公开(公告)号：US20220299144A1

公开(公告)日：2022-09-22

申请号：US17697076

申请日：2022-03-17

申请人： Alexandra BONNYMAN ,  Kerry R. LOVE ,  Larry WEINER ,  John Christopher LOVE ,  Espir KAHATT ,  Ziad AL-SHAMSIE ,  Ben REISMAN ,  Alex GOLDBLATT

发明人： Alexandra BONNYMAN ,  Kerry R. LOVE ,  Larry WEINER ,  John Christopher LOVE ,  Espir KAHATT ,  Ziad AL-SHAMSIE ,  Ben REISMAN ,  Alex GOLDBLATT

IPC分类号： F16L37/38 ,  F16L37/098

摘要： An aseptic connector includes first and second matable housings each comprising a plurality of connectors for fluid conduits. The fluid conduits enter the housings and may be force-fitted onto barbs or flanges on one side of the connectors, or may instead be molded directly onto the connectors. When the housings are joined, the opposite sides of the connectors mate to form fluid seals, thereby establishing fluid pathways between now-connected sets of tubes.

公开(公告)号：US20150253237A1

公开(公告)日：2015-09-10

申请号：US14523376

申请日：2014-10-24

申请人： Marc Castellarnau ,  Gregory Lee Szeto ,  Darrell J. Irvine ,  John Christopher Love ,  Joel Voldman

发明人： Marc Castellarnau ,  Gregory Lee Szeto ,  Darrell J. Irvine ,  John Christopher Love ,  Joel Voldman

IPC分类号： G01N15/14

CPC分类号： G01N15/1463 ,  G01N15/10 ,  G01N15/1484 ,  G01N35/00732 ,  G01N2015/0065 ,  G01N2015/008 ,  G01N2015/1006 ,  G01N2015/149 ,  G01N2035/00811 ,  G01N2035/00831

摘要： A method of tracking cell identity across analytical platforms uses stochastic barcoding (SB). SB uses a randomly generated code based on one or more of the number, color and position of beads encapsulated together with a set of cells of interest. SB use is demonstrated in an application where cells are transferred from a microwell array into a microtitre plate while keeping their identity, and obtained an average identification accuracy of 96% for transfer of 100 blocks. Model scaling of the method up to 1000 blocks demonstrated that SB is able to achieve approximately 90% accuracy.

摘要翻译： 通过分析平台跟踪细胞身份的方法使用随机条形码（SB）。 SB使用随机生成的代码，其基于与感兴趣的一组单元格一起封装的珠的数量，颜色和位置中的一个或多个。 SB的使用在其中将细胞从微孔阵列转移到微量滴定板同时保持其同一性的应用中得到证明，并且获得了100个块的转移的平均识别精度为96％。 该方法的模型缩放高达1000块，证明SB能够实现大约90％的精度。

公开(公告)号：US08569046B2

公开(公告)日：2013-10-29

申请号：US12390279

申请日：2009-02-20

申请人： John Christopher Love ,  Eliseo Papa ,  Craig M. Story

发明人： John Christopher Love ,  Eliseo Papa ,  Craig M. Story

IPC分类号： C12M1/34 ,  C12M3/00 ,  C40B30/06 ,  C40B40/02

CPC分类号： C12M23/16 ,  B01L3/5085 ,  B01L9/50 ,  B01L2300/0854 ,  C12M23/12

摘要： A microarray formed in a planar surface of a moldable slab, the microarray including a plurality of microwell sets comprising a plurality of microwells formed in the planar surface of the moldable slab, each microwell being sized to contain at least a single cell, and a plurality of microchannels formed in the planar surface of the moldable slab, the plurality of microchannels being configured to permit liquid from a first region of the microarray to transit to a second region of the microarray.

摘要翻译： 一种微阵列，其形成在可模制板坯的平坦表面中，所述微阵列包括多个微孔组，所述微孔组包括形成在所述可模制板坯的平坦表面中的多个微孔，每个微孔的尺寸设置成容纳至少一个单电池， 的微通道，其形成在可模制板坯的平坦表面中，所述多个微通道被配置为允许来自微阵列的第一区域的液体转移到微阵列的第二区域。

公开(公告)号：US6096761A

公开(公告)日：2000-08-01

申请号：US117980

申请日：1998-08-11

申请人： Jean-Paul Rene Marie Bosmans ,  John Christopher Love ,  Michel Anna Jozef Decleyn ,  Henri Elisabeth Frans D'Haen

发明人： Jean-Paul Rene Marie Bosmans ,  John Christopher Love ,  Michel Anna Jozef Decleyn ,  Henri Elisabeth Frans D'Haen

