公开(公告)号：US20220065876A1

公开(公告)日：2022-03-03

申请号：US17523113

申请日：2021-11-10

申请人： Jim Connolly

发明人： Jim Connolly

IPC分类号： G01N33/72 ,  A61B5/15 ,  A61B5/145

摘要： Electrochemical test sensors and analysis methods are described that reduce or eliminate the pre-treatment or dilution of blood samples prior to HbA1c analysis. Thus, a blood sample obtained from a blood draw or phlebotomy may be introduced to the electrochemical test sensor for HbA1c analysis. The described test sensors immobilize or deactivate incompatible reagents, enzymes, and antibodies so they do not substantially interfere with each other during the analysis. The test sensors also use heat to catalyze reactions that otherwise would proceed at too slow of a rate to be practical.

公开(公告)号：US20210310980A1

公开(公告)日：2021-10-07

申请号：US17350410

申请日：2021-06-17

申请人： Jim Connolly

发明人： Jim Connolly

IPC分类号： G01N27/327 ,  C12Q1/00 ,  B01L7/00

摘要： A test sensor heating system is disclosed that provides the desired and different temperatures to at least two different reaction zones based on a fixed potential. The measurement device does not alter the potential applied to the heating system in response to temperature feedback information. The heating system provides the desired and different temperatures to the different reaction zones of the test sensor by varying heating element spacing and/or the resistivity of an associated resistive layer of the test sensor to provide the desired temperature in response to the fixed potential. The system also may provide two or more different temperature zones to the test sensor by using different heating element spacing and/or resistive layer resistivity at different locations of the test sensor.

公开(公告)号：US11079351B2

公开(公告)日：2021-08-03

申请号：US16194489

申请日：2018-11-19

申请人： Jim Connolly

发明人： Jim Connolly

IPC分类号： G01N27/327 ,  C12Q1/00

摘要： Immobilization zones through which a sample flows before reaching the proteolytic agents and/or active enzyme and associated electrode/s of an electrochemical test sensor may be used to trap or chemically deactivate active enzyme and/or proteolytic agent deactivating agents. Through either trapping or chemical deactivation, the immobilization zones substantially prevent the enzyme deactivating agents from reaching, and thus reducing the activity of the active enzyme or enzymes. Similarly, trapping or chemical deactivation may be used to prevent or substantially reduce the incidence of the proteolytic deactivating agent or agents from reaching the proteolytic agent.

公开(公告)号：US20190154619A1

公开(公告)日：2019-05-23

申请号：US16196547

申请日：2018-11-20

申请人： Jim Connolly

发明人： Jim Connolly

IPC分类号： G01N27/327 ,  C12Q1/00

摘要： A test sensor heating system is disclosed that provides the desired and different temperatures to at least two different reaction zones based on a fixed potential. The measurement device does not alter the potential applied to the heating system in response to temperature feedback information. The heating system provides the desired and different temperatures to the different reaction zones of the test sensor by varying heating element spacing and/or the resistivity of an associated resistive layer of the test sensor to provide the desired temperature in response to the fixed potential. The system also may provide two or more different temperature zones to the test sensor by using different heating element spacing and/or resistive layer resistivity at different locations of the test sensor.

公开(公告)号：US12044649B2

公开(公告)日：2024-07-23

申请号：US17350410

申请日：2021-06-17

申请人： Jim Connolly

发明人： Jim Connolly

IPC分类号： G01N27/327 ,  B01L7/00 ,  C12Q1/00

CPC分类号： G01N27/3272 ,  B01L7/54 ,  C12Q1/001 ,  G01N27/327 ,  G01N27/3273 ,  B01L2300/0645 ,  B01L2300/0887 ,  B01L2300/1827

摘要： A test sensor heating system is disclosed that provides the desired and different temperatures to at least two different reaction zones based on a fixed potential. The measurement device does not alter the potential applied to the heating system in response to temperature feedback information. The heating system provides the desired and different temperatures to the different reaction zones of the test sensor by varying heating element spacing and/or the resistivity of an associated resistive layer of the test sensor to provide the desired temperature in response to the fixed potential. The system also may provide two or more different temperature zones to the test sensor by using different heating element spacing and/or resistive layer resistivity at different locations of the test sensor.

