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1.发明申请CHROMATOGRAPHY LIGAND COMPRISING DOMAIN C FROM STAPHYLOCOCCUS AUREUS PROTEIN A FOR ANTIBODY ISOLATION 有权含有葡萄球菌蛋白A的抗体分离体的C区的色谱配体公开(公告)号：US20120289680A1
公开(公告)日：2012-11-15
申请号：US13559663
申请日：2012-07-27
申请人： MARTIN HALL , STURE LARSSON , ANDREAS MURANYI , GUSTAV RODRIGO , JINYU ZOU , PER-MIKAEL ÅBERG
发明人： MARTIN HALL , STURE LARSSON , ANDREAS MURANYI , GUSTAV RODRIGO , JINYU ZOU , PER-MIKAEL ÅBERG
CPC分类号： B01J20/24 , B01D15/3809 , B01J20/28019 , B01J20/285 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3293 , B01J2220/52 , B01J2220/54 , C07K1/22 , C07K14/31 , C07K16/00 , C07K17/00 , C07K17/10 , C07K2317/55
摘要： The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates to a process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.
摘要翻译： 本发明涉及一种色谱配体，其包含来自葡萄球菌蛋白A（SpA）的结构域C，或其功能片段或变体。 色谱配体具有在现场（CIP）条件下耐受苛刻清洁的有利能力，并且能够结合抗体的Fab片段。 配体可以具有末端偶联基团，例如精氨酸或半胱氨酸，以促进其与不溶性载体例如珠粒或膜的偶联。 本发明还涉及在分离抗体中使用配体的方法以及可以包括洗涤步骤和/或用碱再生的纯化方案。
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![[1, 2, 4] TRIAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS CHROMATOGRAPHIC ADSORBENT FOR THE SELECTIVE ADSORPTION OF IGG](/abs-image/US/2009/10/15/US20090259029A1/abs.jpg.150x150.jpg)
2.发明申请[1, 2, 4] TRIAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS CHROMATOGRAPHIC ADSORBENT FOR THE SELECTIVE ADSORPTION OF IGG 有权[1,2,4]三唑并[1,5-A]吡嗪衍生物作为选择性吸附IGG的色谱吸附剂公开(公告)号：US20090259029A1
公开(公告)日：2009-10-15
申请号：US12486155
申请日：2009-06-17
申请人： MATHIAS ALTERMAN , Andreas Axen , Enrique Carredano , Anna Gronberg , Jinyu Zou
发明人： MATHIAS ALTERMAN , Andreas Axen , Enrique Carredano , Anna Gronberg , Jinyu Zou
IPC分类号： C07K1/22
CPC分类号： B01J20/3255 , B01D15/3804 , B01J20/286 , B01J20/289 , B01J20/3219 , B01J20/3242 , B01J20/3244 , C07D487/04
摘要： The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula and its corresponding enol-form, wherein X represents O, S, or NH; R1 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, Ar, —C(O)NHR3, —C(O)—R3 or halo; R2 represents H, C1-3 alkyl or halo; R3 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.
摘要翻译： 本发明涉及用于选择性吸附IgG的色谱吸附剂，其包含下式及其相应的烯醇式，其中X代表O，S或NH; R 1表示H，C 1-6烷基，C 1-6烷氧基，C 1-6烷氧基-C 1-6烷基，Ar，-C（O）NHR 3，-C（O）-R 3或卤素; R 2表示H，C 1-3烷基或卤素; R 3表示H，C 1-6烷基，C 1-6烷氧基，C 1-6烷氧基-C 1-6烷基或Ar; n表示0,1,2或3; Y表示载体。 本发明还涉及生产所述吸附剂的方法及其通过亲和层析分离物质的用途。
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3.发明授权Chromatography ligand comprising domain C from staphylococcus aureus protein A for antibody isolation 有权色谱配体包含来自金黄色葡萄球菌蛋白A的结构域C用于抗体分离公开(公告)号：US08772447B2
公开(公告)日：2014-07-08
申请号：US13559663
申请日：2012-07-27
申请人： Martin Hall , Sture Larsson , Andreas Muranyi , Gustav Rodrigo , Jinyu Zou , Per-Mikael Aberg
发明人： Martin Hall , Sture Larsson , Andreas Muranyi , Gustav Rodrigo , Jinyu Zou , Per-Mikael Aberg
IPC分类号： C07K17/00
CPC分类号： B01J20/24 , B01D15/3809 , B01J20/28019 , B01J20/285 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3293 , B01J2220/52 , B01J2220/54 , C07K1/22 , C07K14/31 , C07K16/00 , C07K17/00 , C07K17/10 , C07K2317/55
摘要： The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates to a process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.
