公开(公告)号：US12083500B2

公开(公告)日：2024-09-10

申请号：US17230082

申请日：2021-04-14

申请人： Mitsubishi Chemical Corporation

发明人： Tadashi Adachi

IPC分类号： B01J20/285 ,  A23L27/30 ,  B01D15/42 ,  B01J20/26 ,  B01J20/28 ,  C07J17/00

CPC分类号： B01J20/285 ,  A23L27/36 ,  B01D15/424 ,  B01J20/262 ,  B01J20/267 ,  B01J20/28016 ,  B01J20/2808 ,  B01J20/28083 ,  B01J20/28085 ,  C07J17/005 ,  A23V2002/00 ,  B01J2220/52

摘要： An object of the present invention is to provide a separation medium and a separation method, ensuring high selectivity and good separation efficiency for specific steviol glycosides. The present invention is related to a separation medium in which polyethyleneimine is immobilized to porous particles of a (meth)acrylic polymer having a crosslinked structure and a hydroxyl group.

公开(公告)号：US20240157335A1

公开(公告)日：2024-05-16

申请号：US18282491

申请日：2022-03-09

申请人： W.R. Grace & Co.-Conn.

发明人： Keling ZHANG ,  Reno NGUYEN ,  Simon THOMAS

IPC分类号： B01J20/287 ,  B01D15/32 ,  B01J20/10 ,  B01J20/28 ,  B01J20/32 ,  C07C37/82 ,  C07D311/80

CPC分类号： B01J20/287 ,  B01D15/325 ,  B01J20/103 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/28061 ,  B01J20/28083 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3259 ,  B01J20/3293 ,  C07C37/82 ,  C07D311/80 ,  B01J2220/52

摘要： A stationary phase for high-performance liquid chromatography including monofunctional primary silane functionalized silica provides improved separation performance for the preparative or process scale purification of cannabidiol (CBD) and tetrahydro-cannabinol (THC). Silica bonded with monofunctional primary silane(s) provides more efficient separation of these molecules through higher resolution values, reduced peak broadening and lower separation impedance, thus enabling higher purity product or more efficient purification process.

公开(公告)号：US11925918B2

公开(公告)日：2024-03-12

申请号：US16831548

申请日：2020-03-26

申请人： CANON KABUSHIKI KAISHA

发明人： Kengo Kanazaki ,  Fumio Yamauchi ,  Teigo Sakakibara ,  Yoshinori Kotani ,  Ryoko Ueyama

IPC分类号： B01J20/10 ,  B01D15/14 ,  B01J20/08 ,  B01J20/24 ,  B01J20/28 ,  B01J20/283 ,  B01J20/286 ,  B01J20/30 ,  B09B3/10 ,  B09B101/30 ,  C01B33/18 ,  C02F1/28 ,  C02F101/20 ,  C02F103/08 ,  C22B11/00 ,  G21F9/12

CPC分类号： B01J20/103 ,  B01D15/14 ,  B01J20/08 ,  B01J20/24 ,  B01J20/28007 ,  B01J20/28016 ,  B01J20/2803 ,  B01J20/28052 ,  B01J20/283 ,  B01J20/286 ,  B01J20/3028 ,  B01J20/3085 ,  B09B3/10 ,  C01B33/18 ,  C02F1/281 ,  C02F1/286 ,  C02F1/288 ,  C22B11/042 ,  B01J2220/52 ,  B01J2220/58 ,  B09B2101/30 ,  C01P2004/50 ,  C01P2004/61 ,  C01P2004/64 ,  C02F2101/20 ,  C02F2103/08 ,  G21F9/12

摘要： A silica aggregate includes primary silica particles aggregated, the primary silica particles having an average particle size of 1 nm or more and less than 10 nm, the primary silica particles being crosslinked to each other by a bond containing a siloxane bond.

公开(公告)号：US11925879B2

公开(公告)日：2024-03-12

申请号：US16894679

申请日：2020-06-05

申请人： BATTELLE MEMORIAL INSTITUTE

发明人： Matthew J. O'Hara

IPC分类号： B01D15/20 ,  B01D15/18 ,  B01J20/10 ,  B01J20/26 ,  B01J20/28 ,  B01J20/283 ,  B01J20/285 ,  B01J20/34 ,  C01G21/00 ,  C01G29/00 ,  C22B3/42 ,  C22B26/20 ,  G21G1/00

CPC分类号： B01D15/203 ,  B01D15/1871 ,  B01J20/103 ,  B01J20/261 ,  B01J20/28004 ,  B01J20/28016 ,  B01J20/283 ,  B01J20/285 ,  B01J20/3425 ,  B01J20/3433 ,  B01J20/3475 ,  C01G21/003 ,  C01G29/003 ,  C22B3/42 ,  C22B26/20 ,  G21G1/001 ,  B01J2220/52 ,  B01J2220/603

