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1.发明授权Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis and methods of detecting FSAP and FSAP mutations 有权因子VII激活蛋白酶（FSAP）的Marburg I突变体作为动脉血栓形成的危险因素，以及检测FSAP和FSAP突变的方法公开(公告)号：US07803569B2
公开(公告)日：2010-09-28
申请号：US11633501
申请日：2006-12-05
申请人： Stefan Kiechl , Johann Willeit , Christian Josef Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
发明人： Stefan Kiechl , Johann Willeit , Christian Josef Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
CPC分类号： C12N9/6424 , C12N9/6421 , C12N9/647 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N33/6893 , G01N33/86 , G01N2800/323
摘要： An arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described.
摘要翻译： 描述了包含一种或多种所鉴定的凝血因子VII活化蛋白酶（FSAP）突变体的动脉血栓形成危险因素。 此外，描述了用于检测被鉴定为危险因素的这些突变体的诊断测定方法。
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2.发明授权Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis 有权因子VII激活蛋白酶（FSAP）的Marburg I突变体作为动脉血栓形成的危险因素公开(公告)号：US07153679B2
公开(公告)日：2006-12-26
申请号：US10391215
申请日：2003-03-19
申请人： Stefan Kiechl , Johann Willeit , Christian Josef Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
发明人： Stefan Kiechl , Johann Willeit , Christian Josef Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
CPC分类号： C12N9/6424 , C12N9/6421 , C12N9/647 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N33/6893 , G01N33/86 , G01N2800/323
摘要： A novel arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII-activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described.
摘要翻译： 描述了包含一种或多种所鉴定的凝血因子VII活化蛋白酶（FSAP）的突变体的新型动脉血栓形成危险因素。 此外，描述了用于检测被鉴定为危险因素的这些突变体的诊断测定方法。
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3.发明申请Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis and methods of detecting FSAP and FSAP mutations 有权因子VII激活蛋白酶（FSAP）的Marburg I突变体作为动脉血栓形成的危险因素，以及检测FSAP和FSAP突变的方法公开(公告)号：US20070099229A1
公开(公告)日：2007-05-03
申请号：US11633501
申请日：2006-12-05
申请人： Stefan Kiechl , Johann Willeit , Christian Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
发明人： Stefan Kiechl , Johann Willeit , Christian Wiedermann , Juergen Roemisch , Thomas Weimer , Annette Feussner , Hans-Arnold Stoehr , Volker Doersam , Wiegand Lang , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
IPC分类号： C12Q1/68 , G01N33/567 , C12N9/64
CPC分类号： C12N9/6424 , C12N9/6421 , C12N9/647 , C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , G01N33/6893 , G01N33/86 , G01N2800/323
摘要： A novel arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII-activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are described.
摘要翻译： 描述了包含一种或多种所鉴定的凝血因子VII活化蛋白酶（FSAP）的突变体的新型动脉血栓形成危险因素。 此外，描述了用于检测被鉴定为危险因素的这些突变体的诊断测定方法。
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4.发明授权Mutants of the factor VII-activating protease and detection methods using specific antibodies 有权因子VII活化蛋白酶的突变体和使用特异性抗体的检测方法公开(公告)号：US07863009B2
公开(公告)日：2011-01-04
申请号：US12232350
申请日：2008-09-16
申请人： Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
发明人： Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
IPC分类号： G01N33/53
CPC分类号： C12N9/647 , A61K38/00 , C07K16/40 , C12N9/6424 , G01N33/86 , G01N2333/96463
摘要： Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
摘要翻译： 编码激活血液凝固因子VII和单链纤溶酶原激活物的蛋白酶（FSAP）的DNA序列的突变体，在核苷酸位置1177处包含G / C碱基交换的突变体和/或核苷酸位置处的G / A碱基交换 1601。 相应的蛋白酶在氨基酸位置393处具有Glu / Gln交换和/或氨基酸位置534处的Gly / Glu交换。用于检测体液或组织细胞中的FSAP的诊断方法以及用于鉴定具有遗传杂合的患者 或纯合的FSAP表达也被描述。 另外，公开了针对FSAP及其突变体的抗体，并且可以用于检测针对FSAP及其突变体的抗体的诊断方法。
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5.发明申请Mutants of the factor VII-activating protease and detection methods using specific antibodies 有权因子VII活化蛋白酶的突变体和使用特异性抗体的检测方法公开(公告)号：US20090162871A1
公开(公告)日：2009-06-25
