公开(公告)号：US20130131490A1

公开(公告)日：2013-05-23

申请号：US13453070

申请日：2012-04-23

申请人： John Huston, III ,  Clifford R. Jack, JR. ,  Kevin J. Glaser ,  Armando Manduca ,  Joel P. Felmlee ,  Richard L. Ehman ,  Matthew C. Murphy

发明人： John Huston, III ,  Clifford R. Jack, JR. ,  Kevin J. Glaser ,  Armando Manduca ,  Joel P. Felmlee ,  Richard L. Ehman ,  Matthew C. Murphy

IPC分类号： A61B5/055

CPC分类号： A61B5/055 ,  A61B5/0042 ,  A61B5/0051 ,  A61B5/4088 ,  G01R33/56358

摘要： A system and method for analyzing a subject using a magnetic resonance imaging (MRI) system is provided. The technique includes positioning a subject within the MRI system and coupling a driver to the subject to impart vibrational energy to the subject. The technique further includes using the MRI system and in coordination with operation of the driver, acquiring medical imaging data from the subject's brain and deriving stiffness information of the subject's brain from the medical imaging data. A report, such as an image, can be provided indicating the stiffness information of the subject's brain relative to baseline stiffness information to indicate a status of the subject with respect to a neurodegenerative disease.

摘要翻译： 提供了一种使用磁共振成像（MRI）系统分析对象的系统和方法。 该技术包括将对象定位在MRI系统内并且将驾驶员与受试者联接以向对象施加振动能量。 该技术还包括使用MRI系统并与驾驶员的操作协调，从受试者的大脑获取医学成像数据，并从医学成像数据导出受检者脑部的刚度信息。 可以提供诸如图像的报告，指示受试者的脑相对于基线刚度信息的刚度信息，以指示受试者相对于神经变性疾病的状态。

公开(公告)号：US06259940B1

公开(公告)日：2001-07-10

申请号：US09301246

申请日：1999-04-28

申请人： Matthew A. Bernstein ,  John Huston, III

发明人： Matthew A. Bernstein ,  John Huston, III

IPC分类号： A61B5055

CPC分类号： G01R33/5635 ,  G01R33/56308 ,  G01R33/56518 ,  G01R33/56581

摘要： In an MRI system using high-performance gradient hardware, a method includes de-rating selected lobes in a 2DTOF imaging pulse sequence; employing images from the two-dimensional imagery to detect the presence of disease; and performing three-dimensional contrast-enhanced MRA if disease was detected at a sufficiently high level to make three-dimensional imaging useful. By de-rating selected lobes of the 2DTOF imaging pulse sequence, sensitivity to carotid stenosis at or above the clinically important range of 60-70% is achieved.

摘要翻译： 在使用高性能梯度硬件的MRI系统中，一种方法包括以2DTOF成像脉冲序列降低所选择的瓣; 使用二维图像的图像来检测疾病的存在; 并且如果在足够高的水平检测到疾病以使三维成像有用，则执行三维造影增强MRA。 通过降低2DTOF成像脉冲序列的选定的瓣膜，实现了临床上重要范围为60-70％之间的颈动脉狭窄的敏感性。