗。
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公开(公告)号：US4413057A
公开(公告)日：1983-11-01
申请号：US343305
申请日：1981-03-16
CPC分类号： A61K39/092 , C12P19/26
摘要： Group B Streptococcus type-specific polysaccharides types I.sub.1, I.sub.b, II and III have been obtained from strains grown in a modified soy bean and yeast medium. These polysaccharides are useful as active or passive streptococcal vaccines.
摘要翻译： B族链球菌型特异性多糖类型I1，Ib，II和III已经从在改良大豆和酵母培养基中生长的菌株获得。 这些多糖可用作活性或被动链球菌疫苗。
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3.发明授权
公开(公告)号：US4123520A
公开(公告)日：1978-10-31
申请号：US820665
申请日：1977-08-01
申请人： Arpi Hagopian , Dennis J. Carlo , Thomas H. Stoudt
发明人： Arpi Hagopian , Dennis J. Carlo , Thomas H. Stoudt
IPC分类号： C12P19/04 , A61K39/095 , A61K39/02
CPC分类号： A61K39/095
摘要： A vaccine against Group C meningococcal meningitis consisting of a polysaccharide of which at least 80% by weight has a molecular weight in excess of 1,000,000 daltons is prepared. The polysaccharide was isolated from Group C hexadecyl trimethylammonium bromide cell paste with 1.0M CaCl.sub.2 extraction and purified by phenol extraction, ultracentrifugation at 100,000 g. and ethanol fractionation (30%-45% v/v in ethanol).
摘要翻译： 制备针对C组脑膜炎球菌性脑膜炎的疫苗，其由至少80重量％的分子量超过1,000,000道尔顿的多糖组成。 从C组十六烷基三甲基溴化铵细胞糊中分离多糖，用1.0M CaCl 2萃取，通过苯酚提取纯化，用100,000g超速离心。 和乙醇分馏（30％-45％v / v在乙醇中）。
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4.发明授权High molecular weight meningococcal group C vaccine and method for preparation thereof 失效高分子量脑膜炎球菌C组疫苗及其制备方法
公开(公告)号：US4235994A
公开(公告)日：1980-11-25
申请号：US919359
申请日：1978-06-26
申请人： Thomas H. Stoudt , Dennis J. Carlo , Arpi Hagopian
发明人： Thomas H. Stoudt , Dennis J. Carlo , Arpi Hagopian
IPC分类号： A61K39/095 , C08B37/00
CPC分类号： A61K39/095 , Y10S514/898
摘要： A vaccine against Group C meningococcal meningitis consisting of a polysaccharide of which at least 80% by weight has a molecular weight in excess of 1,000,000 daltons is prepared. The polysaccharide was isolated from Group C hexadecyl trimethylammonium bromide cell paste with 1.0M CaCl.sub.2 extraction and purified by phenol extraction, ultracentrifugation at 100,000 g. and ethanol fractionation (30%-45% v/v in ethanol).
摘要翻译： 制备针对C组脑膜炎球菌性脑膜炎的疫苗，其由至少80重量％的分子量超过1,000,000道尔顿的多糖组成。 从C组十六烷基三甲基溴化铵细胞糊中分离多糖，1.0M CaCl 2萃取，苯酚提取纯化，超速离心10万g。 和乙醇分馏（30％-45％v / v在乙醇中）。
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公开(公告)号：US4362621A
公开(公告)日：1982-12-07
申请号：US258109
申请日：1981-04-27
CPC分类号： G01N1/4077 , B01D63/087 , C12M33/14 , C12M37/02 , G01N33/04
摘要： An improved radial flow cell, comprising two or more sets of inlet port-groove-dam devices for improving the efficiency of radial flows and an efficient filtration device consisting of a micropore membrane and a steel screen support of low retention volume, is useful for aseptic and continuous in-line filtration of heterogeneous mixtures containing high concentrations of solids especially those resulting from fermentation processes.
摘要翻译： 一种改进的径向流动池，包括两组或多组用于提高径向流动效率的入口 - 槽 - 凹槽装置和由微孔膜和低保留体积的钢丝网支撑体组成的有效的过滤装置，可用于无菌 以及连续在线过滤含有高浓度固体的异质混合物，特别是由发酵过程产生的固体。
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公开(公告)号：US4430322A
公开(公告)日：1984-02-07
申请号：US372509
申请日：1982-04-28
CPC分类号： A61K31/715 , A61K8/73 , A61Q11/00 , C12P19/18
摘要： Certain glucans modify the biosynthetic route of extracellular polysaccharides involved in dental plaque development causing critical loss of adhesiveness. They interfere with the biosynthesis of cell-bound polysaccharides reducing and preventing agglutination of cells. They thus aid in the prevention of dental plaque formation or concomitant dental caries and periodontal disease.
摘要翻译： 某些葡聚糖修饰涉及牙斑发育的细胞外多糖的生物合成途径导致粘合性的严重丧失。 它们干扰细胞结合多糖的生物合成，从而减少和预防细胞的凝集。 因此它们有助于预防牙斑形成或伴随的龋齿和牙周病。
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公开(公告)号：US4340673A
公开(公告)日：1982-07-20
申请号：US205030
申请日：1980-11-07
IPC分类号： A61K8/73 , A61K31/715 , A61Q11/00 , C12P19/18 , C12P19/04
CPC分类号： A61K31/715 , A61K8/73 , A61Q11/00 , C12P19/18 , Y10S435/885
摘要： Certain glucans modify the biosynthetic route of extracellular polysaccharides involved in dental plaque development causing critical loss of adhesiveness. They interfere with the biosynthesis of cell-bound polysaccharides reducing and preventing agglutination of cells. They thus aid in the prevention of dental plaque formation or concomitant dental caries and periodontal disease.
摘要翻译： 某些葡聚糖修饰涉及牙斑发育的细胞外多糖的生物合成途径导致粘合性的严重丧失。 它们干扰细胞结合多糖的生物合成，从而减少和预防细胞的凝集。 因此它们有助于预防牙斑形成或伴随的龋齿和牙周病。
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公开(公告)号：US4335101A
公开(公告)日：1982-06-15
申请号：US372137
申请日：1973-06-21
IPC分类号： A23G3/00 , A23G3/36 , A23G4/00 , A23G4/12 , A23L29/00 , A61K8/66 , A61Q11/00 , C12N9/24 , A61K7/28
CPC分类号： A23G3/366 , A23G3/368 , A23G4/123 , A23L29/06 , A61K8/66 , A61Q11/00 , C12N9/2428 , C12Y302/01059 , C12Y302/01071 , C12Y302/01084
摘要： Enzymes called cariogenanases, elaborated by microorganisms are isolated and characterized as polysaccharases capable of degrading cariogenan, a newly discovered glucan of dental plaque composed of .alpha.-(1.fwdarw.3) and .alpha.-(1.fwdarw.2) linkages. The enzymes are isolable from culture broths of various organisms by protein precipitation methods, and have utility as an anti-dental plaque agent, either as the sole enzymatic agent or in combination with dextranases and/or plaque dispersing proteases.
摘要翻译： 由微生物制备的称为致癌物的酶被分离并表征为能够降解由α-（1-> 3）和α-（1-> 2）键组成的牙斑的新近发现的葡聚糖的焦糖的多糖酶。 酶可以通过蛋白质沉淀方法从各种生物的培养液中分离，并且作为唯一的酶剂或与葡聚糖酶和/或斑块分散蛋白酶组合可用作抗牙菌斑剂。
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