申请号：US12232350
申请日：2008-09-16
申请人： Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
发明人： Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
IPC分类号： G01N33/573
CPC分类号： C12N9/647 , A61K38/00 , C07K16/40 , C12N9/6424 , G01N33/86 , G01N2333/96463
摘要： Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
摘要翻译： 编码激活血液凝固因子VII和单链纤溶酶原激活物的蛋白酶（FSAP）的DNA序列的突变体，在核苷酸位置1177处包含G / C碱基交换的突变体和/或核苷酸位置处的G / A碱基交换 1601。 相应的蛋白酶在氨基酸位置393处具有Glu / Gln交换和/或氨基酸位置534处的Gly / Glu交换。用于检测体液或组织细胞中的FSAP的诊断方法以及用于鉴定具有遗传杂合的患者 或纯合的FSAP表达也被描述。 另外，公开了针对FSAP及其突变体的抗体，并且可以用于检测针对FSAP及其突变体的抗体的诊断方法。
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6.发明授权Mutants of the factor VII-activating protease and detection methods using specific antibodies 有权因子VII活化蛋白酶的突变体和使用特异性抗体的检测方法公开(公告)号：US07442514B2
公开(公告)日：2008-10-28
申请号：US10930754
申请日：2004-09-01
申请人： Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
发明人： Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
IPC分类号： G01N33/53
CPC分类号： C12N9/647 , A61K38/00 , C07K16/40 , C12N9/6424 , G01N33/86 , G01N2333/96463
摘要： Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
摘要翻译： 编码激活血液凝固因子VII和单链纤溶酶原激活物的蛋白酶（FSAP）的DNA序列的突变体，在核苷酸位置1177处包含G / C碱基交换的突变体和/或核苷酸位置处的G / A碱基交换 1601。 相应的蛋白酶在氨基酸位置393处具有Glu / Gln交换和/或氨基酸位置534处的Gly / Glu交换。用于检测体液或组织细胞中的FSAP的诊断方法以及用于鉴定具有遗传杂合的患者 或纯合的FSAP表达也被描述。 另外，公开了针对FSAP及其突变体的抗体，并且可以用于检测针对FSAP及其突变体的抗体的诊断方法。
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7.发明申请Mutants of the factor VII-activating protease and detection methods using specific antibodies 有权因子VII活化蛋白酶的突变体和使用特异性抗体的检测方法公开(公告)号：US20050032109A1
公开(公告)日：2005-02-10
申请号：US10930754
申请日：2004-09-01
申请人： Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
发明人： Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann , Bernd Knoblauch
IPC分类号： G01N33/53 , C07K16/40 , C12N9/50 , C12N9/64 , C12N15/09 , C12N15/57 , C12P21/08 , C12Q1/56 , C12Q1/68 , G01N33/533 , G01N33/534 , G01N33/535 , C07H21/04 , C07K14/755 , C12P21/04
CPC分类号： C12N9/647 , A61K38/00 , C07K16/40 , C12N9/6424 , G01N33/86 , G01N2333/96463
摘要： Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutant comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, is described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Furthermore, diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
摘要翻译： 编码激活血液凝固因子VII和单链纤溶酶原激活物的蛋白酶（FSAP）的DNA序列的突变体，其在核苷酸位置1177处包含G / C碱基交换和/或在核苷酸位置处的G / A碱基交换 1601。 相应的蛋白酶在氨基酸位置393处具有Glu / Gln交换和/或氨基酸位置534处的Gly / Glu交换。此外，用于检测体液或组织细胞中的FSAP的诊断方法以及用于鉴定患有 描述了遗传杂合或纯合FSAP表达。 另外，公开了针对FSAP及其突变体的抗体，并且可以用于检测针对FSAP及其突变体的抗体的诊断方法。
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8.发明授权Mutants of the factor VII-activating protease and detection methods using specific antibodies 失效因子VII活化蛋白酶的突变体和使用特异性抗体的检测方法公开(公告)号：US06831167B2
公开(公告)日：2004-12-14
申请号：US09912559
申请日：2001-07-26
申请人： Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann
发明人： Juergen Roemisch , Hans-Arnold Stoehr , Annette Feussner , Wiegand Lang , Thomas Weimer , Margret Becker , Claudia Nerlich , Gudrun Muth-Naumann
IPC分类号： C07H2104
CPC分类号： C12N9/647 , A61K38/00 , C07K16/40 , C12N9/6424 , G01N33/86 , G01N2333/96463
摘要： Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 1601, are described. The corresponding protease has a Glu/Gln exchange at amino acid position 393 and/or a Gly/Glu exchange at amino acid position 534. Diagnostic methods which are used for detecting FSAP in body fluids or tissue cells and also for identifying patients with genetic heterozygous or homozygous FSAP expression are also described. In addition, antibodies against FSAP and its mutants are disclosed and diagnostic methods which can be used to detect antibodies against FSAP and its mutants are specified.