摘要翻译： 本发明涉及一种色谱配体，其包含来自葡萄球菌蛋白A（SpA）的结构域C，或其功能片段或变体。 色谱配体具有在现场（CIP）条件下耐受苛刻清洁的有利能力，并且能够结合抗体的Fab片段。 配体可以具有末端偶联基团，例如精氨酸或半胱氨酸，以促进其与不溶性载体例如珠粒或膜的偶联。 本发明还涉及在分离抗体中使用配体的方法以及可以包括洗涤步骤和/或用碱再生的纯化方案。
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![[1, 2, 4] Triazolo [1, 5-A] Pyrimidine Derivatives as Chromatographic Adsorbent for the Selective Adsorption of Igg](/abs-image/US/2008/09/11/US20080220968A1/abs.jpg.150x150.jpg)
4.发明申请[1, 2, 4] Triazolo [1, 5-A] Pyrimidine Derivatives as Chromatographic Adsorbent for the Selective Adsorption of Igg 审中-公开[1,2,4]三氮唑[1,5-A]嘧啶衍生物作为IgG选择性吸附的色谱吸附剂公开(公告)号：US20080220968A1
公开(公告)日：2008-09-11
申请号：US11994145
申请日：2006-06-26
申请人： Mathias Alterman , Axen Andreas , Enrique Carredano , Anna Gronberg , Jinyu Zou
发明人： Mathias Alterman , Axen Andreas , Enrique Carredano , Anna Gronberg , Jinyu Zou
CPC分类号： B01J20/3255 , B01D15/3804 , B01J20/286 , B01J20/289 , B01J20/3219 , B01J20/3242 , B01J20/3244 , C07D487/04
摘要： The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula and its corresponding enol-form, wherein X represents O, S, or NH; R1 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, Ar, —C(O)NHR3, —C(O)—R3 or halo; R2 represents H, C1-3 alkyl or halo; R3 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.
摘要翻译： 本发明涉及用于选择性吸附IgG的色谱吸附剂，其包含下式及其相应的烯醇式，其中X代表O，S或NH; R 1表示H，C 1-6烷基，C 1-6 - 烷氧基，C 1-6 - 烷氧基 -C 1-6烷基，Ar，-C（O）NHR 3，-C（O）-R 3或卤素; R 2表示H，C 1-3烷基或卤素; R 3表示H，C 1-6烷基，C 1-6烷氧基，C 1-6 - 烷氧基 -C 1-6烷基或Ar; n表示0,1,2或3; Y表示载体。 本发明还涉及生产所述吸附剂的方法及其通过亲和层析分离物质的用途。
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5.发明授权Chromatography ligand comprising domain C from Staphylococcus aureus protein A for antibody isolation 有权包含来自金黄色葡萄球菌蛋白A的结构域C的色谱配体用于抗体分离公开(公告)号：US08329860B2
公开(公告)日：2012-12-11
申请号：US12443011
申请日：2007-09-27
申请人： Martin Hall , Sture Larsson , Andreas Muranyi , Gustav Rodrigo , Jinyu Zou , Per-Mikael Aberg
发明人： Martin Hall , Sture Larsson , Andreas Muranyi , Gustav Rodrigo , Jinyu Zou , Per-Mikael Aberg
IPC分类号： C07K17/00
CPC分类号： B01J20/24 , B01D15/3809 , B01J20/28019 , B01J20/285 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3293 , B01J2220/52 , B01J2220/54 , C07K1/22 , C07K14/31 , C07K16/00 , C07K17/00 , C07K17/10 , C07K2317/55
摘要： The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates to a process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.
