公开(公告)号：US11698428B2

公开(公告)日：2023-07-11

申请号：US17585742

申请日：2022-01-27

申请人： The University of Tokyo ,  CANON MEDICAL SYSTEMS CORPORATION

发明人： Takaaki Nara ,  Motofumi Fushimi ,  Naohiro Eda ,  Seiichi Shin ,  Hitoshi Yamagata ,  Koji Yano ,  Hiroyuki Fujita

IPC分类号： G01R33/44 ,  G01R33/563 ,  G01R33/56 ,  A61B5/00 ,  A61B5/055 ,  G01R33/48

CPC分类号： G01R33/443 ,  A61B5/0042 ,  A61B5/055 ,  G01R33/4806 ,  G01R33/5608 ,  G01R33/56358 ,  A61B2576/026

摘要： An information processing apparatus according to an embodiment includes a processing circuit. The processing circuit acquires a measurement field corresponding to a spatial distribution of a predetermined physical quantity in a subject of measurement. The processing circuit calculates an unknown quantity in the subject of measurement based on a first equation between the measurement field and the unknown quantity having spatial dependence, and on the acquired measurement field. The first equation is one that is acquired based on a second equation expressing a dual field divergence of which can be expressed using the measurement field, by using the measurement field and the unknown quantity, and on the Helmholtz decomposition of the dual field.

公开(公告)号：US09958521B2

公开(公告)日：2018-05-01

申请号：US15089571

申请日：2016-04-03

申请人： Tesla Health, Inc

发明人： Jeffrey Howard Kaditz ,  Andrew Gettings Stevens

IPC分类号： G06K9/00 ,  G01R33/48 ,  G01N24/08 ,  G01R33/44 ,  G01R33/465 ,  G01R33/563

CPC分类号： G01R33/48 ,  G01N24/08 ,  G01R33/448 ,  G01R33/465 ,  G01R33/4804 ,  G01R33/56358

摘要： A system that determines an invariant magnetic-resonance (MR) signature of a biological sample is disclosed. During operation, the system determines a magnetic-resonance (MR) model of voxels in a biological sample based on differences between MR signals associated with the voxels in multiple scans and simulated MR signals. The MR signals are measured or captured by an MR scanner in the system during multiple MR scans, and based on scanning instructions, and the simulated MR signals for the biological sample are generated using the MR model and the scanning instructions. Moreover, the system iteratively modifies the scanning instructions (including a magnetic-field strength and/or a pulse sequence) in the MR scans based on the differences until a convergence criterion is achieved. Then, the system stores, in memory, an identifier of the biological sample and a magnetic-field-strength-invariant MR signature of the biological sample that is associated with the MR model.

公开(公告)号：US20170332937A1

公开(公告)日：2017-11-23

申请号：US15524948

申请日：2015-11-13

申请人： OHIO STATE INNOVATION FOUNDATION

发明人： Arunark KOLIPAKA ,  John W. ARNOLD ,  F. Paul LEE ,  Richard D. WHITE

IPC分类号： A61B5/055 ,  G01R33/563 ,  A61B5/00

CPC分类号： A61B5/055 ,  A61B5/0051 ,  G01R33/56358

摘要： Systems and methods are described for inducing tissue vibration for magnetic resonance elastography is described. The system includes a hydraulic drive component that is mechanically linked to a pneumatic drive component. The pneumatic drive component is pneumatically linked to a passive pneumatic actuator component that is positionable on a patient proximate to a target tissue. Alternating linear movement of an actuator piston within the passive actuator component induces vibration of the target tissue. The frequency of the alternating linear movement of the actuator piston within the passive pneumatic actuator component is controlled by adjusting how fluid is pumped in the hydraulic drive component.

公开(公告)号：US20170265772A1

公开(公告)日：2017-09-21

申请号：US15611991

申请日：2017-06-02

申请人： TOSHIBA MEDICAL SYSTEMS CORPORATION

发明人： Sadanori TOMIHA

IPC分类号： A61B5/055 ,  A61B17/34 ,  A61B5/00 ,  G01R33/3415 ,  G01R33/563 ,  A61B90/00 ,  G01R33/28

CPC分类号： A61B5/055 ,  A61B5/0051 ,  A61B17/3403 ,  A61B2017/3411 ,  A61B2090/3958 ,  G01R33/285 ,  G01R33/3415 ,  G01R33/56358

摘要： A coil pad according to one embodiment is a coil pad that is placed between a receiving coil and a subject. The receiving coil is mounted on the subject and receives a magnetic resonance signal emitted from the subject. The coil pad includes a pad opening and a vibrating portion. The pad opening is aligned with a coil opening included in the receiving coil and forms a through-hole between the coil opening and the subject. The vibrating portion vibrates with a medium that transmits vibration being filled therein.