摘要翻译： 编码激活血液凝固因子VII和单链纤溶酶原激活物的蛋白酶（FSAP）的DNA序列的突变体，在核苷酸位置1177处包含G / C碱基交换的突变体和/或核苷酸位置处的G / A碱基交换 1601。 相应的蛋白酶在氨基酸位置393处具有Glu / Gln交换和/或氨基酸位置534处的Gly / Glu交换。用于检测体液或组织细胞中的FSAP的诊断方法以及用于鉴定具有遗传杂合的患者 或纯合的FSAP表达也被描述。 另外，公开了针对FSAP及其突变体的抗体，并且可以用于检测针对FSAP及其突变体的抗体的诊断方法。
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9.发明授权Inhibitory monoclonal antibody against blood clotting factor VII-activating protease 有权抗凝血因子Ⅶ活化蛋白酶的抑制性单克隆抗体公开(公告)号：US07829095B2
公开(公告)日：2010-11-09
申请号：US10359704
申请日：2003-02-07
申请人： Juergen Roemisch , Wiegand Lang , Annette Feussner , Gudrun Muth-Naumann , Hans-Arnold Stoehr , Christian Kannemaier , Klaus Preissner , Fumie Nakazawa
发明人： Juergen Roemisch , Wiegand Lang , Annette Feussner , Gudrun Muth-Naumann , Hans-Arnold Stoehr , Christian Kannemaier , Klaus Preissner , Fumie Nakazawa
IPC分类号： A61K39/395
CPC分类号： C12N9/6424 , A61K47/6871 , A61K2039/505 , C07K16/40 , C12N9/6437 , C12Q1/37 , C12Y304/21021 , G01N33/86 , G01N2333/96447
摘要： A monoclonal antibody which inhibits the blood clotting factor VII-activating protease and its proenzyme and a blood clotting factor VII-activating protease, stabilized by the addition of said monoclonal antibody, and its proenzyme are described. A suitable monoclonal antibody is produced by hybridoma cell line DSM ACC 2533. The application of the inhibitory, monoclonal antibody in the stabilization of blood clotting preparations and in preparations for reducing the coagulability of the blood is disclosed.
摘要翻译： 描述了抑制通过添加所述单克隆抗体稳定的血液凝固因子VII活化蛋白酶及其酶原和血液凝固因子VII活化蛋白酶的单克隆抗体及其酶原。 通过杂交瘤细胞系DSM ACC 2533产生合适的单克隆抗体。公开了抑制性单克隆抗体在血液凝固制剂的稳定化和降低血液凝固性的制剂中的应用。
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10.发明授权Monoclonal antibody which is specific for activated coagulation factor VII, and its use 失效活化凝血因子VII特异的单克隆抗体及其用途公开(公告)号：US06835817B2
公开(公告)日：2004-12-28
申请号：US10226118
申请日：2002-08-23
申请人： Jürgen Römisch , Wiegand Lang , Annette Feussner , Joachim Röder
发明人： Jürgen Römisch , Wiegand Lang , Annette Feussner , Joachim Röder
IPC分类号： C07K1600
CPC分类号： C12N9/6437 , A61K38/00 , C07K16/40 , C07K2317/24 , C12Y304/21021
摘要： A monoclonal antibody has been developed which only specifically binds activated factor VII, and not factor VII, and which does not bind to an activated factor VII which is complexed with antithrombin III. This monoclonal antibody is isolated from the hybridoma cell line DSM ACC 2332. It can be used for qualitatively and quantitatively detecting factor VIIa in body fluids, blood coagulation preparations or the intermediate stages in the production of these preparations, on cell surfaces or in tissues, and can also be used as a humanized monoclonal antibody in therapeutic preparations.
摘要翻译： 已经开发了单克隆抗体，其仅特异性结合活化因子VII而不是因子VII，并且不结合与抗凝血酶III复合的活化因子VII。 该单克隆抗体从杂交瘤细胞系DSM ACC 2332中分离出来。它可用于定性和定量检测体液，血液凝固制剂或这些制剂的生产中的中间阶段，细胞表面或组织中的VIIa因子， 并且也可以用作治疗制剂中的人源化单克隆抗体。
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