公开(公告)号：US07902348B2

公开(公告)日：2011-03-08

申请号：US12354668

申请日：2009-01-15

申请人： John J. O'Shea ,  Warren J. Leonard ,  James A. Johnston ,  Sarah M. Russell ,  Daniel W. McVicar ,  Masaru Kawamura

发明人： John J. O'Shea ,  Warren J. Leonard ,  James A. Johnston ,  Sarah M. Russell ,  Daniel W. McVicar ,  Masaru Kawamura

IPC分类号： C12N15/52 ,  C12N15/12

CPC分类号： C12N9/1205 ,  A61K48/00 ,  C07K16/40

摘要： An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.

摘要翻译： 分离的多核苷酸编码JAK-3蛋白。 JAK-3蛋白是具有约125kDa分子量的蛋白酪氨酸激酶，其具有串联的不相同的催化结构域，缺少SH2或SH3结构域，并且在NK细胞和刺激或转化的T细胞中表达，但不在休息T 细胞。 蛋白质本身和对该蛋白质的抗体也被提出。 此外，鉴定用于调节免疫系统的治疗剂的方法利用上述。

公开(公告)号：US5583002A

公开(公告)日：1996-12-10

申请号：US987966

申请日：1992-12-11

申请人： Augusto C. Ochoa ,  Hiromoto Mizuguchi ,  John J. O'Shea ,  Dan L. Longo ,  Cynthia M. Loeffler

发明人： Augusto C. Ochoa ,  Hiromoto Mizuguchi ,  John J. O'Shea ,  Dan L. Longo ,  Cynthia M. Loeffler

IPC分类号： A61K38/00 ,  A61K38/20 ,  A61K39/00 ,  C07K14/47 ,  C07K16/18 ,  G01N33/574

CPC分类号： C07K16/18 ,  A61K38/2013 ,  C07K14/4703 ,  A61K39/00

摘要： A soluble immunosuppressive factor present in serum derived from tumor-bearing mammals, is associated with changes in TCR protein subunit levels and T-lymphocyte signal transduction pathway proteins. These changes provide a method of determining the level of immunosuppression in a mammal by determining the level of expression of at least one selected TCR subunit protein, or a protein in the T lymphocyte signal transduction pathway, and comparing the level to that found in non-immunosuppressed individuals. The method is useful to identify patients having T lymphocytes capable of activation for immunotherapy and for identifying agents which cause or reverse immunosuppression. An isolated immunosuppressive factor associated with the level of expression of the proteins is useful for suppressing the immune response, for example, in organ transplantation.

摘要翻译： 存在于源自荷瘤哺乳动物的血清中的可溶性免疫抑制因子与TCR蛋白亚基水平和T淋巴细胞信号转导途径蛋白质的变化相关。 这些变化提供了通过确定至少一种选择的TCR亚单位蛋白或T淋巴细胞信号转导途径中的蛋白质的表达水平，并将其水平与非淋巴细胞中发现的水平进行比较来确定哺乳动物免疫抑制水平的方法， 免疫抑制个体。 该方法可用于鉴定具有能够激活免疫治疗的T淋巴细胞的患者和用于鉴定引起或逆转免疫抑制的药物。 与蛋白质表达水平相关的分离的免疫抑制因子可用于抑制免疫应答，例如在器官移植中。

公开(公告)号：US20110177526A1

公开(公告)日：2011-07-21

申请号：US13041204

申请日：2011-03-04

申请人： John J. O'Shea ,  Warren J. Leonard ,  James A. Johnston ,  Sarah M. Russell ,  Daniel W. McVicar ,  Masaru Kawamura

发明人： John J. O'Shea ,  Warren J. Leonard ,  James A. Johnston ,  Sarah M. Russell ,  Daniel W. McVicar ,  Masaru Kawamura

IPC分类号： G01N33/68 ,  C12Q1/48

CPC分类号： C12N9/1205 ,  A61K48/00 ,  C07K16/40

摘要： An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.

摘要翻译： 分离的多核苷酸编码JAK-3蛋白。 JAK-3蛋白是具有约125kDa分子量的蛋白酪氨酸激酶，其具有串联的不相同的催化结构域，缺少SH2或SH3结构域，并且在NK细胞和刺激或转化的T细胞中表达，但不在休息T 细胞。 蛋白质本身和对该蛋白质的抗体也被提出。 此外，鉴定用于调节免疫系统的治疗剂的方法利用上述。

公开(公告)号：US20090137787A1

公开(公告)日：2009-05-28

申请号：US12354668

申请日：2009-01-15

申请人： John J. O'Shea ,  Warren J. Leonard ,  James A. Johnston ,  Sarah M. Russell ,  Daniel W. McVicar ,  Masaru Kawamura

发明人： John J. O'Shea ,  Warren J. Leonard ,  James A. Johnston ,  Sarah M. Russell ,  Daniel W. McVicar ,  Masaru Kawamura

IPC分类号： C07H21/04

CPC分类号： C12N9/1205 ,  A61K48/00 ,  C07K16/40

摘要： An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.