公开(公告)号：US20170192077A1

公开(公告)日：2017-07-06

申请号：US15399479

申请日：2017-01-05

申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

发明人： Bogdan Dzyubak ,  Jun Chen ,  Richard Ehman

IPC分类号： G01R33/58 ,  A61B5/055

CPC分类号： G01R33/58 ,  A61B5/0051 ,  A61B5/055 ,  G01R33/56358

摘要： A phantom for magnetic resonance elastography (MRE) is provided. In particular, systems and methods for a phantom that is capable of generating a wave-like pattern in MRE images where a wavelength of the generated wave-like pattern is controlled by the phantom geometry. The geometrically controlled wavelength enables the phantom to calibrate MRE image acquisition and mechanical property calculation.

公开(公告)号：US09562960B2

公开(公告)日：2017-02-07

申请号：US12935968

申请日：2009-04-03

申请人： Arunark Kolipaka ,  Armando Manduca ,  Kiaran P. Mcgee ,  Richard L. Ehman ,  Kevin J. Glaser

发明人： Arunark Kolipaka ,  Armando Manduca ,  Kiaran P. Mcgee ,  Richard L. Ehman ,  Kevin J. Glaser

IPC分类号： A61B5/055 ,  G01R33/563 ,  A61B5/00

CPC分类号： G01R33/56358 ,  A61B5/0051 ,  A61B5/416

摘要： A method for magnetic resonance elastography (“MRE”) is described, in which an MRE inversion that accounts for waves propagating in a finite, bounded media is employed. A vibratory motion is induced in a subject and MRE is performed to measure one or more components of the resulting displacement produced in the subject. This displacement data is subsequently filtered to provide a more accurate and computationally efficient method of inversion. Wave equations based on the geometry of the bounded media are then utilized to calculate the material properties of the subject. Such a method allows for the performance of MRE on tissues such as the heart, eye, bladder, and prostate with more accurate results.

摘要翻译： 描述了一种用于磁共振弹性成像（“MRE”）的方法，其中采用考虑在有限的有界介质中传播的波的MRE反演。 在受试者中诱发振动，并执行MRE以测量在受试者中产生的所得到的位移的一个或多个成分。 随后对该位移数据进行滤波以提供更精确和计算上有效的反演方法。 然后利用基于有界介质的几何形状的波动方程来计算受试者的材料性质。 这种方法允许在更精确的结果上在诸如心脏，眼睛，膀胱和前列腺的组织上表现MRE。

公开(公告)号：US20160334490A1

公开(公告)日：2016-11-17

申请号：US15154128

申请日：2016-05-13

申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

发明人： Joshua D. Trzasko ,  Richard L. Ehman ,  Philip A. Araoz

IPC分类号： G01R33/563 ,  G01R33/561 ,  G01R33/48

CPC分类号： G01R33/56358 ,  G01R33/243 ,  G01R33/4828

摘要： Systems and methods for simultaneous water-fat magnetic resonance imaging (“MRI”) and magnetic resonance elastography (“MRE”) using an integrated data acquisition and reconstruction scheme are described. This integrated acquisition and reconstruction technique can mitigate motion misregistration and provide improved image SNR relative to existing multiparametric acquisition techniques that require multiple separate acquisitions.

摘要翻译： 描述了使用集成数据采集和重建方案同时进行水脂磁共振成像（“MRI”）和磁共振弹性成像（“MRE”）的系统和方法。 这种集成采集和重建技术可以减轻运动重合失调，并提供相对于需要多次分离采集的现有多参数采集技术的改进图像信噪比。

公开(公告)号：US09480414B2

公开(公告)日：2016-11-01

申请号：US13927401

申请日：2013-06-26

申请人： Stefan Popescu

发明人： Stefan Popescu

IPC分类号： A61B5/055 ,  G01R33/563 ,  A61B8/08 ,  A61B5/02

CPC分类号： A61B5/055 ,  A61B5/02007 ,  A61B8/485 ,  G01R33/56358

摘要： In a methods for elastography in a defined region of an examined person, a radio-frequency pulse is radiated to manipulate a transverse magnetization in the defined region and at least one additional radio-frequency pulse with a spatial selectivity of the amplitude is radiated to generate shear waves in the defined region. A magnetic resonance signal from the defined region is detected and a determination of a value describing the tissue elasticity in the defined region is made based on the magnetic resonance signal.

