公开(公告)号：US07132392B1

公开(公告)日：2006-11-07

申请号：US10111192

申请日：2000-10-20

申请人： Donald P. Bottaro ,  Safiye N. Atabey ,  Jesus V. Soriano ,  Diane E. Breckenridge ,  Zhu-Jun Yao ,  Yang Gao ,  Terrence R. Burke, Jr.

发明人： Donald P. Bottaro ,  Safiye N. Atabey ,  Jesus V. Soriano ,  Diane E. Breckenridge ,  Zhu-Jun Yao ,  Yang Gao ,  Terrence R. Burke, Jr.

IPC分类号： A61K38/08 ,  A61K38/07 ,  A61K38/06 ,  C07K7/04 ,  C07K5/10 ,  C07K5/08

CPC分类号： A61K38/07 ,  A61K38/05 ,  A61K38/06 ,  C07K5/0819 ,  C07K5/0827

摘要： Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. The present invention further provides methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures

摘要翻译： 公开了抑制细胞运动性的方法，例如通过抑制细胞内换能器和受体蛋白酪氨酸激酶之间的结合，更具体地通过抑制肝细胞生长因子（HGF）诱导的细胞运动性。 本发明还提供抑制血管发生的方法。 本发明的方法使用诸如磷酸二甲酰基模拟物之类的肽。 本发明还提供了预防和/或治疗诸如癌症，特别是转移性癌症的疾病，病症，状态或病症的方法，其包括向感兴趣的哺乳动物施用本发明的一种或多种肽。 还公开了阻断HGF，VEGF或bFGF刺激的迁移，细胞增殖和毛细血管样结构的形成的方法