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公开(公告)号：US08137922B2
公开(公告)日：2012-03-20
申请号：US12676528
申请日：2008-09-04
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/76 , G01N2800/04
摘要： The present invention discloses a method for diagnosing the metabolic syndrome by determination of the afamin content in a sample of a body fluid or a tissue sample, wherein the metabolic syndrome is diagnosed if the afamin content in the sample is increased compared to the afamin content in a sample from a person not having the metabolic syndrome.
摘要翻译： 本发明公开了一种用于通过测定体液或组织样品的样品中的尿素含量来诊断代谢综合征的方法，其中如果样品中的微量蛋白质含量相比于所述代谢综合征中的尿素含量增加，则代谢综合征被诊断 来自不具有代谢综合征的人的样品。
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2.发明申请Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis and methods of detecting FSAP and FSAP mutations 有权因子VII激活蛋白酶（FSAP）的Marburg I突变体作为动脉血栓形成的危险因素，以及检测FSAP和FSAP突变的方法公开(公告)号：US20070099229A1
公开(公告)日：2007-05-03
申请号：US11633501
申请日：2006-12-05
申请人： Stefan Kiechl , Johann Willeit , Christian Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
发明人： Stefan Kiechl , Johann Willeit , Christian Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
IPC分类号： C12Q1/68 , G01N33/567 , C12N9/64
CPC分类号： C12N9/6424 , C12N9/6421 , C12N9/647 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N33/6893 , G01N33/86 , G01N2800/323
摘要： A novel arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII-activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described.
摘要翻译： 描述了包含一种或多种所鉴定的凝血因子VII活化蛋白酶（FSAP）的突变体的新型动脉血栓形成危险因素。 此外，描述了用于检测被鉴定为危险因素的这些突变体的诊断测定方法。
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3.发明授权Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis 有权因子VII激活蛋白酶（FSAP）的Marburg I突变体作为动脉血栓形成的危险因素公开(公告)号：US07153679B2
公开(公告)日：2006-12-26
申请号：US10391215
申请日：2003-03-19
申请人： Stefan Kiechl , Johann Willeit , Christian Josef Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
发明人： Stefan Kiechl , Johann Willeit , Christian Josef Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
CPC分类号： C12N9/6424 , C12N9/6421 , C12N9/647 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N33/6893 , G01N33/86 , G01N2800/323
摘要： A novel arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII-activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described.
摘要翻译： 描述了包含一种或多种所鉴定的凝血因子VII活化蛋白酶（FSAP）的突变体的新型动脉血栓形成危险因素。 此外，描述了用于检测被鉴定为危险因素的这些突变体的诊断测定方法。
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公开(公告)号：US20100260771A1
公开(公告)日：2010-10-14
申请号：US12676528
申请日：2008-09-04
IPC分类号： A61K39/395 , G01N33/68 , C12Q1/02 , G01N33/53 , A61K38/00 , A61K31/713 , A61P3/00
CPC分类号： G01N33/6893 , G01N2333/76 , G01N2800/04
摘要： The present invention discloses a method for diagnosing the metabolic syndrome by determination of the afamin content in a sample of a body fluid or a tissue sample, wherein the metabolic syndrome is diagnosed if the afamin content in the sample is increased compared to the afamin content in a sample from a person not having the metabolic syndrome.
摘要翻译： 本发明公开了一种用于通过测定体液或组织样品的样品中的尿素含量来诊断代谢综合征的方法，其中如果样品中的微量蛋白质含量相比于所述代谢综合征中的尿素含量增加，则代谢综合征被诊断 来自不具有代谢综合征的人的样品。
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5.发明授权Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis and methods of detecting FSAP and FSAP mutations 有权因子VII激活蛋白酶（FSAP）的Marburg I突变体作为动脉血栓形成的危险因素，以及检测FSAP和FSAP突变的方法公开(公告)号：US07803569B2
公开(公告)日：2010-09-28
申请号：US11633501
申请日：2006-12-05
申请人： Stefan Kiechl , Johann Willeit , Christian Josef Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
发明人： Stefan Kiechl , Johann Willeit , Christian Josef Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
CPC分类号： C12N9/6424 , C12N9/6421 , C12N9/647 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N33/6893 , G01N33/86 , G01N2800/323
摘要： An arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described.
摘要翻译： 描述了包含一种或多种所鉴定的凝血因子VII活化蛋白酶（FSAP）突变体的动脉血栓形成危险因素。 此外，描述了用于检测被鉴定为危险因素的这些突变体的诊断测定方法。
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