摘要： Methods for separating Ra from Pb, Bi, and Th are provided, the methods can include: providing a first mixture comprising Ra, Pb, Bi, and/or Th; providing a system that can include: a first vessel housing a first media; a second vessel in fluid communication with the first vessel, the second vessel housing a second media; and a third vessel in fluid communication with the second vessel, the third vessel housing a third media; and exposing the first mixture to the first media within the first vessel then, through the fluid communication, exposing the first remainder to the second media in the second vessel, then, through fluid communication, exposing the next remainder to the third media in the third vessel, the exposing separating the Th and Bi from the Ra and Pb, and the Ra from the Pb. Methods for separating Ra from being associated with a media are also provided. The methods can include: exposing the Ra and media to a chelating agent to form a mixture comprising the Ra complexed with the chelating agent.

公开(公告)号：US20240003858A1

公开(公告)日：2024-01-04

申请号：US18250911

申请日：2021-10-29

申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

发明人： Michael R. Van Dam ,  Travis S. Holloway ,  Alejandra Rios ,  Chelsea Okoro

IPC分类号： G01N30/95 ,  B01J20/28 ,  B01J20/34 ,  B01D15/42

CPC分类号： G01N30/95 ,  B01J20/28035 ,  B01J20/3475 ,  B01D15/426 ,  B01J2220/52 ,  B01J2220/49

摘要： A method of purifying radiochemical species (e.g., radiopharmaceuticals) using thin layer chromatography (TLC) plates includes loading one or more TLC plates with a sample containing the radiochemical species to be purified. The one or more TLC plates are then developed with a mobile phase. The one or more developed TLC plates are then imaged to obtain radioactivity image(s) of the one or more TLC plates. Optional UV images may also be obtained using the same imaging platform. The location of the radiochemical species on the one or more TLC plates is identified from the radioactivity image(s). The radiochemical species on the one or more TLC plates is/are removed at the identified locations. Removal may be accomplished using a mechanical process such as scraping or punching. Alternatively, non-destructive techniques may be employed to remove the radiochemical species from the TLC plate(s).

公开(公告)号：US20230347316A1

公开(公告)日：2023-11-02

申请号：US17981262

申请日：2022-11-04

申请人： Cytiva Bioprocess R&D AB

发明人： Martin HALL ,  Sture LARSSON ,  Andreas MURANYI ,  Gustav RODRIGO ,  Jinyu ZOU ,  Per-Mikael ABERG

IPC分类号： B01J20/24 ,  B01D15/38 ,  B01J20/286 ,  C07K1/22 ,  B01J20/32 ,  C07K14/31 ,  C07K16/00 ,  C07K17/00 ,  B01J20/28 ,  B01J20/285 ,  B01J20/289 ,  C07K17/10

CPC分类号： B01J20/24 ,  B01D15/3809 ,  B01J20/286 ,  C07K1/22 ,  B01J20/3274 ,  C07K14/31 ,  C07K16/00 ,  C07K17/00 ,  B01J20/28019 ,  B01J20/285 ,  B01J20/289 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3293 ,  C07K17/10 ,  C07K2317/55 ,  B01J2220/52 ,  B01J2220/54

摘要： The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates to a process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.

公开(公告)号：US11801489B2

公开(公告)日：2023-10-31

申请号：US17215110

申请日：2021-03-29

申请人： Joseph F. Krebs

发明人： Joseph F. Krebs

IPC分类号： B01J20/29 ,  B01J20/291 ,  B01J20/24 ,  B01J20/26 ,  B01J20/28 ,  C07K1/16 ,  B01D15/34

CPC分类号： B01J20/291 ,  B01D15/34 ,  B01J20/24 ,  B01J20/261 ,  B01J20/262 ,  B01J20/28016 ,  B01J20/28047 ,  B01J20/28052 ,  C07K1/16 ,  B01J2220/52

摘要： A separation medium for removing small molecules from biomacromolecule in aqueous mixtures comprises gel filtration chromatography beads having a nominal protein fractional range of about 1000 Da to about 5000 Da and having an internal adsorbent matrix derived from a hydrophobicized scaffold. The gel filtration chromatography beads remove small molecules that are less than 1500 Da and have log Pow values greater than about −0.5 from biomacromolecules in aqueous mixtures. Devices containing the separation medium are also provided.