摘要翻译： 本发明涉及一种色谱配体，其包含来自葡萄球菌蛋白A（SpA）的结构域C，或其功能片段或变体。 色谱配体具有在现场（CIP）条件下耐受苛刻清洁的有利能力，并且能够结合抗体的Fab片段。 配体可以具有末端偶联基团，例如精氨酸或半胱氨酸，以促进其与不溶性载体例如珠粒或膜的偶联。 本发明还涉及在分离抗体中使用配体的方法以及可以包括洗涤步骤和/或用碱再生的纯化方案。
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6.发明申请CHROMATOGRAPHY LIGAND COMPRISING DOMAIN C FROM STAPHYLOCOCCUS AUREUS PROTEIN A FOR ANTIBODY ISOLATION 有权含有葡萄球菌蛋白A的抗体分离体的C区的色谱配体公开(公告)号：US20100048876A1
公开(公告)日：2010-02-25
申请号：US12443011
申请日：2007-09-27
申请人： Martin Hall , Sture Larsson , Andreas Muranyi , Gustav Rodrigo , Jinyu Zou , Per-Mikael Aberg
发明人： Martin Hall , Sture Larsson , Andreas Muranyi , Gustav Rodrigo , Jinyu Zou , Per-Mikael Aberg
CPC分类号： B01J20/24 , B01D15/3809 , B01J20/28019 , B01J20/285 , B01J20/286 , B01J20/289 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/3293 , B01J2220/52 , B01J2220/54 , C07K1/22 , C07K14/31 , C07K16/00 , C07K17/00 , C07K17/10 , C07K2317/55
摘要： The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates to a process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.
摘要翻译： 本发明涉及一种色谱配体，其包含来自葡萄球菌蛋白A（SpA）的结构域C，或其功能片段或变体。 色谱配体具有在现场（CIP）条件下耐受苛刻清洁的有利能力，并且能够结合抗体的Fab片段。 配体可以具有末端偶联基团，例如精氨酸或半胱氨酸，以促进其与不溶性载体例如珠粒或膜的偶联。 本发明还涉及在分离抗体中使用配体的方法以及可以包括洗涤步骤和/或用碱再生的纯化方案。
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![[1, 2, 4] Triazolo [1, 5-A] pyrimidine derivatives as chromatographic adsorbent for the selective adsorption of IGG](/abs-image/US/2009/12/01/US07625838B2/abs.jpg.150x150.jpg)
7.发明授权[1, 2, 4] Triazolo [1, 5-A] pyrimidine derivatives as chromatographic adsorbent for the selective adsorption of IGG 有权[1,2,4]三氮唑[1,5-A]嘧啶衍生物作为选择性吸附IGG的色谱吸附剂公开(公告)号：US07625838B2
公开(公告)日：2009-12-01
申请号：US12486155
申请日：2009-06-17
申请人： Mathias Alterman , Andreas Axen , Enrique Carredano , Anna Gronberg , Jinyu Zou
发明人： Mathias Alterman , Andreas Axen , Enrique Carredano , Anna Gronberg , Jinyu Zou
CPC分类号： B01J20/3255 , B01D15/3804 , B01J20/286 , B01J20/289 , B01J20/3219 , B01J20/3242 , B01J20/3244 , C07D487/04
摘要： The present invention relates to a chromatographic adsorbent for selectively adsorbing IgG, comprising the following formula and its corresponding enol-form, wherein X represents O, S, or NH; R1 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl, Ar, —C(O)NHR3, —C(O)—R3 or halo; R2 represents H, C1-3 alkyl or halo; R3 represents H, C1-6 alkyl, C1-6 alkoxy, C1-6 alkoxy-C1-6 alkyl or Ar; n represents 0, 1, 2 or 3; Y represents a carrier. The present invention also relates to a method of producing said adsorbent as well as use thereof for separating substances by affinity chromatography.
摘要翻译： 本发明涉及用于选择性吸附IgG的色谱吸附剂，其包含下式及其相应的烯醇式，其中X代表O，S或NH; R 1表示H，C 1-6烷基，C 1-6烷氧基，C 1-6烷氧基-C 1-6烷基，Ar，-C（O）NHR 3，-C（O）-R 3或卤素; R 2表示H，C 1-3烷基或卤素; R 3表示H，C 1-6烷基，C 1-6烷氧基，C 1-6烷氧基-C 1-6烷基或Ar; n表示0,1,2或3; Y表示载体。 本发明还涉及生产所述吸附剂的方法及其通过亲和层析分离物质的用途。
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