公开(公告)号：US20080118545A1

公开(公告)日：2008-05-22

申请号：US11631094

申请日：2005-06-30

申请人： Tomomichi Futo ,  Kei Mukai ,  Jiichi Arai

发明人： Tomomichi Futo ,  Kei Mukai ,  Jiichi Arai

IPC分类号： A61F2/02 ,  A61K38/08

CPC分类号： A61K38/04 ,  A61K9/0002 ,  A61K9/0019 ,  A61K9/1647 ,  A61K9/5031

摘要： A sustained-release composition which comprises (i) a physiologically active substance and (ii) a lactic acid-glycolic acid copolymer in which the weight-average molecular weight (Mw) is about 8,000 to about 11,500, the ratio of the weight-average molecular weight (Mw) to the number-average molecular weight (Mn) is greater than 1.9, and the compositional molar ratio of lactic acid to glycolic acid is 99.9/0.1 to 60/40, or a salt thereof, and which does not contain a drug retaining substance is provided and said sustained-release composition has improved spherical property and/or needle penetrating property.

摘要翻译： 一种持续释放组合物，其包含（i）生理活性物质和（ii）其中重均分子量（Mw）为约8,000至约11,500的重均分子量（Mw）的乳酸 - 乙醇酸共聚物， 分子量（Mw）与数均分子量（Mn）之比大于1.9，乳酸与乙醇酸的组成摩尔比为99.9 / 0.1〜60/40，或其盐，不含 提供药物保留物质，所述持续释放组合物具有改善的球形性和/或针穿透性。

公开(公告)号：US20050064039A1

公开(公告)日：2005-03-24

申请号：US10498215

申请日：2002-12-25

申请人： Tomomichi Futo ,  Kazumichi Yamamoto ,  Jiichi Arai

发明人： Tomomichi Futo ,  Kazumichi Yamamoto ,  Jiichi Arai

IPC分类号： A61K9/16 ,  A61K9/52 ,  A61P13/00 ,  A61P13/08 ,  A61P35/00 ,  B01J13/12 ,  A61K9/50 ,  B01J13/02 ,  B01J13/04

CPC分类号： A61K9/1647 ,  B01J13/12

摘要： A provision of a method for producing a microsphere improved in dispersibility. A method for producing a microsphere improved in dispersibility, characterized in that during the production of microspheres by an in-water drying method, an osmotic pressure regulating agent is added to an outer water phase.

摘要翻译： 提供一种提高分散性的微球的制造方法。 一种提高分散性的微球的制造方法，其特征在于，在通过水中干燥法制造微球时，将渗透压调节剂添加到外层水相中。

公开(公告)号：US06371941B1

公开(公告)日：2002-04-16

申请号：US09150768

申请日：1998-09-10

申请人： Masahiko Kato ,  Jiichi Arai ,  Makoto Kakiuti

发明人： Masahiko Kato ,  Jiichi Arai ,  Makoto Kakiuti

IPC分类号： A61M5315

CPC分类号： A61M5/284 ,  A61M2005/31508

摘要： A prefilled syringe has a tubular body which has an open front end and an open rear end. A front assembly is mounted on an outer periphery of a front end portion of the tubular body. A finger grip is mounted on an outer periphery of a rear end portion of the tubular body. A front sealing member is provided in the tubular body so as to be disposed forwardly of injection liquid and a rear sealing member is provided in the tubular body so as to be disposed rearwards of the injection liquid. A plunger rod is provided so as to be movable in the tubular body. A temporary stop member temporarily stops the plunger rod through retention of the temporary stop member by the finger grip such that the rear sealing member is temporarily stopped at a predetermined position of the tubular body. A retention canceling member cancels the retention of the temporary stop member by the finger grip without moving the plunger rod.

摘要翻译： 预充式注射器具有管状体，其具有敞开的前端和敞开的后端。 前组件安装在管状体的前端部的外周上。 手指把手安装在管状体的后端部分的外周上。 一个前密封件设置在管状体中，以便设置在注射液体的前方，并且后密封件设置在管状体中，以便设置在喷射液体的后方。 柱塞杆设置成能够在管状体中移动。 临时停止构件通过手指握住临时停止构件的暂时停止柱塞杆，使得后密封构件暂时停在管状体的预定位置。 保持取消构件通过手指抓住暂时停止构件的保持而不移动柱塞杆。