IPC分类号： A01N43/40 ,  A01N43/58 ,  C07D211/68 ,  C07D237/30 ,  C07D401/00

CPC分类号： A01N43/40 ,  A01N43/58 ,  C07D211/68 ,  C07D237/30 ,  C07D401/00

摘要： The present invention of compounds of formula (I), ##STR1## a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R.sup.1 is C.sub.1-6 alkyloxy, C.sub.2-6 alkenyloxy or C.sub.2-6 alkynyloxy; R.sup.2 is hydrogen or C.sub.1-6 alkyloxy, or when taken together R.sup.1 and R.sup.2 may form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C.sub.1-6 alkyl; R.sup.3 is hydrogen or halo; R.sup.4 is hydrogen or C.sub.1-6 alkyl; L is C.sub.3-6 cycloalkyl, C.sub.5-6 cycloalkanone, C.sub.2-6 alkenyl optionally substituted with aryl, or L is a radical of formula -Alk-R.sup.5 -, Alk-X--R.sup.6, -Alk-Y--C(.dbd.O)--R.sup.8, or -Alk-Y--C(.dbd.O)--NR.sup.10 R.sup.11 wherein each Alk is C.sub.1-12 alkanediyl; and R.sup.5 is hydrogen, cyano, C.sub.1-6 alkylsulfonylamino, C.sub.3-6 cycloalkyl, C.sub.5-6 cycloalkanone, aryl, di(aryl)methyl or a heterocyclic ringsystem; R.sup.6 is hydrogen, C.sub.1-6 alkyl, hydroxyC.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, aryl or heterocyclic ringsystem; X is O, S, SO.sub.2 or NR.sup.7 ; said R.sub.7 being hydrogen, C.sub.1-6 alkyl or aryl; R.sup.8 is hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, aryl, arylC.sub.1-6 alkyl, di(aryl)methyl, C.sub.1-6 alkyloxy or hydroxy; Y is NR.sup.9 or a direct bond; said R.sup.9 being hydrogen, C.sub.1-6 alkyl or aryl R.sup.10 and R.sup.11 each independently are hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, aryl or arylC.sub.1-6 alkyl, or R.sup.10 and R.sup.11 combined with the nitrogen atom bearing R.sup.10 and R.sup.11 may form a pyrrolidinyl or piperidinyl ring both being optionally substituted with C.sub.1-6 alkyl, amino or mono or di(C.sub.1-6 alkyl)amino, or said R.sup.10 and R.sup.11 combined with the nitrogen bearing R.sup.10 and R.sup.11 may form a piperazinyl or 4-morpholinyl radical both being optionally substituted with C.sub.1-6 alkyl. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impairment of gastric emptying.

公开(公告)号：US20100216228A1

公开(公告)日：2010-08-26

申请号：US12390279

申请日：2009-02-20

申请人： John Christopher Love ,  Eliseo Papa ,  Craig M. Story

发明人： John Christopher Love ,  Eliseo Papa ,  Craig M. Story

IPC分类号： C12M1/34

CPC分类号： C12M23/16 ,  B01L3/5085 ,  B01L9/50 ,  B01L2300/0854 ,  C12M23/12

摘要： A microarray formed in a planar surface of a moldable slab, the microarray including a plurality of microwell sets comprising a plurality of microwells formed in the planar surface of the moldable slab, each microwell being sized to contain at least a single cell, and a plurality of microchannels formed in the planar surface of the moldable slab, the plurality of microchannels being configured to permit liquid from a first region of the microarray to transit to a second region of the microarray.

摘要翻译： 一种微阵列，其形成在可模制板坯的平坦表面中，所述微阵列包括多个微孔组，所述微孔组包括形成在所述可模制板坯的平坦表面中的多个微孔，每个微孔的尺寸设置成容纳至少一个单电池， 的微通道，其形成在可模制板坯的平坦表面中，所述多个微通道被配置为允许来自微阵列的第一区域的液体转移到微阵列的第二区域。

公开(公告)号：US06348700B1

公开(公告)日：2002-02-19

申请号：US09178747

申请日：1998-10-27

申请人： James C. Ellenbogen ,  John Christopher Love

发明人： James C. Ellenbogen ,  John Christopher Love

IPC分类号： H01C3524

CPC分类号： H01L51/0595 ,  B82Y10/00 ,  H01L51/0035 ,  Y10S977/762 ,  Y10S977/94

摘要： A monomolecular rectifying wire is provided that includes a molecular conducting wire that has been modified to embed a rectifying diode integrally therein. The modified conducting wire includes an electron donating section, an electron accepting section, and an insulating group separating the electron donating and accepting sections. Monomolecular logical gates and more complex logic structures that operate by the conduction of electrical currents are constructed by combinations of molecular rectifying wires, molecular conducting wires, and molecular resistive wires to form a single molecule that electrically exhibits a desired Boolean logic function.

摘要翻译： 提供了一种单分子整流线，其包括已经被改进以将整流二极管整体地嵌入其中的分子导线。 修饰的导线包括给电子部分，电子接收部分和分离供电和接收部分的绝缘组。 单分子逻辑门和通过电流传导操作的更复杂的逻辑结构通过分子整流线，分子导线和分子电阻线的组合构成，以形成电展现所需布尔逻辑函数的单分子。