公开(公告)号：US20230294068A1

公开(公告)日：2023-09-21

申请号：US18200096

申请日：2023-05-22

申请人： HOYA CORPORATION

发明人： Shintaro KOBAYASHI

IPC分类号： B01J20/04 ,  B01J20/28 ,  B01J20/282 ,  B01J20/30 ,  B01J20/281 ,  C01B25/32

CPC分类号： B01J20/048 ,  B01J20/28004 ,  B01J20/28057 ,  B01J20/28011 ,  B01J20/2803 ,  B01J20/28069 ,  B01J20/28078 ,  B01J20/282 ,  B01J20/3078 ,  B01J20/28016 ,  B01J20/28059 ,  B01J20/281 ,  B01J20/3021 ,  B01J20/3028 ,  B01J20/3085 ,  C01B25/322 ,  C01B25/327 ,  Y10T428/2982 ,  B01J2220/56 ,  B01J2220/54 ,  B01J20/28019 ,  B01J2220/52 ,  C01P2004/53 ,  C01P2004/61 ,  C01P2006/12

摘要： The present invention provides that powder is mainly constituted from secondary particles of hydroxyapatite. The secondary particles are obtained by drying a slurry containing primary particles of hydroxyapatite and aggregates thereof and granulating the primary particles and the aggregates. A bulk density of the powder is 0.65 g/mL or more and a specific surface area of the secondary particles is 70 m2/g or more. The powder of the present invention has high strength and is capable of exhibiting superior adsorption capability when it is used for an adsorbent an adsorption apparatus has.

公开(公告)号：US11753438B2

公开(公告)日：2023-09-12

申请号：US16095753

申请日：2017-05-10

申请人： CYTIVA BIOPROCESS R&D AB

发明人： Annika Forss ,  Gustav José Rodrigo ,  Tomas Bjorkman ,  Mats Ander ,  Jesper Ulf Hansson

IPC分类号： C07K1/22 ,  B01J20/26 ,  B01J20/285 ,  B01J20/286 ,  B01J20/32 ,  C07K14/31 ,  C07K16/00 ,  C07K16/12 ,  C07K17/10

CPC分类号： C07K1/22 ,  B01J20/267 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3274 ,  C07K14/31 ,  C07K16/00 ,  C07K16/1271 ,  C07K17/10 ,  B01J2220/52

摘要： The present invention concerns a method of cleaning and/or sanitizing a separation matrix comprising multimers of immunoglobulin-binding alkali-stabilized Protein A domains covalently coupled to a porous support. The method comprises the steps of: a) optionally purifying a mixture comprising a first immunoglobulin using the separation matrix; b) providing a cleaning liquid comprising at least 50% by volume of an aqueous alkali metal hydroxide solution; and c) cleaning and/or sanitizing the separation matrix by contacting the cleaning liquid with the separation matrix for a predetermined contact time. The alkali-stabilized Protein A domains comprise mutants of a parental Fc-binding domain of Staphylococcus Protein A (SpA), as defined by SEQ ID NO 51 or SEQ ID NO 52, wherein the amino acid residues at positions 13 and 44 of SEQ ID NO 51 or 52 are asparagines and wherein at least the asparagine residue at position 3 of SEQ ID NO 51 or 52 has been mutated to an amino acid selected from the group consisting of glutamic acid, lysine, tyrosine, threonine, phenylalanine, leucine, isoleucine, tryptophan, methionine, valine, alanine, histidine and arginine.

公开(公告)号：US20170341058A1

公开(公告)日：2017-11-30

申请号：US15544414

申请日：2016-01-19

申请人： Hitachi Chemical Company, LTD.

发明人： Masaru WATANABE ,  Tomoko HIGASHIUCHI ,  Fumihiko KAWAUCHI ,  Yasushi GOTOH ,  Michio BUTSUGAN

IPC分类号： B01J20/32 ,  B01J20/24 ,  B01J20/26 ,  B01J20/28 ,  B01J20/285 ,  C07K1/18 ,  B01J41/14 ,  B01D15/36 ,  B01J20/30 ,  B01J20/281 ,  C08J7/04

CPC分类号： B01J20/3282 ,  B01D15/361 ,  B01J20/24 ,  B01J20/267 ,  B01J20/28016 ,  B01J20/28052 ,  B01J20/285 ,  B01J20/3085 ,  B01J20/321 ,  B01J20/3217 ,  B01J20/3293 ,  B01J41/14 ,  B01J2220/445 ,  B01J2220/52 ,  C07K1/16 ,  C07K1/18 ,  C08J7/047 ,  C08J2325/02 ,  C08J2405/12 ,  G01N30/482 ,  G01N30/88

摘要： The present invention provides a separation material comprising porous polymer particles that comprise a styrene-based monomer as a monomer unit; and a coating layer that comprises a macromolecule having hydroxyl groups and covers at least a portion of the surface of the porous polymer particles, wherein the rupture strength is 10 mN or higher.