摘要翻译： 在被检查人员的限定区域中的弹性成像方法中，辐射射频脉冲以操纵限定区域中的横向磁化，并且辐射具有幅度空间选择性的至少一个附加射频脉冲以产生 定义区域内的剪切波。 检测来自限定区域的磁共振信号，并且基于磁共振信号确定描述限定区域中的组织弹性的值。

公开(公告)号：US20150241540A1

公开(公告)日：2015-08-27

申请号：US14426842

申请日：2013-09-09

申请人： KONINKLIJKE PHILIPS N.V.

发明人： Peter Vernickel ,  Daniel Wirtz ,  Christoph Leussler ,  Peter Mazurkewitz

IPC分类号： G01R33/563 ,  G01R33/385 ,  G01R33/56 ,  G01R33/3815 ,  G01R33/30 ,  G01R33/567

CPC分类号： G01R33/56375 ,  G01R33/307 ,  G01R33/3815 ,  G01R33/385 ,  G01R33/5608 ,  G01R33/56358 ,  G01R33/56509 ,  G01R33/56563 ,  G01R33/567 ,  G01R33/5676

摘要： The invention provides for a medical instrument (200, 400, 500) comprising a magnetic resonance imaging system (202), a transducer (222) for mechanically vibrating at least a portion of the subject within the imaging zone. Instructions cause a processor (236) controlling the medical instrument to: control (100) the transducer to vibrate; control (102) the magnetic resonance imaging system to repeatedly acquire the magnetic resonance data (252) using a first spatially encoding pulse sequence (250); control (104) the magnetic resonance imaging system to acquire navigator data (256) using a second spatially encoding pulse sequence (254); construct (106) a set of navigator profiles (258, 804, 904, 1004, 1108, 1208, 1308) using the navigator data; determine (108) at least one parameter (260) descriptive of transducer vibrations using the set of navigator profiles; and reconstruct (110) at least one magnetic resonance rheology image (262) from the magnetic resonance data.

摘要翻译： 本发明提供一种包括磁共振成像系统（202）的医疗器械（200,400,500），用于在成像区内机械地振动受试者的至少一部分的换能器（222）。 指令使处理器（236）控制医疗器械：控制（100）换能器振动; 控制（102）所述磁共振成像系统以使用第一空间编码脉冲序列（250）重复获取所述磁共振数据（252）。 控制（104）所述磁共振成像系统以使用第二空间编码脉冲序列（254）获取导航器数据（256）; 使用导航器数据构造（106）一组导航器简档（258,804,904,1004,1108,1208,1308）; 使用所述一组导航器轮廓来确定（108）描述换能器振动的至少一个参数（260）; 并从磁共振数据重建（110）至少一个磁共振流变学图像（262）。

公开(公告)号：US20140276230A1

公开(公告)日：2014-09-18

申请号：US13831160

申请日：2013-03-14

申请人： THE TRUSTEES OF DARTMOUTH COLLEGE

发明人： Adam J. Pattison ,  Matthew DJ McGarry ,  Keith D. Paulsen ,  John B. Weaver

IPC分类号： G06F19/00 ,  G01R33/563 ,  A61B5/11 ,  G01N3/32

CPC分类号： G06F19/3437 ,  A61B5/0051 ,  A61B5/055 ,  A61B5/1128 ,  A61B5/4064 ,  A61B5/6868 ,  G01N3/32 ,  G01N2203/0005 ,  G01N2203/0069 ,  G01N2203/0073 ,  G01N2203/0094 ,  G01N2203/0218 ,  G01R33/56358 ,  G06F19/00 ,  G06F19/3481 ,  G16H50/50

摘要： A system for determining parameters of porous media or material, which in an embodiment is biological tissue, includes an actuator and a displacement monitor. The actuator is adapted to apply a displacement to tissue at a particular frequency selected from a range of frequencies, and the force monitor adapted to monitor a mechanical response of tissue. The system also has a processor coupled to drive the actuator and to read the mechanical response, the processor coupled to execute from memory a poroelastic model of mechanical properties of the material, and a convergence procedure for determining parameters for the poroelastic model such that the model predicts mechanical response of the tissue to within limits.

摘要翻译： 用于确定在一个实施方案中为生物组织的多孔介质或材料的参数的系统包括致动器和位移监测器。 致动器适于以选自频率范围的特定频率向组织施加位移，并且力监测器适于监测组织的机械响应。 该系统还具有耦合以驱动致动器并且读取机械响应的处理器，该处理器被耦合以从存储器执行材料的机械性能的多弹性模型，以及用于确定多孔弹性模型的参数的收敛过程，使得该模型 将组织的机械反应预测在限度内。