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公开(公告)号：US07871981B2
公开(公告)日：2011-01-18
申请号：US11525672
申请日：2006-09-22
申请人： Donald P Bottaro , Alessio Giubellino , Safiye N Atabey , Jesus V Soriano , Diane E Breckenridge , Terrence R Burke, Jr.
发明人： Donald P Bottaro , Alessio Giubellino , Safiye N Atabey , Jesus V Soriano , Diane E Breckenridge , Terrence R Burke, Jr.
CPC分类号： C07K5/0819 , A61K38/05 , A61K38/06 , A61K38/07 , C07K5/0827
摘要： Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. Also disclosed are methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer, for example, melanoma or prostate cancer, comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking blocks HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures.
摘要翻译： 公开了抑制细胞运动性的方法，例如通过抑制细胞内换能器和受体蛋白酪氨酸激酶之间的结合，更具体地通过抑制肝细胞生长因子（HGF）诱导的细胞运动性。 本发明还提供抑制血管发生的方法。 本发明的方法使用诸如磷酸二甲酰基模拟物之类的肽。 还公开了预防和/或治疗诸如癌症，特别是转移性癌症，例如黑素瘤或前列腺癌的疾病，病症，状态或病症的方法，其包括给感兴趣的哺乳动物施用本发明的一种或多种肽。 还公开了阻断HGF，VEGF或bFGF刺激的迁移，细胞增殖和毛细血管样结构的形成的方法。
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2.发明授权Inhibition of cell motility and angiogenesis by inhibitors of Grb2-SH2-domain 有权通过Grb2-SH2结构域抑制剂抑制细胞运动和血管发生公开(公告)号：US07132392B1
公开(公告)日：2006-11-07
申请号：US10111192
申请日：2000-10-20
申请人： Donald P. Bottaro , Safiye N. Atabey , Jesus V. Soriano , Diane E. Breckenridge , Zhu-Jun Yao , Yang Gao , Terrence R. Burke, Jr.
发明人： Donald P. Bottaro , Safiye N. Atabey , Jesus V. Soriano , Diane E. Breckenridge , Zhu-Jun Yao , Yang Gao , Terrence R. Burke, Jr.
CPC分类号： A61K38/07 , A61K38/05 , A61K38/06 , C07K5/0819 , C07K5/0827
摘要： Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. The present invention further provides methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures
摘要翻译： 公开了抑制细胞运动性的方法，例如通过抑制细胞内换能器和受体蛋白酪氨酸激酶之间的结合，更具体地通过抑制肝细胞生长因子（HGF）诱导的细胞运动性。 本发明还提供抑制血管发生的方法。 本发明的方法使用诸如磷酸二甲酰基模拟物之类的肽。 本发明还提供了预防和/或治疗诸如癌症，特别是转移性癌症的疾病，病症，状态或病症的方法，其包括向感兴趣的哺乳动物施用本发明的一种或多种肽。 还公开了阻断HGF，VEGF或bFGF刺激的迁移，细胞增殖和毛细血管样结构的形成的方法
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