公开(公告)号：US20190317039A1

公开(公告)日：2019-10-17

申请号：US16194489

申请日：2018-11-19

申请人： Jim Connolly

发明人： Jim Connolly

IPC分类号： G01N27/327 ,  C12Q1/00

摘要： Immobilization zones through which a sample flows before reaching the proteolytic agents and/or active enzyme and associated electrode/s of an electrochemical test sensor may be used to trap or chemically deactivate active enzyme and/or proteolytic agent deactivating agents. Through either trapping or chemical deactivation, the immobilization zones substantially prevent the enzyme deactivating agents from reaching, and thus reducing the activity of the active enzyme or enzymes. Similarly, trapping or chemical deactivation may be used to prevent or substantially reduce the incidence of the proteolytic deactivating agent or agents from reaching the proteolytic agent.

公开(公告)号：US11199551B1

公开(公告)日：2021-12-14

申请号：US15820611

申请日：2017-11-22

申请人： Jim Connolly

发明人： Jim Connolly

IPC分类号： G01N33/72 ,  A61B5/145 ,  A61B5/15

摘要： Electrochemical test sensors and analysis methods are described that reduce or eliminate the pre-treatment or dilution of blood samples prior to HbA1c analysis. Thus, a blood sample obtained from a blood draw or phlebotomy may be introduced to the electrochemical test sensor for HbA1c analysis. The described test sensors immobilize or deactivate incompatible reagents, enzymes, and antibodies so they do not substantially interfere with each other during the analysis. The test sensors also use heat to catalyze reactions that otherwise would proceed at too slow of a rate to be practical.

公开(公告)号：US11067529B2

公开(公告)日：2021-07-20

申请号：US16196547

申请日：2018-11-20

申请人： Jim Connolly

发明人： Jim Connolly

IPC分类号： G01N27/327 ,  C12Q1/00 ,  B01L7/00

摘要： A test sensor heating system is disclosed that provides the desired and different temperatures to at least two different reaction zones based on a fixed potential. The measurement device does not alter the potential applied to the heating system in response to temperature feedback information. The heating system provides the desired and different temperatures to the different reaction zones of the test sensor by varying heating element spacing and/or the resistivity of an associated resistive layer of the test sensor to provide the desired temperature in response to the fixed potential. The system also may provide two or more different temperature zones to the test sensor by using different heating element spacing and/or resistive layer resistivity at different locations of the test sensor.

公开(公告)号：US08469861B1

公开(公告)日：2013-06-25

申请号：US12499568

申请日：2009-07-08

申请人： Susan L. McFee ,  Rodney L. Wickwar ,  Jim Connolly

发明人： Susan L. McFee ,  Rodney L. Wickwar ,  Jim Connolly

IPC分类号： A63B71/00 ,  A63B24/00 ,  A63B21/005

CPC分类号： A63B21/0058 ,  A63B21/0054 ,  A63B21/0059 ,  A63B21/4035 ,  A63B23/03583 ,  A63B69/0028 ,  A63B71/0619 ,  A63B71/0686 ,  A63B2071/0691 ,  A63B2210/50 ,  A63B2220/12 ,  A63B2220/18 ,  A63B2220/20 ,  A63B2220/30 ,  A63B2220/806 ,  A63B2220/807 ,  A63B2220/808 ,  A63B2225/09 ,  A63B2225/15 ,  A63B2225/50 ,  A63B2225/682 ,  A63B2230/06 ,  A63B2230/75

摘要： A pushable exercise apparatus configured to be pushed along a surface by a user and to provide user-selected variation in resistance to rotation applied to wheels of the apparatus. The apparatus may comprise a frame, a handle, a wheel shaft rotatably supported by the frame, one or more wheels fixedly attached to the wheel shaft, and an electrical braking system, such as a generator braking system. The electrical braking system may have a motor driven by rotation of the wheel shaft and variable electrical resistance such that an amount of torque and/or effort required to rotate at least one of the wheels is dependant on the amount of electrical resistance provided to the motor.

摘要翻译： 一种被推送的锻炼设备，其构造成沿着使用者沿表面推动并且提供用户选择的抵抗装置的轮子的旋转阻力变化。 该装置可以包括框架，手柄，由框架可旋转地支撑的轮轴，固定地附接到轮轴的一个或多个车轮，以及诸如发电机制动系统的电气制动系统。 电气制动系统可以具有由轮轴的旋转驱动的电动机和可变电阻，使得旋转至少一个车轮所需的扭矩和/或力量的数量取决于提供给电动机的电阻量 。