摘要翻译： 分离的多核苷酸编码JAK-3蛋白。 JAK-3蛋白是具有约125kDa分子量的蛋白酪氨酸激酶，其具有串联的不相同的催化结构域，缺少SH2或SH3结构域，并且在NK细胞和刺激或转化的T细胞中表达，但不在休息T 细胞。 蛋白质本身和对该蛋白质的抗体也被提出。 此外，鉴定用于调节免疫系统的治疗剂的方法利用上述。

公开(公告)号：US07488808B2

公开(公告)日：2009-02-10

申请号：US11195197

申请日：2005-08-01

申请人： John J. O'Shea ,  Warren J. Leonard ,  James A. Johnston ,  Sarah M. Russell ,  Daniel W. McVicar ,  Masaru Kawamura

发明人： John J. O'Shea ,  Warren J. Leonard ,  James A. Johnston ,  Sarah M. Russell ,  Daniel W. McVicar ,  Masaru Kawamura

IPC分类号： C07K16/40 ,  C07K16/18

CPC分类号： C12N9/1205 ,  A61K48/00 ,  C07K16/40

摘要： An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.

摘要翻译： 分离的多核苷酸编码JAK-3蛋白。 JAK-3蛋白是具有约125kDa分子量的蛋白酪氨酸激酶，其具有串联的不相同的催化结构域，缺少SH2或SH3结构域，并且在NK细胞和刺激或转化的T细胞中表达，但不在休息T 细胞。 蛋白质本身和对该蛋白质的抗体也被提出。 此外，鉴定用于调节免疫系统的治疗剂的方法利用上述。

公开(公告)号：US5296353A

公开(公告)日：1994-03-22

申请号：US863262

申请日：1992-04-06

申请人： Augusto C. Ochoa ,  Hiromoto Mizoguchi ,  John J. O'Shea ,  Dan L. Longo ,  Cynthia M. Loeffler

发明人： Augusto C. Ochoa ,  Hiromoto Mizoguchi ,  John J. O'Shea ,  Dan L. Longo ,  Cynthia M. Loeffler

IPC分类号： A61K38/00 ,  A61K38/20 ,  A61K39/00 ,  C07K14/47 ,  C07K16/18 ,  G01N33/573 ,  G01N33/574

CPC分类号： C07K16/18 ,  A61K38/2013 ,  C07K14/4703 ,  A61K39/00

摘要： A method of determining the level of immunosuppression in a mammal involves determining the level of expression of at least one selected TCR subunit protein, or protein in the T lymphocyte signal transduction pathway, and comparing the level to that found in healthy individuals. The method is useful to identify patients having T lymphocytes capable of activation for autologous adoptive immunotherapy and for identifying agents which cause or reverse immunosuppression.

摘要翻译： 确定哺乳动物免疫抑制水平的方法包括确定T淋巴细胞信号转导途径中至少一个选择的TCR亚基蛋白或蛋白质的表达水平，并将其水平与健康个体中的水平进行比较。 该方法可用于鉴定具有能够激活自体过继免疫治疗的T淋巴细胞的患者和用于鉴定导致或逆转免疫抑制的药物。

公开(公告)号：US07070972B1

公开(公告)日：2006-07-04

申请号：US08373934

申请日：1995-01-13

申请人： John J. O'Shea ,  Warren J. Leonard ,  James A. Johnston ,  Sarah M. Russell ,  Daniel W. McVicar ,  Masaru Kawamura

发明人： John J. O'Shea ,  Warren J. Leonard ,  James A. Johnston ,  Sarah M. Russell ,  Daniel W. McVicar ,  Masaru Kawamura

IPC分类号： C12N9/12 ,  C12N9/10 ,  C07K14/435

CPC分类号： C12N9/1205 ,  A61K48/00 ,  C07K16/40

摘要： An isolated polynucleotide encodes JAK-3 protein. JAK-3 protein is a protein tyrosine kinase having a molecular weight of approximately 125 kDa which has tandem non-identical catalytic domains, lacks SH2 or SH3 domains, and is expressed in NK cells and stimulated or transformed T cells, but not in resting T cells. The protein itself and antibodies to this protein are also presented. Further, methods of identifying therapeutic agents for modulating the immune system make use of the foregoing.