公开(公告)号：US20080154145A1

公开(公告)日：2008-06-26

申请号：US12008349

申请日：2008-01-10

申请人： Malcolm Howard Wilkinson ,  Clive Andrew Ramsden ,  Philip John Berger

发明人： Malcolm Howard Wilkinson ,  Clive Andrew Ramsden ,  Philip John Berger

IPC分类号： A61B5/08

CPC分类号： A61B5/4818 ,  A61B5/08 ,  A61B8/08

摘要： The present invention relates to a method of determining characteristics of biological tissues in humans and animals. In particular, it relates to determining the characteristics of tissues such as the lungs and airways by introducing a sound to the tissue, and recording the sound. The invention further includes an apparatus capable of such measurement. In a first aspect of the present invention there is provided a method of determining characteristics of biological tissue in situ, including: introducing a sound to the tissue at first position; detecting the sound at another position spaced from the first position after it has traveled through the tissue; calculating the velocity and attenuation of sound that has traveled through the tissue from the first position to another position; and correlating the velocity and attenuation of the detected sound to characteristics of the biological tissue.

摘要翻译： 本发明涉及一种确定人和动物生物组织特征的方法。 特别涉及通过向组织引入声音并记录声音来确定诸如肺和气道的组织的特征。 本发明还包括能够进行这种测量的装置。 在本发明的第一方面，提供了一种确定生物组织的特征的方法，包括：在第一位置向所述组织引入声音; 在其已经穿过组织后检测与第一位置间隔开的另一位置处的声音; 计算已经穿过组织从第一位置到另一位置的声音的速度和衰减; 并将检测到的声音的速度和衰减与生物组织的特征相关联。

公开(公告)号：US07347824B2

公开(公告)日：2008-03-25

申请号：US10272494

申请日：2002-10-15

申请人： Malcolm Howard Wilkinson ,  Clive Andrew Ramsden ,  Philip John Berger

发明人： Malcolm Howard Wilkinson ,  Clive Andrew Ramsden ,  Philip John Berger

IPC分类号： A61B5/08

CPC分类号： A61B5/4818 ,  A61B5/08 ,  A61B8/08

摘要： The present invention relates to a method of determining characteristics of biological tissues in humans and animals. In particular, it relates to determining the characteristics of tissues such as the lungs and airways by introducing a sound to the tissue, and recording the sound. The invention further includes an apparatus capable of such measurement. In a first aspect of the present invention there is provided a method of determining characteristics of biological tissue in situ, including: introducing a sound to the tissue at first position; detecting the sound at another position spaced from the first position after it has traveled through the tissue; calculating the velocity and attenuation of sound that has traveled through the tissue from the first position to another position; and correlating the velocity and attenuation of the detected sound to characteristics of the biological tissue.

公开(公告)号：US20060151122A1

公开(公告)日：2006-07-13

申请号：US11035139

申请日：2005-01-13

申请人： Billy Hines ,  Frank Beaty ,  Glen Smith ,  John Berger ,  Marshall Smith

发明人： Billy Hines ,  Frank Beaty ,  Glen Smith ,  John Berger ,  Marshall Smith

IPC分类号： B01D7/00 ,  B01D1/00

CPC分类号： F17C7/00 ,  F17C7/04 ,  G21C21/02 ,  G21Y2002/201 ,  G21Y2002/202 ,  G21Y2002/304 ,  G21Y2004/30 ,  G21Y2004/40

摘要： A method of operating a vaporization system including a first cylinder, a second cylinder, and an eductor having a suction inlet, a motive inlet, and an outlet is provided. The method includes vaporizing uranium hexaflouride in the first cylinder, channeling the vaporized uranium hexaflouride in the first cylinder to the suction inlet of the eductor, monitoring the pressure of the vaporized uranium hexaflouride channeled to the suction inlet, and channeling the vaporized uranium hexaflouride through the outlet. The method also includes vaporizing uranium hexaflouride in the second cylinder, and channeling the vaporized uranium hexaflouride in the second cylinder to the motive inlet of the eductor when the flow of uranium hexaflouride channeled to the suction inlet is below a predetermined amount.

摘要翻译： 提供一种操作包括具有吸入口，动力入口和出口的第一气缸，第二气缸和喷射器的汽化系统的方法。 该方法包括在第一气缸中蒸发六氟化铀，将第一气缸中的蒸发的六氟化铀引导至喷射器的吸入口，监测通向吸入口的蒸发的六氟化铀的压力，并将蒸发的六氟化铀通过 出口。 该方法还包括在第二气缸中蒸发铀六氟化物，并且当引导到吸入口的六氟化铀流低于预定量时，将第二气缸中的蒸发的六氟化铀引导至喷射器的动力入口。

公开(公告)号：US06844451B2

公开(公告)日：2005-01-18

申请号：US10615346

申请日：2003-07-07

申请人： Dirk Lichtblau ,  Nina Berova ,  John Berger ,  Koji Nakanishi

发明人： Dirk Lichtblau ,  Nina Berova ,  John Berger ,  Koji Nakanishi

IPC分类号： A61K31/365 ,  A61K36/00 ,  A61K36/16 ,  C07D307/77 ,  C07D493/14 ,  C07D307/93

CPC分类号： C07D307/77 ,  A61K31/365 ,  A61K36/16

摘要： A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an acceptable extraction agent; separating the organic layer from the aqueous layer; washing the organic layer with an acceptable aqueous salt or hydroxide solution, which may be an alkaline solution; and drying the organic layer to form a dried extract containing terpene trilactones. Further purification by treatment with or filtration over activated charcoal, by treatment with or filtration over alumina and by recrystallization with an acceptable solvent or solvent mixture leads to extracts with a content of terpene trilactones higher than 50%. Unwanted levels of ginkgolic acids are reduced to acceptable levels by reversed phase chromatography.

