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    METHOD FOR HIGH SPATIAL RESOLUTION EXAMINATION OF A SAMPLE STRUCTURE LABELED WITH A SUBSTANCE
    1.
    发明申请
    METHOD FOR HIGH SPATIAL RESOLUTION EXAMINATION OF A SAMPLE STRUCTURE LABELED WITH A SUBSTANCE 审中-公开
    用于物质标记的样品结构的高空间分辨率检查方法

    公开(公告)号：US20100124788A1

    公开(公告)日：2010-05-20

    申请号：US12620107

    申请日：2009-11-17

    申请人： Jochen Sieber

    发明人： Jochen Sieber

    IPC分类号： G01N21/76

    CPC分类号： G01N33/542 ,  B82Y15/00 ,  G01N33/585 ,  G01N33/68

    摘要： A method for high spatial resolution examination of a sample structure includes providing a biological structure as the sample structure with a substance capable of being converted from a first state to a second state. The first and second states of the substance differ in at least one photophysical property. The sample structure is labeled by binding a suitable protein tag including a fluorogen activating protein (FAP) to the sample structure or by expressing the protein tag and the sample structure together as a fusion protein. Then the protein tag is bound to the substance.

    摘要翻译： 用于样品结构的高空间分辨率检查的方法包括提供具有能够从第一状态转换为第二状态的物质的生物结构作为样品结构。 该物质的第一和第二种状态在至少一种光物理性质上不同。 通过将包含荧光激活蛋白（FAP）的合适的蛋白质标签与样品结构结合或通过将蛋白质标签和样品结构一起表达为融合蛋白来标记样品结构。 然后蛋白质标签与物质结合。

    Method for high spatial resolution stochastic examination of a sample structure labeled with a substance
    2.
    发明授权
    Method for high spatial resolution stochastic examination of a sample structure labeled with a substance 有权
    用物质标记的样品结构的高空间分辨率随机检验方法

    公开(公告)号：US08293490B2

    公开(公告)日：2012-10-23

    申请号：US12632639

    申请日：2009-12-07

    申请人： Volker Seyfried ,  Jochen Sieber

    发明人： Volker Seyfried ,  Jochen Sieber

    IPC分类号： G01N33/53 ,  G01N31/00

    CPC分类号： G01N21/6428 ,  G01N21/6458

    摘要： A method for high spatial resolution stochastic examination of a biological sample structure labeled with a labeling substance is described. The method comprises providing a biological sample structure; choosing such a labeling substance that has molecules present in a first state and in a second state, and the first and second states differ from one another in at least one photophysical property such that there is sufficient probability that one portion of the molecules of the substance will be in the first state and another portion of the molecules will be in the second state and within which labeling substance a change of the state of the molecules can occur spontaneously between the two states in both directions; and labeling the biological sample structure with the substance.

    摘要翻译： 描述了用标记物质标记的生物样品结构的高空间分辨率随机检查方法。 该方法包括提供生物样品结构; 选择具有以第一状态和第二状态存在的分子的这种标记物质，并且第一和第二状态在至少一种光物理性质上彼此不同，使得物质分子的一部分有足够的可能性 将处于第一状态，并且分子的另一部分将处于第二状态，并且标记物质内的分子状态的变化可以在两个方向的两个状态之间自发地发生; 并用物质标记生物样品结构。

    METHOD FOR HIGH SPATIAL RESOLUTION STOCHASTIC EXAMINATION OF A SAMPLE STRUCTURE LABELED WITH A SUBSTANCE
    4.
    发明申请
    METHOD FOR HIGH SPATIAL RESOLUTION STOCHASTIC EXAMINATION OF A SAMPLE STRUCTURE LABELED WITH A SUBSTANCE 有权
    用于物质标记的样品结构的高空间分辨率STOCHASTIC检验方法

    公开(公告)号：US20100160613A1

    公开(公告)日：2010-06-24

    申请号：US12632639

    申请日：2009-12-07

    申请人： Volker Seyfried ,  Jochen Sieber

    发明人： Volker Seyfried ,  Jochen Sieber

    IPC分类号： C07K1/13

    CPC分类号： G01N21/6428 ,  G01N21/6458

    摘要： A method for high spatial resolution stochastic examination of a biological sample structure labeled with a labeling substance is described. The method comprises providing a biological sample structure; choosing such a labeling substance that has molecules present in a first state and in a second state, and the first and second states differ from one another in at least one photophysical property such that there is sufficient probability that one portion of the molecules of the substance will be in the first state and another portion of the molecules will be in the second state and within which labeling substance a change of the state of the molecules can occur spontaneously between the two states in both directions; and labeling the biological sample structure with the substance.

    摘要翻译： 描述了用标记物质标记的生物样品结构的高空间分辨率随机检查方法。 该方法包括提供生物样品结构; 选择具有以第一状态和第二状态存在的分子的这种标记物质，并且第一和第二状态在至少一种光物理性质上彼此不同，使得物质分子的一部分有足够的可能性 将处于第一状态，并且分子的另一部分将处于第二状态，并且标记物质内的分子状态的变化可以在两个方向的两个状态之间自发地发生; 并用物质标记生物样品结构。

    DEVICE AND METHOD FOR PROVIDING A PREDETERMINABLE CONCENTRATION OF AT LEAST ONE COMPONENT IN A LIQUID MEDIUM
    5.
    发明申请
    DEVICE AND METHOD FOR PROVIDING A PREDETERMINABLE CONCENTRATION OF AT LEAST ONE COMPONENT IN A LIQUID MEDIUM 有权
    用于提供液体介质中至少一个组分的可预测浓度的装置和方法

    公开(公告)号：US20100122588A1

    公开(公告)日：2010-05-20

    申请号：US12617049

    申请日：2009-11-12

    申请人： Jochen Sieber ,  Marcus Dyba ,  Volker Seyfried

    发明人： Jochen Sieber ,  Marcus Dyba ,  Volker Seyfried

    IPC分类号： G01N1/14 ,  B01L3/02

    CPC分类号： G01N1/38 ,  G01N1/10 ,  G01N21/64 ,  G01N35/1097 ,  G05D11/138

    摘要： A method and a device for providing a predeterminable concentration of at least one component in a microscopic sample liquid medium are described. The device includes a feeding device for the at least one component. Measurement data are determined, measuring a predeterminable parameter using a microscopic method. The concentration of the at least one component is adjusted or controlled via the feeding device based on the basis of measurement data.

    摘要翻译： 描述了在微观样品液体介质中提供至少一种组分的可预定浓度的方法和装置。 该装置包括用于至少一个部件的进给装置。 确定测量数据，使用微观方法测量可预定参数。 基于测量数据的基础，通过进给装置调节或控制至少一个部件的浓度。