摘要翻译： 从银杏植物材料或提取物中分离萜品三内酯的方法，包括将植物材料或提取物悬浮在水或氧化试剂的水溶液中的步骤; 使用可接受的提取剂萃取萜烯三内酯; 从水层分离有机层; 用可接受的盐或氢氧化物溶液洗涤有机层，其可以是碱性溶液; 并干燥有机层以形成含有萜烯三内酯的干燥提取物。 通过用活性炭处理或过滤进一步纯化，通过在氧化铝上处理或过滤，并用可接受的溶剂或溶剂混合物重结晶，得到萜烯三内酯的含量高于50％的提取物。 不需要的银杏酸水平通过反相色谱法降至可接受的水平。

公开(公告)号：US20140068033A1

公开(公告)日：2014-03-06

申请号：US13604289

申请日：2012-09-05

申请人： John Berger ,  Daniel Gibson ,  Allen Kirby ,  Wayne Lappe ,  Curtis Rugeley ,  David Wicks ,  Karen Swisher ,  David Leitson

发明人： John Berger ,  Daniel Gibson ,  Allen Kirby ,  Wayne Lappe ,  Curtis Rugeley ,  David Wicks ,  Karen Swisher ,  David Leitson

IPC分类号： H04L12/24

CPC分类号： H04L41/0813 ,  H04L41/0681 ,  H04L41/069 ,  H04L41/0816 ,  H04L41/0846 ,  H04L41/0893 ,  H04L43/16

摘要： Systems, methods, and articles of manufacture to manage alarm configurations of servers are disclosed. An example system includes a processor, an alarm linkage database to store information representative of alarm configurations for a plurality of servers, and a memory comprising machine readable instructions. When executed, the instructions cause the processor to perform operations comprising accessing alarm configurations in the alarm linkage database for a subset of the plurality of servers in response to a first request, initiating a change in respective alarm configurations of the subset of the plurality of the servers, and initiating propagation of the alarm configuration to the subset of the servers, the subset including more than one server.

摘要翻译： 公开了用于管理服务器的报警配置的系统，方法和制造。 示例系统包括处理器，用于存储表示多个服务器的警报配置的信息的警报联动数据库，以及包含机器可读指令的存储器。 当执行时，指令使得处理器执行操作，包括响应于第一请求，为多个服务器的子集访问警报联动数据库中的警报配置，启动多个服务器的子集的相应警报配置的改变 服务器，并启动报警配置传播到服务器的子集，该子集包括多个服务器。

公开(公告)号：US20110233140A1

公开(公告)日：2011-09-29

申请号：US13071351

申请日：2011-03-24

申请人： John Berger

发明人： John Berger

IPC分类号： C02F1/00

CPC分类号： B01D24/04 ,  E02B3/023 ,  E02B5/085 ,  E02B8/02 ,  E02B8/023 ,  Y02A10/28

摘要： A device for removing silt from flowing water by temporarily slowing the water enough to permit silt to settle naturally to the bottom is disclosed. The water may be slowed by a combination of increased depth and obstructions in the form of rough rocks and chain link fencing.

摘要翻译： 公开了一种用于通过暂时减缓足以使淤泥自然沉降到底部的水来从流水中除去淤泥的装置。 通过粗糙岩石和链条围栏形式的增加的深度和障碍物的组合，水可能会减慢。

公开(公告)号：US4759529A

公开(公告)日：1988-07-26

申请号：US51714

申请日：1987-05-20

申请人： John Berger ,  Jack Rollins

发明人： John Berger ,  Jack Rollins

IPC分类号： F16K3/02 ,  F16K3/20

CPC分类号： F16K3/0236

摘要： The improved pre-loaded valve follower sealing apparatus comprises a follower ring and flange insert assembly. The assembly includes a pair of hollow cylinders compressively containing a follower preload and sealing element. That follower preload and sealing element is substantially annular in shape, but has an interior fluid contacting surface which is concave in transverse cross-section when not under compression, but which is rendered substantially smoothly cylindrical when placed under compression.

摘要翻译： 改进的预加载阀随动件密封装置包括从动环和凸缘插入组件。 组件包括一对压缩地容纳随动件预紧和密封元件的空心圆筒。 该跟随器预加载和密封元件的形状基本上是环形的，但是具有内部流体接触表面，该表面在不在压缩下时在横截面上是凹形的，但是当被置于压缩状态下时呈现为基本平滑的圆柱形。

公开(公告)号：US20110165535A1

公开(公告)日：2011-07-07

申请号：US12985959

申请日：2011-01-06

申请人： John Berger ,  Dmitri Boutoussov

发明人： John Berger ,  Dmitri Boutoussov

IPC分类号： A61C3/00

CPC分类号： A61B18/22 ,  A61B18/203 ,  A61B2018/202 ,  A61C1/0007 ,  A61C1/0046

摘要： A handpiece for a medical instrumentation device is formed with manually deformable ribs on an outer sleeve. The ribs align with conductive surfaces inside the handpiece that make contact with an internal flexible electronic circuit to activate the device when force is applied to the ribs. Removing the force deactivates the device.

摘要翻译： 用于医疗仪器装置的手持件在外套筒上形成有可手动变形的肋。 这些肋与机身内部的导电表面对准，该导电表面与内部的柔性电子电路接触，以在对肋施加力时激活该装置。 拆卸该力将使设备无效。

公开(公告)号：US07850618B2

公开(公告)日：2010-12-14

申请号：US12008349

申请日：2008-01-10

申请人： Malcolm Howard Wilkinson ,  Clive Andrew Ramsden ,  Philip John Berger

发明人： Malcolm Howard Wilkinson ,  Clive Andrew Ramsden ,  Philip John Berger

IPC分类号： A61B5/08

CPC分类号： A61B5/4818 ,  A61B5/08 ,  A61B8/08

摘要： The present invention relates to a method of determining characteristics of biological tissues in humans and animals. In particular, it relates to determining the characteristics of tissues such as the lungs and airways by introducing a sound to the tissue, and recording the sound. The invention further includes an apparatus capable of such measurement. In a first aspect of the present invention there is provided a method of determining characteristics of biological tissue in situ, including: introducing a sound to the tissue at first position; detecting the sound at another position spaced from the first position after it has traveled through the tissue; calculating the velocity and attenuation of sound that has traveled through the tissue from the first position to another position; and correlating the velocity and attenuation of the detected sound to characteristics of the biological tissue.

摘要翻译： 本发明涉及一种确定人和动物生物组织特征的方法。 特别涉及通过向组织引入声音并记录声音来确定诸如肺和气道的组织的特征。 本发明还包括能够进行这种测量的装置。 在本发明的第一方面，提供了一种确定生物组织的特征的方法，包括：在第一位置向所述组织引入声音; 在其已经穿过组织后检测与第一位置间隔开的另一位置处的声音; 计算已经穿过组织从第一位置到另一位置的声音的速度和衰减; 并将检测到的声音的速度和衰减与生物组织的特征相关联。

公开(公告)号：US07708697B2

公开(公告)日：2010-05-04

申请号：US11107999

申请日：2005-04-15

申请人： Malcolm Howard Wilkinson ,  Clive Andrew Ramsden ,  Philip John Berger ,  Peter Camilleri ,  Jacqueline Anne Wilson ,  Frank Samuhel

发明人： Malcolm Howard Wilkinson ,  Clive Andrew Ramsden ,  Philip John Berger ,  Peter Camilleri ,  Jacqueline Anne Wilson ,  Frank Samuhel

IPC分类号： A61B5/08

CPC分类号： A61B5/085 ,  A61B5/08 ,  A61B5/4818 ,  A61B5/7257 ,  A61B8/08 ,  A61M16/0006 ,  A61M16/0051 ,  A61M16/026 ,  A61M16/0666 ,  A61M2016/0039 ,  A61M2230/04 ,  A61M2230/205 ,  A61M2230/65

摘要： Airway monitoring apparatus 30 includes a driver 6 for applying sound in the audible frequency range to the airway of a subject and a detector 7 for monitoring the response of the airway, e.g. by detecting transmitted sound signal components and/or reflected sound signal components. Variations in the detected sound signal, e.g. energy, due to attenuation of the signal, give an indication of the state of the airway, e.g. airway patency, and can be used to monitor sleep-disordered breathing events, such as apnea and hypopnea, and to provide a breathing event index, e.g. AHI. The apparatus may provide servo-control for a respiratory assist device, such as a positive airway pressure device, so as to provide an appropriate pressure level setting. It may allow for home use of such devices and for home titration. It may also assist in discriminating central and obstructive breathing events, and in providing a measure of airway resistance.

摘要翻译： 气道监测装置30包括用于将可听频率范围内的声音施加到被检体的气道的驱动器6和用于监测气道的反应的检测器7，例如， 通过检测发送的声音信号分量和/或反射的声音信号分量。 检测到的声音信号的变化，例如， 能量，由于信号的衰减，给出气道状态的指示，例如。 气道通畅，并且可以用于监测睡眠呼吸障碍的呼吸事件，例如呼吸暂停和呼吸不足，并提供呼吸事件指数，例如呼吸道呼吸。 AHI。 该装置可以为诸如正气道压力装置的呼吸辅助装置提供伺服控制，以便提供适当的压力水平设置。 它可以允许家用这种装置和家庭滴定。 它也可以帮助区分中枢和阻塞性呼吸事件，并提供气道阻力的量度。